AutismKB 2.0

Annotation Detail for UNC13B


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Basic Information Top
Gene Symbol:UNC13B ( MGC133279,MGC133280,MUNC13,UNC13,Unc13h2,hmunc13 )
Gene Full Name: unc-13 homolog B (C. elegans)
Band: 9p13.3
Quick LinksEntrez ID:10497; OMIM: 605836; Uniprot ID:UN13B_HUMAN; ENSEMBL ID: ENSG00000198722; HGNC ID: 12566
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200160Effects of Botulinum toxin
Pathway IDPathway Name
P05734Synaptic vesicle trafficking
Pathway IDPathway Name
500150Glutamate Neurotransmitter Release Cycle
Related Diseases/Disorders Top
No data
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Desease Name
diabetes, type 1
IMMUNE
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of UNC13B mRNAincreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UNC13B mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of UNC13B mRNAdecreases expression 15963578
D010634 Phenobarbital Phenobarbital affects the expression of UNC13B mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of UNC13B mRNAaffects expression 19136022
C030984 pyrene pyrene results in decreased expression of UNC13B mRNAdecreases expression 15963578
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UNC13B mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.656195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6511752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.7517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.7516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.7516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416097048 16227642 16192424 15673190 18705752 15721981 16011737 15700767 3786805 10355542 16050911 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1518788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.151701930 17173139 20935162 6705139 20007298
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.208697196 15668235 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.953786805 19336974 10092053 19085960 17522070 16227642 6884620 9327722 6623471 16177239 7120509 3732212 2869522 4309450 11566570 15968718 21278145 7440962 10915739 15998439 15027814 7179309
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.6316239168 12795759 15959796 12631006 19224547 17595544 61145 16045604
MESH:D005234 Fatty Liver pirinixic acid 8.6320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 16.5816109766
MESH:D006529 Hepatomegaly pirinixic acid 16.5819176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.5812621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 15340226 8697196 16354765 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0911408273 16943688 17174718 16221502 11903743 21278145 17157831 16239168 17334410
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0921047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5318418968 17481882 10355542 17565644 16192424 14716496 12546737 17805973 12898905 18210741 18279442 16136751 15996030 18251166 17557913 18395095 18395914 15959796 18429990 15730626 18339082 18376398 12445421 18705752 15818738 16116963 18156304 12445418 17721639 15338365 17766677 15052691 12958196 18472094 17631135 16015684 13678700 14748882 12667390 18054572 12741479 16097048 15876570 16033810 18412020 16011737 15362042 18472332 17640975 17869086 18205269 14724832 12632512 17944888 12586293 17976157 16027843 18481824 15123356 17761835 18187930 18166357 17525996 15893842 18317297 12609069 12632514 11481614 14620537 18006644 15931870 14716833 17708605 17922224 20821823 16248980 15925388 15650968 18263696 17698563 18277467 12649538 15057751 12389079 15370692 14512876 17823541 12666154 15673190 16638106 17714472 17900296 18420326
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2916246199 15720792 16964402 17285989 15830285
MESH:D008107 Liver Diseases Phenobarbital 4.2919363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.4219294768
MESH:D008113 Liver Neoplasms Phenobarbital 11.4221047994 8742319 19812893 15975961 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 11.4216377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4216984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.7612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.761399818 18308698 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911222880 11896295 11399792 11118676
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures Phenobarbital 2.8711442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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