AutismKB 2.0

Annotation Detail for DEAF1


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Basic Information Top
Gene Symbol:DEAF1 ( NUDR,SPN,ZMYND5 )
Gene Full Name: deformed epidermal autoregulatory factor 1 (Drosophila)
Band: 11p15.5
Quick LinksEntrez ID:10522; OMIM: 602635; Uniprot ID:DEAF1_HUMAN; ENSEMBL ID: ENSG00000177030; HGNC ID: 14677
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DEAF1 mRNAaffects expression 17562736
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DEAF1 mRNAaffects cotreatment|increases expression 20360939
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of DEAF1 mRNAaffects cotreatment|increases expression 19684285
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DEAF1 mRNAaffects cotreatment|increases expression 20360939
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of DEAF1 mRNAdecreases expression 12634122
C008493 methylselenic acid methylselenic acid results in decreased expression of DEAF1 mRNAdecreases expression 18548127
C029938 nickel sulfate nickel sulfate results in increased expression of DEAF1 mRNAincreases expression 16780908
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of DEAF1 mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DEAF1 mRNAincreases expression 19684285
D015032 Zinc Zinc binds to DEAF1 proteinaffects binding 16527309
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000169 Acrodermatitis Zinc 5.6917202136 17190629 16889938
MESH:D055371 Acute Lung Injury nickel sulfate 4.5312718980 19131640 16100012 11954676
MESH:D000236 Adenoma Diethylnitrosamine 2.9610737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0316434500 17162532 19061943 19052882 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0316835633
MESH:D000544 Alzheimer Disease Zinc 2.7916325427 16410023 16580781 17119284
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.1416916123
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001249 Asthma Zinc 3.0017085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001930 Brain Injuries Zinc 4.9517109824
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9316779866 19539802 11831363 18788625 18056438 18210153 18978308 17978847 18691550 19052882 16681979 17173139 16830150 17055752 20007298 19919837 17162532 16502159 20524982 20084675 20101231 20935162 19383236 10672840 19107877 19519916 20512989 16288022 17428255 19335982 19822196 16878318 16540662 17138121 16698587 18393292 21159647 19171122 18494052 19394651 20432363 18506893 10737359 19701751 20727157 17761372 16935385 20514400 20214788 18785209 18971187 16328049 19418558 16807293 18665156 3084413 16569478 3581430 19208518
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.9516543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Zinc 3.7916936243
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.6017174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 7.602727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 15340226 15668235 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7215322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Zinc 2.7219302082
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.9316780908 16823706 11298694
MESH:D003920 Diabetes Mellitus Zinc 4.3916479319
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4311529661 12392966 19739265 18713872 14550746 19370779 11461765 11743745 19416960 17562736 12540782 16485898 12153990 2444490 14986274 11739529 11287661 10774834 19085960 19923254 12958197 19164858 17906064 19420014 16781746 16109766 10915739 12594235 15968718 10663392 14725611 16081117 11421492 15619225 17522070 16393943 18071297 16227642 11834606 16177239 12705907
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms Zinc 2.9016543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3921071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005756 Gastritis Acetaminophen 12.2516983495
MESH:D005756 Gastritis Zinc 12.2517241300
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006130 Growth Disorders Zinc 4.0817217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006333 Heart Failure Zinc 3.7317162251
MESH:D006335 Heart Injuries Zinc 6.0917074742
MESH:D016481 Helicobacter Infections Zinc 4.7517241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.9517276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 5.2218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2212878042 12200463
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.7810783313
MESH:D007511 Ischemia Zinc 4.8916584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 10.8815629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 10.8815369732
MESH:D007674 Kidney Diseases Zinc 10.8816960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.6316518626
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1216766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318665156 19638242 18522880 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 4.0519460945 11587558 19784758 16610002 12969438 12587719 19014921 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.6319073162 10737359 19833225 12771043 20583210 19426721 19427195 19499222 19255062 19638242 15885732 20492335 9163691 21278145 19996281 19254457 16942905 21047994 20434301 19256749 21167192 18648771 19850985 20137499 18978307 12112319 20118626 19812893 20501860 19690152 21071580 20405173 2422723 20452335 19642983 20101389 19294768 18644402 2862719 18754104 15175105 18977376 19090486 19551842
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6316984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.179362446 3124819 19519916 19009564 2563599 18079962 18093689 19539802 18253720 16267830 18164116 17942915 19004024 18775883 16842330 18544905 17854601 19126423 21159647 17174075 18308698 18282651
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1712151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.316695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3111884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.4212773700
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008607 Mental Retardation marker/mechanism 21076407
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 6.1717671175
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.643581430 9029167
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011225 Pre-Eclampsia Zinc 4.3317114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.6716205645
MESH:D011471 Prostatic Neoplasms Zinc 3.6716606632 16517595 16700911 12429649
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration Zinc 4.2816584753
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.147505956
MESH:D014062 Tongue Neoplasms Zinc 4.5916543248
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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