AutismKB 2.0

Annotation Detail for MYBBP1A


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Basic Information Top
Gene Symbol:MYBBP1A ( FLJ37886,P160,PAP2 )
Gene Full Name: MYB binding protein (P160) 1a
Band: 17p13.2
Quick LinksEntrez ID:10514; OMIM: 604885; Uniprot ID:MBB1A_HUMAN; ENSEMBL ID: ENSG00000132382; HGNC ID: 7546
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MYBBP1A mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MYBBP1A mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MYBBP1A mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of MYBBP1A mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MYBBP1A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYBBP1A mRNAaffects expression 16483693
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MYBBP1A mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of MYBBP1A mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MYBBP1A mRNAaffects cotreatment|affects expression 17602206
C006253 pirinixic acid pirinixic acid results in increased expression of MYBBP1A mRNAincreases expression 18301758
D028321 Plant Preparations Plant Preparations affects the expression of MYBBP1A mRNAaffects expression 16046712
C402769 tipifarnib tipifarnib results in increased expression of MYBBP1A mRNAincreases expression 16403772
D014212 Tretinoin Tretinoin results in decreased expression of MYBBP1A mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.067525203
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.823712494
MESH:D000236 Adenoma Diethylnitrosamine 6.826695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.4916434500 19052882 17162532 19061943 18056438 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4916434500
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.2516197459 16206674
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0917474063
MESH:D001943 Breast Neoplasms Plant Preparations 2.0917398067
MESH:D001943 Breast Neoplasms Tretinoin 2.0916166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.5616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.5616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.563581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.563084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.5619107877 3084413 16540662 18210153 16698587 19052882 10737359 19171122 16830150 17138121 18788625 18393292 20935162 16569478 20101231 19539802 20007298 17978847 18665156 10672840 3581430 17173139 19383236 16288022 20432363 17428255 20524982 19919837 19519916 20514400 16878318 19701751 19394651 16935385 20512989 20214788 17162532 17761372 16328049 19208518 19335982 17055752 18494052 18506893 18971187 16779866 18978308 19822196 16807293 18785209 18691550 11831363 21159647 20727157 16681979 16502159 20084675 18056438 19418558
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.561917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 5.2217418620
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.2216051514 16096774
MESH:D002318 Cardiovascular Diseases Plant Preparations 4.4516862667
MESH:D016893 Carotid Stenosis Plant Preparations 6.2515158307
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.6414694615
MESH:D002386 Cataract Acetaminophen 12.6410977129
MESH:D002386 Cataract Tretinoin 12.6417460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.486135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.487505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.4812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.4817174075 21159647 2727394 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.7319486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.7319486331
MESH:D002779 Cholestasis pirinixic acid 13.7319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tretinoin 2.709407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.2315095906
MESH:D003324 Coronary Artery Disease Plant Preparations 4.0115158307
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8216925845 14991402 9224671 8800419 9142499 9125849 17551590 9664655 9211117 10589399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9011906362 12868966 14531868 8970840 2524372 11298694 8156756 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.5818289764 18648102 18692083 6482804 9653073 1440618 11289319 9328219 6679447 9022650 7440962 8291058 16192314
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.5821346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.5815619225 12540782 10663392 19739265 12594235 11529661 15968718 12958197 19164858 18071297 12392966 11461765 19420014 19416960 17562736 11834606 16485898 12705907 18713872 14725611 19085960 14986274 11739529 16781746 16177239 17906064 10774834 10915739 11743745 16109766 16393943 11287661 19923254 16081117 2444490 17522070 12153990 11421492 19370779 16227642 14550746
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.5819107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Plant Preparations 4.7311033412
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004489 Edema, Cardiac Tretinoin 4.6018230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1616569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 5.013581430
MESH:D004938 Esophageal Neoplasms Plant Preparations 5.0116510608
MESH:D005124 Eye Abnormalities Tretinoin 3.649664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 13.5319224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.5320387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 13.5319236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Cyclosporine 9.0412639820 12168785
MESH:D005355 Fibrosis Tretinoin 9.0417994277
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.939664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly pirinixic acid 3.1019772884 18467677 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 7.8416870215
MESH:D006930 Hyperalgesia Tretinoin 7.8416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007249 Inflammation Diethylnitrosamine 2.4118785209
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.159022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 3.9817551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.9410903974 18776723 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.3216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.3216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.326582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.3212371664
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7819285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2016140955 12679006 15748426 9834237 16331271 16891316 19029980 17649720 17301526 17294898 16766008 17339181 17368321 17506722 16935935 17361223 17217047 16788101 19642359 16823087 19035177 19075265 19225113 17107899 17712046
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8720032147 18522880 18665156 18407596 19638242
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.7015474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 3.7017724770
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.7016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.9712969438 16610002 19784758 12587719 19460945 11587558 19014921 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.967678174
MESH:D008113 Liver Neoplasms Clofibric Acid 10.9617602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.9621278145 20118626 19426721 19850985 19690152 19255062 12112319 2862719 15175105 19073162 18754104 19996281 20137499 21167192 12771043 20405173 19833225 19427195 20452335 19294768 18648771 19551842 19499222 19642983 19254457 18978307 18644402 16942905 9163691 20583210 19638242 10737359 19812893 20492335 18977376 21047994 19256749 2422723 20101389 19090486 15885732 20501860 21071580 20434301
MESH:D008113 Liver Neoplasms pirinixic acid 10.9620007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.136135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.13598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.133124819 18079962 19004024 18544905 17174075 18775883 21159647 18093689 18308698 19539802 18282651 19009564 18253720 18164116 19519916 16842330 19126423 9362446 17942915 2563599 16267830 17854601
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.0920512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms tipifarnib 3.0916885199
MESH:D008325 Mammary Neoplasms, Experimental tipifarnib 4.3816648579
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Plant Preparations 4.8417418620
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.7418551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.803581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.809029167 3581430
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009369 Neoplasms Tretinoin 5.0316594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Tretinoin 3.879125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.406679447
MESH:D009436 Neural Tube Defects Tretinoin 7.409142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 22.2512819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 22.2516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 22.254026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 22.2514694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Acetaminophen 6.8116870215
MESH:D010146 Pain Tretinoin 6.8116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3416540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3415976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D011230 Precancerous Conditions Cyclosporine 9.1912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.192563599
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0518551238
MESH:D012878 Skin Neoplasms Tretinoin 2.6416467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4418456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4417261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.326582329 6587162 7505956 3712494 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.327505956
MESH:D013964 Thyroid Neoplasms Tretinoin 12.3216026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.2316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.2316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.238074119
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 12.2311251952
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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