AutismKB 2.0

Annotation Detail for BAIAP2


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Basic Information Top
Gene Symbol:BAIAP2 ( BAP2,FLAF3,IRSP53 )
Gene Full Name: BAI1-associated protein 2
Band: 17q25.3
Quick LinksEntrez ID:10458; OMIM: 605475; Uniprot ID:BAIP2_HUMAN; ENSEMBL ID: ENSG00000175866; HGNC ID: 947
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
No data
Pathway IDPathway Name
200113ErbB1 downstream signaling
200190RAC1 signaling pathway
200057CDC42 signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of BAIAP2 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BAIAP2 mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of BAIAP2 mRNAincreases expression 18191166
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of BAIAP2 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BAIAP2 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A affects the expression of BAIAP2 mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of BAIAP2 mRNAdecreases expression 17484886
D002330 Carmustine Carmustine results in decreased expression of BAIAP2 mRNAdecreases expression 15980968
D002117 Calcitriol Calcitriol results in decreased expression of BAIAP2 mRNAdecreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of BAIAP2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BAIAP2 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of BAIAP2 mRNAdecreases expression 18035473
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of BAIAP2 mRNAincreases expression 20713471
D010795 Phthalic Acids Phthalic Acids results in decreased expression of BAIAP2 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in increased expression of BAIAP2 mRNAincreases expression 18445702
C446685 systhane systhane results in decreased expression of BAIAP2 mRNAdecreases expression 16730040
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BAIAP2 mRNAaffects cotreatment|increases expression 17942748
C032910 triadimefon triadimefon results in decreased expression of BAIAP2 mRNAdecreases expression 16730040
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1620464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1614692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.836695378
MESH:D000236 Adenoma Methylcholanthrene 6.8310545420 6695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4411922910
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.3520106747
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001862 Bone Resorption bisphenol A 3.8411985600
MESH:D001932 Brain Neoplasms Carmustine 4.3716187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3420146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.3417123778
MESH:D001943 Breast Neoplasms Calcitriol 2.3411237771
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.3417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7716124888 15673190 16011737 3786805 16097048 15721981 18705752 16227642 16192424 15700767 16050911 10355542
MESH:D002277 Carcinoma Methylcholanthrene 8.2810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.2816835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9716705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9718788625
MESH:D002278 Carcinoma in Situ bisphenol A 4.9817123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6720419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.6711237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3516120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.186135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.1820889678
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.1816192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6916919318 17110522 17681005 15861022 16105132 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 7.6919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1315668235 8697196 16354765 12621046 15340226
MESH:D002972 Cleft Palate triadimefon 6.1316781842
MESH:D003110 Colonic Neoplasms arsenite 2.5815037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities triadimefon 2.8315834900 16875885
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0018551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.1418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.1410092053 17522070 2869522 15998439 15027814 16227642 7179309 6623471 19336974 4309450 11566570 10915739 6884620 7120509 15968718 3786805 9327722 19085960 3732212 21278145 7440962 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.0415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0412538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver arsenite 18.6318296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.6315959796 16045604 12795759 16239168 17595544 19224547 12631006 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.6315345470
MESH:D005234 Fatty Liver pirinixic acid 18.6320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9310962813 14633661
MESH:D005355 Fibrosis arsenite 14.7618296743
MESH:D005355 Fibrosis Carbon Tetrachloride 14.7618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.7620067830
MESH:D005909 Glioblastoma Carmustine 3.9116187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 20.6919772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly systhane 20.6917178688 17178689
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 20.6916120746 15340226 12621046
MESH:D006529 Hepatomegaly triadimefon 20.6917178689 17178688
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516354765 15340226 16959395 18606429 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0715338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Flavonoids 4.9617296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9612878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.2716393666
MESH:D007333 Insulin Resistance pirinixic acid 7.2716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2616580747
MESH:D007569 Jaw Abnormalities triadimefon 10.2615992940 15834900
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9616705839
MESH:D008103 Liver Cirrhosis arsenite 6.7918296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7917174718 11408273 21278145 16239168 11903743 16221502 17334410 17157831 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.3718210741 12649538 15673190 18317297 18277467 15650968 18472094 15052691 15730626 15893842 14716496 18054572 12546737 15370692 16015684 18166357 17823541 11481614 14748882 16638106 12632514 15925388 12898905 16097048 17557913 14512876 16136751 16116963 18472332 17565644 12666154 15057751 17869086 15931870 17481882 20821823 17805973 18006644 18412020 18705752 15338365 14620537 18395914 17698563 16248980 14724832 16011737 12389079 17976157 12445418 18395095 17944888 12958196 17922224 12632512 18481824 18156304 18205269 18279442 18187930 15876570 14716833 15818738 12586293 15362042 18376398 18339082 18429990 17708605 17721639 17640975 12609069 18418968 16192424 17525996 17631135 17900296 13678700 15959796 18251166 17766677 12445421 18420326 12667390 15123356 16033810 17714472 15996030 17761835 12741479 10355542 16027843 18263696
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3712878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.4616246199 16964402 15720792 17285989 15830285
MESH:D008107 Liver Diseases triadimefon 4.4619363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6714706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.897678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.8920195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.8919294768
MESH:D008113 Liver Neoplasms pirinixic acid 17.8920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.8916984957
MESH:D008113 Liver Neoplasms triadimefon 17.8919028983
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 23.232876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 23.2312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 23.23598648 1399818
MESH:D008114 Liver Neoplasms, Experimental systhane 23.2317178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 23.2312151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 23.2317178689
MESH:D008175 Lung Neoplasms arsenite 4.8616809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8620064080 20464547 18816296 20135361 20869020 6695378 18569708 18520028 17053015
MESH:D008175 Lung Neoplasms Methylcholanthrene 4.867750092 6695378 21163286 10545420 16337739 20512841 16271038 11893704 9230183 17909032 15390079 20970405 1399818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8619555203 11884234
MESH:D008545 Melanoma Carmustine 2.8612393984
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.857678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7911141357
MESH:D009369 Neoplasms pirinixic acid 4.7917405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.4015738583
MESH:D009421 Nervous System Malformations bisphenol A 9.5316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5314600291
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4116049721
MESH:D010049 Ovarian Diseases bisphenol A 4.9811985600
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.4810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4811399792 11896295 11118676 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.7715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6117292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6116740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6116289102 18247401 15754350 16644109 12479363
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.7810548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5218551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4419755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019966 Substance-Related Disorders bisphenol A 3.9716045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms triadimefon 4.0717178689
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.9416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3110091137
MESH:D014591 Uterine Diseases bisphenol A 5.0114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04810 Regulation of actin cytoskeleton
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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