AutismKB 2.0

Annotation Detail for UBE2E3


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Basic Information Top
Gene Symbol:UBE2E3 ( UBCH9,UbcM2 )
Gene Full Name: ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
Band: 2q31.3
Quick LinksEntrez ID:10477; OMIM: 604151; Uniprot ID:UB2E3_HUMAN; ENSEMBL ID: ENSG00000170035; HGNC ID: 12479
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa04120Ubiquitin mediated proteolysis
No data
No data
Pathway IDPathway Name
P00060Ubiquitin proteasome pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C459604 candoxin candoxin results in increased expression of UBE2E3 mRNAincreases expression 16309724
C051890 irinotecan irinotecan analog results in decreased expression of UBE2E3 mRNAdecreases expression 18927307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D003110 Colonic Neoplasms irinotecan 2.6517287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3717454858 17159606 15273666 18259882 18509181 16391804 16303861
MESH:D052016 Mucositis irinotecan 5.8917159606
MESH:D009362 Neoplasm Metastasis irinotecan 3.3218259882
MESH:D009447 Neuroblastoma irinotecan 3.698761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.628761367
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37129
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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