AutismKB 2.0

Annotation Detail for SLC9A6


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC9A6 ( KIAA0267,MRSA,NHE6 )
Gene Full Name: solute carrier family 9 (sodium/hydrogen exchanger), member 6
Band: Xq26.3
Quick LinksEntrez ID:10479; OMIM: 300231; Uniprot ID:SL9A6_HUMAN; ENSEMBL ID: ENSG00000198689; HGNC ID: 11079
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500336Sodium/Proton exchangers
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1789Movement disorder
No data
No data
Desease Name
Mental retardation, X-linked syndromic, Christianson type
Mental retardation, X-linked, South African type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SLC9A6 mRNAaffects expression 21346803
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC9A6 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7916705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.676135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.6712371664
MESH:D002779 Cholestasis Cyclosporine 3.2819486331
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.7818551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0718551238 21346803
MESH:D005234 Fatty Liver Cyclosporine 3.4019224547
MESH:D005355 Fibrosis Cyclosporine 3.9012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 5.118708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.3115720958
MESH:D006973 Hypertension Cyclosporine 2.2410903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.5115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.588314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.7516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.7512371664
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.297678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.822876784 6135515 2876786
OMIM:300243 MENTAL RETARDATION, X-LINKED, SYNDROMIC, CHRISTIANSON TYPE marker/mechanism
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.8616801185
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.7518551238 7678174
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.5117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7519348381 18481113
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.9416049721
MESH:D011230 Precancerous Conditions Cyclosporine 3.6912371664
MESH:D011565 Psoriasis Cyclosporine 2.3516882103
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8518551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4316049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.2010091137
MESH:D014605 Uveitis Cyclosporine 5.051336536
MESH:D014985 Xerophthalmia Cyclosporine 5.5117120751
Pathway ID Pathway Name
KEGG:04260 Cardiac muscle contraction
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35935
    • No data
    Releated disease ID Related disease Name
    PA446460Angelman Syndrome
    PA444929Mental Retardation
    PA152238066Mental Retardation, X-Linked
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved