Annotation Detail for ZNHIT1
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of ZNHIT1 mRNA | affects expression | 21346803
|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of ZNHIT1 mRNA | affects expression | 17562736
|
| D020122 |
tert-Butylhydroperoxide |
tert-Butylhydroperoxide results in decreased expression of ZNHIT1 mRNA | decreases expression | 15336504
|
| D020122 |
tert-Butylhydroperoxide |
tert-Butylhydroperoxide results in increased expression of ZNHIT1 mRNA | increases expression | 15003993
|
| D014303 |
Trinitrotoluene |
Trinitrotoluene affects the expression of ZNHIT1 mRNA | affects expression | 21346803
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Trinitrotoluene |
4.82 | 7525203 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.57 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
2.96 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
2.96 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
8.21 | 10977129 |
| MESH:D002386 |
Cataract |
|
Trinitrotoluene |
8.21 | 15817613 14694615 |
| MESH:D000013 |
Congenital Abnormalities |
|
Trinitrotoluene |
4.77 | 15095906 |
| MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
13.17 | 18551238 |
| MESH:D003490 |
Cyanosis |
|
Trinitrotoluene |
13.17 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
6.85 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
6.85 | 16177239 11739529 12958197 12153990 16081117 16227642 16109766 12540782 15968718 12594235 15619225 16393943 12392966 11834606 10774834 11461765 19085960 19416960 11421492 12705907 17522070 16781746 19739265 11743745 18071297 14986274 11529661 19420014 16485898 19923254 2444490 19370779 17562736 17906064 10915739 14550746 11287661 14725611 10663392 19164858 18713872 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Trinitrotoluene |
6.85 | 21346803 18551238 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.82 | 19426721 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.40 | 16983495 |
| MESH:D006529 |
Hepatomegaly |
|
Trinitrotoluene |
4.79 | 15817613 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.02 | 16870215 |
| MESH:D007248 |
Infertility, Male |
|
Trinitrotoluene |
3.92 | 12150543 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.40 | 12587719 15629191 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
3.32 | 16705839 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.70 | 12969438 16610002 19784758 12587719 16611625 19014921 19460945 11587558 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.63 | 17185352 16871587 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.13 | 19513568 |
| MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
12.88 | 18551238 |
| MESH:D009336 |
Necrosis |
|
Trinitrotoluene |
12.88 | 18551238 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.21 | 18514411 |
| MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
10.56 | 12819281 16049721 |
| MESH:D009784 |
Occupational Diseases |
|
Trinitrotoluene |
10.56 | 12819281 17852074 14694615 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.73 | 16870215 |
| MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
7.07 | 18551238 |
| MESH:D012640 |
Seizures |
|
Trinitrotoluene |
7.07 | 18551238 |
| MESH:D012878 |
Skin Neoplasms |
|
tert-Butylhydroperoxide |
2.84 | 8532709 |
| MESH:D013163 |
Splenomegaly |
|
Trinitrotoluene |
5.76 | 15817613 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
2.41 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
4.95 | 10091137 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.44 | 10982225 |
Related Pathway Information