AutismKB 2.0

Annotation Detail for SEC23A


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Basic Information Top
Gene Symbol:SEC23A ( CLSD,MGC26267 )
Gene Full Name: Sec23 homolog A (S. cerevisiae)
Band: 14q21.1
Quick LinksEntrez ID:10484; OMIM: 610511; Uniprot ID:SC23A_HUMAN; ENSEMBL ID: ENSG00000100934; HGNC ID: 10701
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
Pathway IDPathway Name
Membrane Trafficking
No data
No data
Pathway IDPathway Name
500009COPII (Coat Protein 2) Mediated Vesicle Transport
Related Diseases/Disorders Top
No data
No data
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No data
Desease Name
Craniolenticulosutural dysplasia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in increased expression of SEC23A mRNAincreases expression 15302862
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SEC23A mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen results in decreased expression of SEC23A mRNAdecreases expression 11793227
D002110 Caffeine Caffeine results in decreased expression of SEC23A mRNAdecreases expression 11793227
D005472 Fluorouracil SEC23A protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D007657 Ketone Bodies Ketone Bodies results in decreased expression of SEC23A mRNAdecreases expression 16807920
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to SEC23A protein]affects binding|increases reaction 17220478
D013853 Thioacetamide Thioacetamide results in decreased expression of SEC23A mRNAdecreases expression 11793227
D014212 Tretinoin Tretinoin results in increased expression of SEC23A mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.4717638652
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D000740 Anemia Fluorouracil 3.9017963324 16511603 15504547
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders Thioacetamide 10.0519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.0516206674 16197459
MESH:D001943 Breast Neoplasms Fluorouracil 2.2515136595 16595493 18357371 18608205 16110121 19217205 16557594
MESH:D001943 Breast Neoplasms Tretinoin 2.2516166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 3.7317121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.183084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.1817045692 16799960 16332177 17971768 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 9.1817997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.181917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.9018986760 16757204 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9016096774 16051514
MESH:D002386 Cataract Acetaminophen 7.6010977129
MESH:D002386 Cataract Tretinoin 7.6017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.4718291259
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617016597 16510598 17287894 17725105 17172411 15001691 17018589 18772588 17169374 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017094418 18802399 14970324 17695437 17255274 15148649 18288408 17401013 16391804 20501625 17594712 16282729 17454858 18448328 16331619 16524972 17016601 16303861 18509181 18949393 15289873 18383874
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8317551590 9142499 10589399 9125849 16925845 9664655 14991402 9211117 8800419 9224671
OMIM:607812 CRANIOLENTICULOSUTURAL DYSPLASIA marker/mechanism 17981132
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5811529661 11421492 12705907 14986274 18713872 17522070 14550746 17562736 19923254 19416960 15619225 16227642 10663392 11834606 11743745 15968718 12153990 11461765 12540782 18071297 10915739 16393943 17906064 16485898 19420014 19085960 2444490 16109766 11287661 16781746 11739529 14725611 12594235 12958197 19370779 16081117 19739265 16177239 19164858 12392966 10774834
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 6.5812963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2316569247
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4915173087 17638652 16337965 16481741 16785472
MESH:D005124 Eye Abnormalities Tretinoin 3.7316938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 6.0416456712
MESH:D005355 Fibrosis Tretinoin 3.7717994277
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.2415102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9914991402 9664655
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.7815929193 18665440 17276928
MESH:D006505 Hepatitis Caffeine 10.8011394713
MESH:D006505 Hepatitis Thioacetamide 10.8016456712
MESH:D006930 Hyperalgesia Acetaminophen 8.1816870215
MESH:D006930 Hyperalgesia Tretinoin 8.1816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1115992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0616705839
MESH:D007680 Kidney Neoplasms Fluorouracil 8.0616985049
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2819035177 16766008 17712046 17506722 19075265 17368321 17217047 17649720 17361223 19225113 16331271 12679006 17107899 17301526 15748426 16788101 16823087 16935935 17294898 19029980 19642359 17339181 16140955 16891316 9834237
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.7716248980 17050028 15465738 15288473 16343077 12085344 15158331 18395095 18458672 11172339 15362042 12891558 15288472 16098781 17355460 15078482 12175628 18263696 18031379 18032466 17292413 12679928 16489207 11682029 15716488 12557150 18380797 15334695 15095483 10677585 18295389 18416461 17629604 16511523 18606216 15075984 17127702 11481614 16097051 16126171 15474484 18615449 15316131 12531686 14739098
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.7716248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 4.2816610002 19014921 12587719 19460945 16611625 12969438 11587558 19784758
MESH:D008107 Liver Diseases Thioacetamide 4.2816337175 15158337 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 10.2916871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 10.2912479984 15313186 17276928 15633222
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.877678174
MESH:D008113 Liver Neoplasms Fluorouracil 4.8717045692 15113037 16603448 18383874
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.666135515 2876784 2876786
MESH:D008175 Lung Neoplasms Fluorouracil 2.0015246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7918986760 16757204
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.157678174 18551238
MESH:D009369 Neoplasms Fluorouracil 5.4618600527 18239605 16928823
MESH:D009369 Neoplasms Tretinoin 5.4616946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.029125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Acetaminophen 7.1616870215
MESH:D010146 Pain Tretinoin 7.1616870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5516500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5515976015
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3819082440 18626508
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1916160472 18286688 18722050 15538739
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216116481 16283617
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D012878 Skin Neoplasms Tretinoin 2.6916467112
MESH:D012893 Sleep Disorders Caffeine 5.6019395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 5.4217225163
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5519015929 19084572 16951190 17172411 18396642 18567086 16424979 15786421 17522103 17498489
MESH:D013274 Stomach Neoplasms Tretinoin 2.5517261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1816026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 10.4816280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.4816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3516049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.1116803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.1116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
Pathway ID Pathway Name
REACT:11123 Membrane Trafficking
REACT:17015 Metabolism of proteins
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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