AutismKB 2.0

Annotation Detail for CARM1


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Basic Information Top
Gene Symbol:CARM1 ( PRMT4 )
Gene Full Name: coactivator-associated arginine methyltransferase 1
Band: 19p13.2
Quick LinksEntrez ID:10498; OMIM: 603934; Uniprot ID:CARM1_HUMAN; ENSEMBL ID: ENSG00000142453; HGNC ID: 23393
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200101Direct p53 effectors
200102Regulation of Androgen receptor activity
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1944Breast cancer
No data
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No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CARM1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of CARM1 mRNAaffects expression 21346803
D000242 Cyclic AMP CARM1 protein promotes the reaction [Cyclic AMP results in increased activity of ESR1 protein]increases activity|increases reaction 20360387
D000242 Cyclic AMP CARM1 protein promotes the reaction [Cyclic AMP results in increased expression of TFF1 mRNA]increases expression|increases reaction 20360387
D000242 Cyclic AMP Cyclic AMP promotes the reaction [CARM1 protein binds to ESR1 protein]affects binding|increases reaction 20360387
D000242 Cyclic AMP Cyclic AMP promotes the reaction [CARM1 protein binds to TFF1 promoter]affects binding|increases reaction 20360387
D000242 Cyclic AMP Cyclic AMP results in increased phosphorylation of CARM1 proteinincreases phosphorylation 20360387
D000242 Cyclic AMP [Cyclic AMP results in increased phosphorylation of CARM1 protein] promotes the reaction [CARM1 protein binds to ESR1 protein]affects binding|increases phosphorylation|increases reaction 20360387
D004317 Doxorubicin Doxorubicin promotes the reaction [CARM1 protein binds to ESR1 promoter]affects binding|increases reaction 19351845
D004317 Doxorubicin Doxorubicin promotes the reaction [TP53 protein binds to CARM1 protein]affects binding|increases reaction 19351845
D004958 Estradiol Estradiol promotes the reaction [CARM1 protein binds to TFF1 promoter]affects binding|increases reaction 20360387
D013629 Tamoxifen [CARM1 protein binds to ESR1 protein] which affects the susceptibility to Tamoxifenaffects binding|affects response to substance 20360387
D013629 Tamoxifen CARM1 protein promotes the reaction [Tamoxifen results in increased activity of ESR1 protein]increases activity|increases reaction 20360387
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.417525203
MESH:D000230 Adenocarcinoma Doxorubicin 4.7117418594
MESH:D000230 Adenocarcinoma Estradiol 4.7111473722
MESH:D000419 Albuminuria Doxorubicin 4.9321441931
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.2214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.1117150277
MESH:D001943 Breast Neoplasms Doxorubicin 1.9319526202 15692762 18695136 16935488 15136595 15567936 16264153 16322301 18628466 16595493 18234424 15634643 16115903 15939500 11325840 17426702 16096432 16826403 17369602 15994142 18382427 15993339 17983394 15668708
MESH:D001943 Breast Neoplasms Estradiol 1.9312948864 16675129 14630087 19861407 18497071 17261762 17289903 17018787
MESH:D001943 Breast Neoplasms Tamoxifen 1.9319410462 19189212 21138602 15565566 19059307 20135344 19288272 20859285 16873071 19115204 17242785 20390343 19244106 20544844 17049068 19189210 19487384 17893378 17440819 18629630 19103187 19011961 16273361 11161223 18997820 17261762 18855134 15668708 18351453 19155303 16202921 19084267 18821012 21152245 18984771 19200415 18425577 19221464 19289846 18815881 16818667 19066611 20065188 20005174 19142967
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D002276 Carcinoid Tumor Doxorubicin 5.3316051944
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9216705839
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.9216023760 18059187 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.9216924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.9216924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.281485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D009202 Cardiomyopathies Doxorubicin 3.7215792986 17974986 16952015 15811867 18627295 17382496 17351982 17007740 16269455 17924179 16278810 16612575 17928571 17519947 15505089 16455267 17329180 16364871 16731534 15476868 16651473 16242529 16109756 17308081 17131338
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0316243910 17334414
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7914694615
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9818566989
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1518802399 18259882
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4515095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003928 Diabetic Nephropathies Estradiol 9.8119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.8119279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.8321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.8321346803
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.8317416283
MESH:D004362 Drug Toxicity Doxorubicin 3.9018602426
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.9219031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 13.6117359293
MESH:D016889 Endometrial Neoplasms Estradiol 13.6118566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 13.6120544844 16202921 19155303 17893378
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6818037988
MESH:D005234 Fatty Liver Tamoxifen 3.4914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 13.0319069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 13.0319069698
MESH:D005909 Glioblastoma Doxorubicin 3.5417150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7315692506
MESH:D006331 Heart Diseases Doxorubicin 3.6918006777 17888722 16879835 16707910 16495754 18674790 16244372 16330681 17875725 12587719 14766674 16144979 16244371
MESH:D006333 Heart Failure Doxorubicin 3.5217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2315692506
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.6915147373 17606976 18501091
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D007249 Inflammation Tamoxifen 2.4919457130
MESH:D007333 Insulin Resistance Estradiol 3.1616393666 16627594
MESH:D007674 Kidney Diseases Doxorubicin 6.7515369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 6.7515618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4816707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.0116705839
MESH:D007680 Kidney Neoplasms Estradiol 14.0115610895
MESH:D007680 Kidney Neoplasms Tamoxifen 14.0118625569
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6816085563
MESH:D008064 Lipidoses Tamoxifen 3.3715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.7116439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.7114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.7118564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3116684651
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1917085340 16842330
MESH:D008175 Lung Neoplasms Doxorubicin 2.656189445 17418594
MESH:D008175 Lung Neoplasms Tamoxifen 2.6518625569
MESH:D008223 Lymphoma Doxorubicin 3.6816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9815621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 11.1215458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.1211807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.1216827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 14.4519453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.4519453300
MESH:D008545 Melanoma Doxorubicin 3.5516827129
MESH:D008545 Melanoma Tamoxifen 3.5519393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008654 Mesothelioma Doxorubicin 3.1617638057
MESH:D020326 Migraine without Aura Cyclic AMP 5.5411304026
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8315792986
MESH:D052016 Mucositis Doxorubicin 5.2517415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0515857846 19429709
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.2218259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.2219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009401 Nephrosis Doxorubicin 5.1916899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2915640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 4.0316427766 11399458
MESH:D009447 Neuroblastoma Doxorubicin 3.4015555623
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.1612819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 10.1614694615
MESH:D012516 Osteosarcoma Doxorubicin 4.3715930896
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6817638057
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.5316868541 15897917 16729912 16888761 15749863 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 2.5316740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5315067354
MESH:D051437 Renal Insufficiency Doxorubicin 4.6417922066
MESH:D012509 Sarcoma Doxorubicin 4.2915675481 17203757 17710206 16767912 15625365 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.2517846226
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D012878 Skin Neoplasms Doxorubicin 3.0815692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9815625365 16767912 17203757
MESH:D013088 Spermatocele Tamoxifen 4.8116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6116010429 17909728
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.9616049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.9617653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.9616712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.6417638931 16364871 17334414 17678736
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134959553
    • No data
    No data
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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