AutismKB 2.0

Annotation Detail for DDX17


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Basic Information Top
Gene Symbol:DDX17 ( DKFZp761H2016,P72,RH70 )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
Band: 22q13.1
Quick LinksEntrez ID:10521; OMIM: 608469; Uniprot ID:DDX17_HUMAN; ENSEMBL ID: ENSG00000100201; HGNC ID: 2740
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DDX17 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of DDX17 mRNAincreases expression 19774075
D001151 Arsenic DDX17 mRNA results in decreased susceptibility to Arsenicdecreases response to substance 17976673
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DDX17 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DDX17 mRNAdecreases expression 19150397
20018196
C459604 candoxin candoxin results in decreased expression of DDX17 mRNAdecreases expression 16309724
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of DDX17 mRNAdecreases expression 17490981
C006253 pirinixic acid pirinixic acid results in decreased expression of DDX17 mRNAdecreases expression 18445702
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of DDX17 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in decreased expression of DDX17 mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of DDX17 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DDX17 mRNAdecreases expression 15328365
C025643 vinclozolin vinclozolin affects the expression of DDX17 mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of DDX17 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of DDX17 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3517306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8820041841 18218290 18057881
MESH:D020261 Arsenic Poisoning Arsenic 2.8916251483 16835338 18414634 12569548
MESH:D050197 Atherosclerosis Arsenic 3.2912928151 19371607
MESH:D001281 Atrial Fibrillation Amiodarone 3.9618651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 15.8019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.8019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8920146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6315504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.053084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.0517306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.7917687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1518640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9215710769 19225199
MESH:D002318 Cardiovascular Diseases Arsenic 3.5019152805 17938729 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.3818022660 16973168
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2018974383
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7820889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis pirinixic acid 2.8819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 12621046 8697196 15340226 15668235
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1616109766 12540782 16781746 18713872 14725611 15619225 12958197 11743745 14986274 2444490 16177239 19370779 12705907 11739529 17906064 19923254 16227642 16393943 11834606 11529661 18071297 19739265 11461765 12594235 16081117 14550746 17522070 12153990 19416960 11287661 19085960 12392966 11421492 19420014 15968718 10663392 17562736 19164858 10774834 10915739 16485898
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.1618218290 15265979
MESH:D056486 Drug-Induced Liver Injury Selenium 9.1615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Amiodarone 8.0814986274
MESH:D005234 Fatty Liver pirinixic acid 8.0819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005534 Foot Diseases Arsenic 5.696392382
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.3420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.3411294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.3416080930
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Amiodarone 15.0515265979
MESH:D006529 Hepatomegaly pirinixic acid 15.0516221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.0516120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1818606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.959751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5317050553
MESH:D006973 Hypertension Arsenic 5.3216076760 9931084 11953799
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3218850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.6916093927
MESH:D007037 Hypothyroidism Amiodarone 4.6218020914 17991464
MESH:D007248 Infertility, Male vinclozolin 3.0916467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912200463 12878042
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007642 Keratosis Arsenic 5.1112749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 6.1115629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.1112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6017339181
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008064 Lipidoses Amiodarone 3.5715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4516169303
MESH:D008107 Liver Diseases Acetaminophen 4.1319460945 16610002 12969438 16611625 19014921 11587558 19784758 12587719
MESH:D008107 Liver Diseases Arsenic 4.1311134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 10.9216368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.9220195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 10.9220007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6411989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 7.7012587719
MESH:D008171 Lung Diseases Vitamin E 7.7016863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6118516814
MESH:D008175 Lung Neoplasms Arsenic 4.9217306315 17976673 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9220464547 20064080 18816296 6695378 18569708 20135361 17053015 18520028 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9211884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.9211062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009181 Mycoses Amiodarone 5.0412754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Arsenic 9.2215371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.2212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9511141357
MESH:D009369 Neoplasms pirinixic acid 4.9517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects Arsenic 3.5016620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.4617056641
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D010051 Ovarian Neoplasms Arsenic 2.7717306315
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2716093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1116905509 6392382 15371236
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8811399792 11896295 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.8818042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011471 Prostatic Neoplasms Arsenic 2.5816140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5817292933
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5815084515
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011507 Proteinuria Arsenic 4.0921343184
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8812490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2018724381
MESH:D012871 Skin Diseases Arsenic 5.1017548696 19834688 16759981 16353154 15952646 17050553 18709164 17938729 16702368 17453740 6392382
MESH:D012871 Skin Diseases Vitamin E 5.1018709164
MESH:D012878 Skin Neoplasms Arsenic 9.6517976673 15504454 17029826 17050553 19538983 16251483
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.6519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 3.4018087811
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D013610 Tachycardia Amiodarone 4.3811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2819225199
MESH:D013959 Thyroid Diseases Amiodarone 12.5119731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.5112697716
MESH:D013971 Thyrotoxicosis Amiodarone 4.9618020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.3111989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.2617306315 17976673 15987713 19322015 19429237 11144890 18640142
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2617053015
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014652 Vascular Diseases Arsenic 4.8517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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