AutismKB 2.0

Annotation Detail for SEMA4D


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Basic Information Top
Gene Symbol:SEMA4D ( C9orf164,CD100,FLJ33485,FLJ34282,FLJ39737,FLJ46484,M-sema-G,MGC169138,MGC169141,SEMAJ,coll-4 )
Gene Full Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Band: 9q22.2
Quick LinksEntrez ID:10507; OMIM: 601866; Uniprot ID:SEM4D_HUMAN; ENSEMBL ID: ENSG00000187764; HGNC ID: 10732
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
No data
Pathway IDPathway Name
P00007Axon guidance mediated by semaphorins
Pathway IDPathway Name
500072Sema4D in semaphorin signaling
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SEMA4D mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of SEMA4D mRNAincreases expression 19774075
D001280 Atrazine Atrazine results in increased expression of SEMA4D mRNAincreases expression 18585445
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of SEMA4D mRNAdecreases expression 12057914
C020771 methylmercury hydroxide methylmercury hydroxide results in increased expression of SEMA4D mRNAincreases expression 20493249
D009151 Mustard Gas Mustard Gas results in increased expression of SEMA4D mRNAincreases expression 15674843
C006253 pirinixic acid pirinixic acid results in decreased expression of SEMA4D mRNAdecreases expression 17426115
C024746 tobacco tar tobacco tar results in increased expression of SEMA4D mRNAincreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.9211850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 9.9218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.5611874814
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0318057881 20041841 18218290
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D001281 Atrial Fibrillation Amiodarone 4.0818651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.9019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9019483382
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3510378619 17687719
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9615710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 4.1019559774
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0719370779 18071297 11421492 12958197 12153990 11834606 17522070 14550746 19923254 12705907 12392966 17906064 17562736 16177239 2444490 16227642 19164858 19416960 12594235 18713872 19420014 16081117 16485898 15968718 16393943 19085960 11529661 11739529 10663392 11743745 10774834 19739265 15619225 11287661 16109766 14986274 16781746 14725611 11461765 10915739 12540782
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.0715265979 18218290
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema Mustard Gas 7.6911402378 9260866 11428631 11428647
MESH:D004487 Edema pirinixic acid 7.6912083418
MESH:D019446 Endotoxemia Lipopolysaccharides 4.7317637181 15328337 15821434
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D005234 Fatty Liver Amiodarone 8.6214986274
MESH:D005234 Fatty Liver pirinixic acid 8.6219236843 20131406
MESH:D005334 Fever Lipopolysaccharides 4.2411852909 9205823
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6116366002
MESH:D006529 Hepatomegaly Amiodarone 9.6215265979
MESH:D006529 Hepatomegaly pirinixic acid 9.6219772884 16221962 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.128137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007037 Hypothyroidism Amiodarone 4.8217991464 18020914
MESH:D007248 Infertility, Male Atrazine 3.8612948887
MESH:D007249 Inflammation Lipopolysaccharides 5.8017255318 9205823 17237260 17963957 12878042
MESH:D007249 Inflammation Mustard Gas 5.809357497 16001271 8975870 11402378 17524151 11428647 11428631 9260866 11428620
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8917255318
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007970 Leukopenia Lipopolysaccharides 5.0315821434
MESH:D008064 Lipidoses Amiodarone 3.6815342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.5712878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5715474484
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 19784758 19014921 19460945 12969438 11587558 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8920007298 15890375 16377806
MESH:D008133 Long QT Syndrome Amiodarone 3.7617391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 8.1312587719
MESH:D008171 Lung Diseases Mustard Gas 8.1318161513 18702808
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D055370 Lung Injury Lipopolysaccharides 4.3121114838
MESH:D008175 Lung Neoplasms Mustard Gas 2.173148597 8781369
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Atrazine 3.611916698
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009181 Mycoses Amiodarone 5.2812754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009503 Neutropenia Mustard Gas 4.2316761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010300 Parkinson Disease Atrazine 3.3517218051
MESH:D011014 Pneumonia Lipopolysaccharides 4.8911605937 12224865
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D011658 Pulmonary Fibrosis Amiodarone 6.1111597910 12490602 12832656
MESH:D011658 Pulmonary Fibrosis Mustard Gas 6.1110334151 17266442 17720292 17620002 17894541
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8810835634
MESH:D012135 Respiratory Sounds Atrazine 4.8211874814
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D012871 Skin Diseases Mustard Gas 2.7612880345 15451306 16961503
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3915821434
MESH:D013959 Thyroid Diseases Amiodarone 5.1319731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.1718020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5317467628 11989578
MESH:D014581 Urticaria Acetaminophen 3.2410982225
Pathway ID Pathway Name
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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