AutismKB 2.0

Annotation Detail for ATG7


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Basic Information Top
Gene Symbol:ATG7 ( APG7-LIKE,APG7L,DKFZp434N0735,GSA7 )
Gene Full Name: ATG7 autophagy related 7 homolog (S. cerevisiae)
Band: 3p25.3
Quick LinksEntrez ID:10533; OMIM: 608760; Uniprot ID:ATG7_HUMAN; ENSEMBL ID: ENSG00000197548; HGNC ID: 16935
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04140Regulation of autophagy
No data
No data
Pathway IDPathway Name
P00060Ubiquitin proteasome pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ATG7 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ATG7 mRNAaffects expression 21346803
C058317 arsenic disulfide arsenic disulfide results in decreased expression of ATG7 mRNAdecreases expression 12890387
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ATG7 mRNAdecreases expression 20106945
20064835
D004051 Diethylhexyl Phthalate ATG7 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ACAA1A protein]decreases reaction|increases expression 16332691
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ATG7 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ATG7 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATG7 mRNAaffects cotreatment|increases expression 17942748
D019311 Staurosporine ATG7 protein affects the susceptibility to Staurosporineaffects response to substance 16497721
D013629 Tamoxifen Tamoxifen affects the expression of ATG7 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATG7 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 16.157525203
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 16.156734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.1514514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3214692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 1.7917261762 18997820 19189210 18855134 21138602 19066611 19189212 18629630 17049068 16273361 15668708 11161223 15565566 19155303 19410462 19059307 20390343 18351453 19084267 19142967 19115204 17893378 19487384 16818667 20544844 16202921 19103187 18821012 19288272 19011961 19289846 20135344 18425577 19244106 20859285 19221464 17440819 18815881 20005174 20065188 18984771 17242785 19200415 21152245 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0616705839
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0616924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 16120746 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7414694615
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0217110522 16105132 17333356 16919318 11677210 15861022 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 12621046 8697196 16354765 15340226
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.8015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.8017141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 4.1316882537
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.5621346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Staurosporine 7.918273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.9111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1716202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3815345470
MESH:D005234 Fatty Liver Tamoxifen 8.3814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16959395 8697196 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9616705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.9618625569
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 5.0512421474
MESH:D008064 Lipidoses Tamoxifen 3.3017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.3121137059 20195826
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 11.3111940454
MESH:D008113 Liver Neoplasms Tamoxifen 11.3116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4520135361 18816296 6695378 18569708 20869020 18520028 20064080 20464547 17053015
MESH:D008175 Lung Neoplasms Tamoxifen 3.4518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4511884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7416827153 19196722 19196723 11731420 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7812819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.7814694615
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0817292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7610029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6917053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.6917572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:04140 Regulation of autophagy
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134983397
    • Releated gene ID Related gene Name
    PA356TPMT
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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