AutismKB 2.0

Annotation Detail for ATP5H


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Basic Information Top
Gene Symbol:ATP5H ( ATPQ )
Gene Full Name: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
Band: 17q25.1
Quick LinksEntrez ID:10476; OMIM: NA; Uniprot ID:ATP5H_HUMAN; ENSEMBL ID: ENSG00000167863; HGNC ID: 845
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of ATP5H mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ATP5H mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATP5H mRNAaffects expression 16483693
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of ATP5H mRNAaffects cotreatment|increases expression 18313992
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in increased expression of ATP5H proteinincreases expression 16400681
D004317 Doxorubicin Doxorubicin results in decreased expression of ATP5H proteindecreases expression 16144979
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ATP5H mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP5H mRNAaffects cotreatment|increases expression 17942748
D007657 Ketone Bodies Ketone Bodies results in increased expression of ATP5H mRNAincreases expression 15469884
C027869 lingzhi lingzhi results in decreased expression of ATP5H proteindecreases expression 18422750
D012643 Selenium Selenium results in decreased expression of ATP5H mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of ATP5H mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP5H mRNAaffects cotreatment|increases expression 17942748
D014315 Triterpenes Triterpenes results in decreased expression of ATP5H proteindecreases expression 18422750
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of ATP5H mRNAaffects cotreatment|increases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 8.996734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9911752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.909612607
MESH:D000230 Adenocarcinoma Doxorubicin 4.4317418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000419 Albuminuria Doxorubicin 4.6121441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8014601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.8617150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.1119526202 15634643 18695136 15692762 15136595 16595493 16264153 15993339 15994142 15567936 17369602 17426702 18628466 16935488 16096432 15939500 17983394 16322301 15668708 16826403 11325840 16115903 18382427 18234424
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1120435547
MESH:D002252 Carbon Tetrachloride Poisoning lingzhi 5.8915673190
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9116051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.613581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.613084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.6116234567 17876044 18059187 16023760
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.637296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.6316201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.656189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.5617974986 15505089 17382496 16109756 15811867 16952015 17007740 16651473 17924179 15792986 16612575 17928571 17329180 16269455 16455267 16731534 16364871 16278810 17308081 18627295 15476868 17351982 16242529 17519947 17131338
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9616243910 17334414
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.797505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.999022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9917110522 11677210 15861022 17681005 17333356 16105132 16919318
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.128697196 12621046 16354765 15668235 15340226
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.878970840 18759878 11298694 12868966 11906362 2524372 14531868 8156756
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 4.0716882537
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.486482804 1440618 18692083 16192314 8291058 7440962 9653073 6679447 18648102 9328219 11289319 18289764 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.4816485898 19085960 19370779 14986274 15619225 10774834 17562736 12392966 2444490 16081117 19923254 11834606 16393943 15968718 18713872 16227642 12594235 19420014 11743745 16109766 19164858 16177239 11739529 16781746 14725611 10915739 18071297 17906064 11461765 12540782 11529661 19416960 14550746 12958197 19739265 12153990 11421492 11287661 12705907 17522070 10663392
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 15.4817416283
MESH:D056486 Drug-Induced Liver Injury Selenium 15.4815131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 15.4815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.4820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Doxorubicin 20.0118602426
MESH:D004362 Drug Toxicity Lamivudine 20.0115040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 20.0111462148
MESH:D004362 Drug Toxicity Zidovudine 20.0115040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.4817359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2518037988
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1515345470
MESH:D005234 Fatty Liver Zidovudine 8.1518299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.6719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005909 Glioblastoma Doxorubicin 3.3817150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5615692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3610048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.5216879835 17875725 16244371 16495754 16144979 18006777 17888722 14766674 16707910 16244372 18674790 16330681 12587719
MESH:D006333 Heart Failure Doxorubicin 7.3517481944
MESH:D006333 Heart Failure Selenium 7.3517162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9515692506
MESH:D006402 Hematologic Diseases Zidovudine 4.7712579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006509 Hepatitis B Lamivudine 5.1517703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.1516476009 15631357 15274664 12044531 15309715
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9612621046 15340226 16120746
MESH:D015658 HIV Infections Lamivudine 7.1520032539 11141242 17530837 9296927
MESH:D015658 HIV Infections Zidovudine 7.1511141242 17358032 11363243 11698656 20032539
MESH:D006689 Hodgkin Disease Doxorubicin 3.4518501091 17606976 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 15340226 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812878042 12200463
MESH:D007251 Influenza, Human Selenium 4.2916624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3114714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 6.1616775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.1716707910
MESH:D007676 Kidney Failure, Chronic Selenium 10.1716518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.816582329
MESH:D007680 Kidney Neoplasms Zidovudine 7.8112579204
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2516085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.4720370541
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.239327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.8016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental lingzhi 3.8015673190
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.8012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6419460945 11587558 19014921 12587719 19784758 16610002 12969438 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 4.9111940454
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.9116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.036587162 3712494 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.0317085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0312151625
MESH:D008175 Lung Neoplasms Doxorubicin 3.556189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5519555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 3.5518800350
MESH:D008223 Lymphoma Doxorubicin 3.5016098063
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1214737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.3115458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3115318939
MESH:D008545 Melanoma Doxorubicin 2.2916827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Doxorubicin 6.3517638057
MESH:D008654 Mesothelioma Selenium 6.3515107826
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.9317358032
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5515792986
MESH:D052016 Mucositis Doxorubicin 4.8717415656
MESH:D009203 Myocardial Infarction Doxorubicin 2.9715857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.913581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.9118259882
MESH:D009401 Nephrosis Doxorubicin 4.8416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.0515640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D009447 Neuroblastoma Doxorubicin 3.2915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.476482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D012516 Osteosarcoma Doxorubicin 4.1615930896
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2517983394
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4215897917 16729912 16868541 16888761 15749863 18437689
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.4218760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D051437 Renal Insufficiency Doxorubicin 4.2917922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012206 Rhabdomyolysis Lamivudine 5.629296927
MESH:D012509 Sarcoma Doxorubicin 4.0416767912 18313854 17203757 17710206 15625365 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3116326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8717846226
MESH:D012878 Skin Neoplasms Doxorubicin 5.7715692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7716192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6415625365 16767912 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013276 Stomach Ulcer lingzhi 5.0612467913
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.406582329 1399818 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.4017909728 16010429
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.258074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.2517653716
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014625 Vaginal Neoplasms Zidovudine 4.8312579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5915869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2917638931 17334414 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25135
    • No data
    No data
    Releated drug ID Related drug Name
    PA165291922doxorubicinol
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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