AutismKB 2.0

Annotation Detail for CREB3


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Basic Information Top
Gene Symbol:CREB3 ( LUMAN,LZIP,MGC15333,MGC19782 )
Gene Full Name: cAMP responsive element binding protein 3
Band: 9p13.3
Quick LinksEntrez ID:10488; OMIM: 606443; Uniprot ID:CREB3_HUMAN; ENSEMBL ID: ENSG00000107175; HGNC ID: 2347
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04962Vasopressin-regulated water reabsorption
hsa05016Huntington's disease
hsa05215Prostate cancer
No data
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00055Transcription regulation by bZIP transcription factor
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CREB3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CREB3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CREB3 mRNAaffects expression 17562736
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of CREB3 mRNAincreases expression 16934159
D003474 Curcumin Curcumin results in increased expression of CREB3 mRNAincreases expression 18299980
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of CREB3 mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in increased expression of CREB3 mRNAincreases expression 20106945
D008727 Methotrexate CREB3 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D012643 Selenium Selenium results in increased expression of CREB3 mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of CREB3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.4812039119
MESH:D019973 Alcohol-Related Disorders Curcumin 5.3517887948
MESH:D000544 Alzheimer Disease Curcumin 2.6515590663
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001172 Arthritis, Rheumatoid Curcumin 5.1616807698
MESH:D001172 Arthritis, Rheumatoid Methotrexate 5.1617286800
MESH:D050197 Atherosclerosis Curcumin 3.4118704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Curcumin 4.7119761891
MESH:D002545 Brain Ischemia Curcumin 4.5716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1017596214
MESH:D001943 Breast Neoplasms Curcumin 2.6516243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Methotrexate 2.6516978400
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D002277 Carcinoma Curcumin 3.9718593918
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.643084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0318414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8018462866
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D003092 Colitis Curcumin 10.4016804969 18200517 16782535
MESH:D003092 Colitis Selenium 10.4017936198
MESH:D003103 Coloboma Curcumin 4.7218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5319359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.1118497527
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.0412039119 9562676
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.0419769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.4019747007
MESH:D003882 Dermatomyositis Methotrexate 5.3220191521
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7418403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.1618204486
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.8918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.8921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.8916485898 11834606 16081117 11461765 19085960 11529661 17562736 10663392 12594235 19739265 15968718 17906064 19370779 12705907 16109766 19416960 16393943 10915739 16177239 12958197 19164858 18071297 18713872 14986274 10774834 14725611 19923254 14550746 2444490 17522070 15619225 11421492 12540782 11287661 19420014 16227642 11739529 16781746 12153990 11743745 12392966
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 15.8917851650
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 15.8917654400
MESH:D056486 Drug-Induced Liver Injury Selenium 15.8915131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004381 Duodenal Ulcer Curcumin 4.2517351913
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D005234 Fatty Liver Curcumin 8.4819297423
MESH:D005234 Fatty Liver Cyclosporine 8.4819224547
MESH:D005355 Fibrosis Curcumin 9.5918705752
MESH:D005355 Fibrosis Cyclosporine 9.5912639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.9118462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Curcumin 3.5817596214
MESH:D006086 Graft vs Host Disease Methotrexate 5.3616518429
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7718829502 18462866
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.2617701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia Curcumin 4.2218704882
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007249 Inflammation Curcumin 2.9717151092 18403477 16956363
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2718596194 18200517
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007414 Intestinal Neoplasms Curcumin 4.3810783313
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 10.5515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.5518776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 10.5512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D007805 Language Development Disorders Methotrexate 5.299562676
MESH:D007889 Leiomyoma Curcumin 4.7618555241
MESH:D007938 Leukemia Curcumin 3.3218462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.3816106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.9616106398
MESH:D008103 Liver Cirrhosis Methotrexate 3.7914986274
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.7618705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.7616169303
MESH:D008107 Liver Diseases Acetaminophen 4.2216610002 19460945 12587719 19014921 11587558 12969438 16611625 19784758
MESH:D008107 Liver Diseases Curcumin 4.2216956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.217678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.646135515 2876784 2876786
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.2918516814
MESH:D008175 Lung Neoplasms Curcumin 2.7318462866 19359593 16243823
MESH:D008175 Lung Neoplasms Vitamin E 2.7311062179
MESH:D008223 Lymphoma Curcumin 8.3718462866
MESH:D008223 Lymphoma Methotrexate 8.3717352296
MESH:D016399 Lymphoma, T-Cell Curcumin 4.9116173963
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008545 Melanoma Curcumin 2.4317885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008569 Memory Disorders Curcumin 4.3517263510
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D052016 Mucositis Methotrexate 5.5217488658
MESH:D009101 Multiple Myeloma Curcumin 3.6319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.1617962980
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 4.5718495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.8012497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009423 Nervous System Neoplasms Curcumin 5.9018462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity Curcumin 2.7819297423
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D010024 Osteoporosis Curcumin 3.5718719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8618462866 19020741
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Curcumin 2.9919401701 17440100 19196508
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011471 Prostatic Neoplasms Curcumin 3.4115129424 18769126 11398177 18156803 10851300 12497104 18226269
MESH:D011471 Prostatic Neoplasms Vitamin E 3.4115084515
MESH:D011565 Psoriasis Cyclosporine 6.0816882103
MESH:D011565 Psoriasis Methotrexate 6.0817410198
MESH:D011656 Pulmonary Emphysema Curcumin 4.6919168576
MESH:D051437 Renal Insufficiency Methotrexate 4.9317352296
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2110666014 18379247
MESH:D012509 Sarcoma Curcumin 4.2818462866
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D018805 Sepsis Curcumin 4.2218389075
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013276 Stomach Ulcer Curcumin 3.6619188055 16631530
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013576 Syndactyly Methotrexate 5.239562676
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7116049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.7118593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.5018462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
KEGG:04916 Melanogenesis
KEGG:05215 Prostate cancer
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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