AutismKB 2.0

Annotation Detail for CHERP


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Basic Information Top
Gene Symbol:CHERP ( DAN16,SCAF6,SRA1 )
Gene Full Name: calcium homeostasis endoplasmic reticulum protein
Band: 19p13.11
Quick LinksEntrez ID:10523; OMIM: NA; Uniprot ID:CHERP_HUMAN; ENSEMBL ID: ENSG00000085872; HGNC ID: 16930
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CHERP mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CHERP mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CHERP mRNAaffects expression 17562736
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CHERP mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CHERP mRNAaffects cotreatment|affects expression 17602206
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CHERP mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 15322242 11752688
MESH:D000236 Adenoma Diethylnitrosamine 3.0110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.6519061943 19052882 16434500 18056438 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.6516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.883084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8817428255 19539802 19383236 17978847 21159647 19171122 16807293 17138121 19822196 17055752 19418558 16328049 19107877 20514400 20084675 18393292 19394651 17173139 16681979 16288022 18056438 16878318 10737359 10672840 18494052 18788625 17761372 19701751 20512989 16502159 17162532 18506893 3581430 20727157 3084413 16569478 19052882 20214788 16779866 16698587 18971187 19208518 20935162 16540662 20101231 19919837 11831363 16935385 20007298 16830150 20524982 18978308 18691550 18210153 18665156 18785209 19335982 19519916 20432363
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.396135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.397505956 17174075 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.2919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.2916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 15340226 8697196 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4317107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.8518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.8521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.8512958197 10915739 16081117 16781746 18071297 11287661 16109766 10663392 10774834 17906064 17522070 12153990 11421492 19739265 16485898 14550746 19416960 19164858 14986274 12594235 15968718 19370779 14725611 11743745 11834606 11739529 12705907 19420014 12392966 18713872 19085960 12540782 16227642 19923254 16393943 2444490 16177239 11529661 11461765 15619225 17562736
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.8519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.8520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Diethylnitrosamine 3.5121071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5718606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 5.3818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3812878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2716705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9818665156 18407596 18522880 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 4.1212969438 16610002 19460945 16611625 19014921 19784758 12587719 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1217034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.557678174
MESH:D008113 Liver Neoplasms Clofibric Acid 11.5517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.5512112319 19073162 19690152 20501860 20137499 19427195 12771043 19812893 19638242 20492335 19294768 16942905 19499222 19850985 21278145 19551842 19426721 10737359 19254457 20405173 2862719 2422723 18977376 20452335 19642983 19833225 18648771 19256749 19255062 18978307 20583210 18644402 20101389 15885732 21071580 18754104 19996281 20434301 15175105 9163691 21167192 21047994 19090486 20118626
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.5516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.872876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.8718093689 19539802 19126423 16267830 17942915 19009564 18544905 18079962 18253720 18308698 3124819 9362446 17854601 18282651 18775883 19519916 18164116 16842330 2563599 19004024 17174075 21159647
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8712151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3320512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3319555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.9418551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.679029167 3581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.0918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 9.0920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511399792 11896295 11222880 11118676
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.227505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:03040 Spliceosome
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26459
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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