AutismKB 2.0

Annotation Detail for SEMA4B


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Basic Information Top
Gene Symbol:SEMA4B ( KIAA1745,MGC131831,SEMAC,SemC )
Gene Full Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
Band: 15q25
Quick LinksEntrez ID:10509; OMIM: NA; Uniprot ID:; ENSEMBL ID: ENSG00000185033; HGNC ID: 10730
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C430898 AGN 194204 AGN 194204 results in increased expression of SEMA4B mRNAincreases expression 16339527
D016572 Cyclosporine Cyclosporine results in decreased expression of SEMA4B mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of SEMA4B mRNAincreases expression 16002434
D011374 Progesterone Progesterone affects the expression of SEMA4B mRNAaffects expression 17251523
D020849 Raloxifene Raloxifene results in decreased expression of SEMA4B mRNAdecreases expression 19429434
D013629 Tamoxifen Tamoxifen results in decreased expression of SEMA4B mRNAdecreases expression 19429434
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000419 Albuminuria Raloxifene 4.9817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.8617868700
MESH:D001930 Brain Injuries Progesterone 12.4015665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 12.4016580743
MESH:D001943 Breast Neoplasms Calcitriol 2.0411237771
MESH:D001943 Breast Neoplasms Progesterone 2.0415562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 2.0417261762 17242785 15775269 17595753 17049068 16912660 17952589 16837676 17440819 15758505 17893378 15572757
MESH:D001943 Breast Neoplasms Tamoxifen 2.0417893378 19103187 19189212 16273361 15565566 11161223 15668708 17440819 19011961 21152245 18855134 17261762 19084267 19066611 19288272 19200415 19221464 19142967 16202921 20005174 18351453 20065188 19115204 18997820 19189210 19244106 17049068 18821012 21138602 18984771 18815881 16818667 20544844 17242785 19487384 20390343 19410462 19155303 20859285 19059307 18629630 16873071 18425577 19289846 20135344
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6911237771
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.5317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.5317572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6515775269
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003072 Cognition Disorders Raloxifene 5.0415800139
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4517474826
MESH:D003928 Diabetic Nephropathies Raloxifene 10.0015920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 10.0019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.9117187935
MESH:D004487 Edema Raloxifene 3.6615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 25.4015138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 25.4017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 25.4015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 25.4019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2420544844 19155303 16202921 17893378
MESH:D004715 Endometriosis Progesterone 4.0716134523
MESH:D005234 Fatty Liver Cyclosporine 15.1319224547
MESH:D005234 Fatty Liver Raloxifene 15.1317473493
MESH:D005234 Fatty Liver Tamoxifen 15.1314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006331 Heart Diseases Raloxifene 3.7411110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006973 Hypertension Cyclosporine 5.6310903974
MESH:D006973 Hypertension Raloxifene 5.6315787275 17577099
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8215869954
MESH:D007249 Inflammation Progesterone 5.6515869954
MESH:D007249 Inflammation Tamoxifen 5.6519457130
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.508314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 8.2012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 8.2018625569
MESH:D007889 Leiomyoma Raloxifene 4.8516973256
MESH:D008064 Lipidoses Tamoxifen 3.3717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3116684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7217203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.7216827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6516497877
MESH:D009232 Myxoma Raloxifene 6.0816343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D010024 Osteoporosis Raloxifene 3.5719059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5817823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Progesterone 2.6017393432 16525653
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms AGN 194204 2.1216000583
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1212479363 18247401 16289102 15754350 16644109
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1215731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1215067354
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D011693 Purpura Raloxifene 6.0815770314
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9418045962
MESH:D013088 Spermatocele Tamoxifen 4.8116709447
MESH:D013119 Spinal Cord Injuries Progesterone 12.4615862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 12.4619457130
MESH:D020521 Stroke Raloxifene 4.0816837676
MESH:D013978 Tibial Fractures Raloxifene 5.7319048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5716712894 8653321 17572228
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D054556 Venous Thromboembolism Raloxifene 5.7316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0816343187
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:04360 Axon guidance
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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