AutismKB 2.0

Annotation Detail for UBD


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Basic Information Top
Gene Symbol:UBD ( FAT10,GABBR1,UBD-3 )
Gene Full Name: ubiquitin D
Band: 6p22.1
Quick LinksEntrez ID:10537; OMIM: 606050; Uniprot ID:UBD_HUMAN; ENSEMBL ID: ENSG00000213886; HGNC ID: 18795
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1883Polycystic kidney
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D012436 S-Adenosylmethionine S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA]decreases reaction|increases expression 18098314
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of UBD proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UBD mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of UBD mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of UBD mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of UBD mRNAdecreases expression 20127859
C006780 bisphenol A bisphenol A results in increased expression of UBD mRNAincreases expression 18180321
C032036 bromobenzene bromobenzene results in decreased expression of UBD mRNAdecreases expression 15056800
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of UBD mRNAincreases expression 17720352
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of UBD mRNAincreases expression 15331540
D016572 Cyclosporine Cyclosporine results in increased expression of UBD mRNAincreases expression 20106945
D003997 Dicarbethoxydihydrocollidine Dicarbethoxydihydrocollidine results in increased expression of UBD mRNAincreases expression 18098314
D003997 Dicarbethoxydihydrocollidine S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA]decreases reaction|increases expression 18098314
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of UBD mRNAincreases expression 18506893
D004052 Diethylnitrosamine XRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of UBD mRNA]decreases reaction|increases expression 18506893
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of UBD mRNAaffects cotreatment|increases expression 18164116
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of UBD mRNAdecreases expression 17547211
D004958 Estradiol Estradiol results in increased expression of UBD mRNAincreases expression 20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of UBD mRNAaffects cotreatment|decreases expression 17404688
C533894 LG 100815 LG 100815 results in increased expression of UBD mRNAincreases expression 16951191
C029938 nickel sulfate nickel sulfate results in increased expression of UBD mRNAincreases expression 16780908
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of UBD mRNAincreases expression 17616710
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of UBD mRNAincreases expression 16951191
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of UBD mRNAincreases expression 16221955
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of UBD mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of UBD mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of UBD mRNAdecreases expression 17426115
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of UBD mRNAaffects cotreatment|decreases expression 17404688
C045950 propiconazole propiconazole results in increased expression of UBD mRNAincreases expression 19363144
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UBD mRNAincreases expression 20106945
D014212 Tretinoin Tretinoin results in increased expression of UBD mRNAincreases expression 16951191
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of UBD mRNAincreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.596195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5914514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D055371 Acute Lung Injury nickel sulfate 8.4916100012 12718980 19131640 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 8.4918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8320127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 6.8316033868
MESH:D000230 Adenocarcinoma Estradiol 6.8311473722
MESH:D000236 Adenoma Benzo(a)pyrene 15.036695378
MESH:D000236 Adenoma beta-Naphthoflavone 15.0319389873
MESH:D000236 Adenoma Diethylnitrosamine 15.0310737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 15.0319555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.1216434500 17162532 19052882 17620307 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.1217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.1216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.1216835633
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.3915014928
MESH:D001169 Arthritis, Experimental Tretinoin 2.9516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001321 Autistic Disorder S-Adenosylmethionine 3.6619056591 16917939
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.1719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.1712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.1716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001862 Bone Resorption bisphenol A 3.6711985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1317868700
MESH:D001930 Brain Injuries Progesterone 4.0515665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.6217474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 5.6217123778
MESH:D001943 Breast Neoplasms Cacodylic Acid 5.6217474063
MESH:D001943 Breast Neoplasms Cyclophosphamide 5.6217388661 15093573 15136595 18234424 17020986 11325840 16978400 18323546 12006526
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.6217474063
MESH:D001943 Breast Neoplasms Estradiol 5.6214630087 16675129 18497071 12948864 17261762 17289903 17018787 19861407
MESH:D001943 Breast Neoplasms Progesterone 5.6215562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6220435547
MESH:D001943 Breast Neoplasms Tretinoin 5.6216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Dimethylnitrosamine 7.8119555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 19363144
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.9312619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 10.9319701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.9320432363 17761372 18691550 3084413 18494052 21159647 10672840 18210153 20101231 19394651 18665156 20084675 19208518 11831363 19418558 20514400 17162532 17138121 17055752 20214788 10737359 16935385 19107877 16288022 16830150 20935162 18056438 18506893 20512989 19519916 16540662 17978847 16698587 19052882 18978308 20727157 19919837 16779866 16681979 18785209 18971187 16502159 19383236 16569478 18393292 16328049 19335982 16878318 19171122 18788625 19822196 16807293 20524982 20007298 19701751 17173139 19539802 3581430 17428255
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.9316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.9320935162 1701930 6705139 20007298 17173139
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.931917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7817123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.6816152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.4416201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.2220419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 7.2216033868
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.2216096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518850075 16120746 18670907
MESH:D002386 Cataract Tretinoin 2.9717460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.3321159647 7505956 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.3318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis Cyclosporine 7.2519486331
MESH:D002779 Cholestasis pirinixic acid 7.2519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4712621046 16354765 15340226 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003092 Colitis Tretinoin 9.0917035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.0916867261 17991707 18200517 11698051 17936198 18023891 16782535 16474422 16804969
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3717276891
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.389664655 9142499 10589399 9224671 9125849 16925845 14991402 9211117 17551590 8800419
MESH:D003556 Cystitis Cyclophosphamide 4.7716989017 18372110 18433785 16413132 11948286 15276878 17979934 10498854 18710439 18093676 18295254 16614059 12913760 12388444 18483878 16651033 15643279 12161096 10700343 17010015
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.4816780908 16823706 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9015331540 10990075 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1618772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2817187935
MESH:D056486 Drug-Induced Liver Injury bromobenzene 8.5310092053 12628495
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.5319107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 8.538172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004421 Dystonia Phenobarbital 3.811851702
MESH:D004487 Edema perfluorooctanoic acid 10.3717259670 12083418
MESH:D004487 Edema pirinixic acid 10.3712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.3711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.5817692515
MESH:D016889 Endometrial Neoplasms Estradiol 6.9611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.9616569247
MESH:D004715 Endometriosis Progesterone 8.3216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.3210568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 4.0111006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.903659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.663922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.376401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.813659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0616530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.0617016578
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.0615623463 16805852 15264214 15547733 16704527 15150132 15547721 16510608 15878914
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3216938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 11.9519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 11.9520387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 11.9520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005355 Fibrosis Cyclosporine 19.4712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.4720067830
MESH:D005355 Fibrosis Tretinoin 19.4717994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 19.4717994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Tretinoin 2.8717312396
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3011389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.8315172196 16376943 11014644
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.4620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.4614991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.0811918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3214986274
MESH:D006529 Hepatomegaly perfluorooctanoic acid 24.943609246
MESH:D006529 Hepatomegaly Phenobarbital 24.9416109766
MESH:D006529 Hepatomegaly pirinixic acid 24.9418467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly propiconazole 24.9417178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 24.9415340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.6117606976 16135485
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.838697196 15340226 16959395 18606429 16354765
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.5012083418
MESH:D006930 Hyperalgesia Tretinoin 7.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818670907 18850075
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1216076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1915869954
MESH:D007248 Infertility, Male Cyclophosphamide 3.4816517039 7193160
MESH:D007249 Inflammation Diethylnitrosamine 11.0918785209
MESH:D007249 Inflammation perfluorooctanoic acid 11.0912083418
MESH:D007249 Inflammation Progesterone 11.0915869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.0912200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.4918200517
MESH:D007333 Insulin Resistance bisphenol A 11.5316393666
MESH:D007333 Insulin Resistance Estradiol 11.5316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.5316306350
MESH:D007410 Intestinal Diseases Tretinoin 9.3017994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 9.3017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3017551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Cyclosporine 5.5418776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 5.5415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.7112371664
MESH:D007680 Kidney Neoplasms Estradiol 6.7115610895
MESH:D007938 Leukemia Cyclophosphamide 6.2410602166
MESH:D007938 Leukemia Tretinoin 6.2417143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4117008537 17802794 18172266 17658394 17296974 18587576
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.9310373061
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5119285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0417596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0217361223 12679006 17301526 16766008 16935935 19029980 17649720 16140955 16823087 9834237 17294898 16331271 16891316 17368321 19075265 15748426 16788101 17339181 19225113 17217047 19035177 19642359 17712046 17107899 17506722
MESH:D007970 Leukopenia Cyclophosphamide 4.7511830472 10052129
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.028812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.169224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2620032147 19638242 18665156 18407596 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2621047994
MESH:D008106 Liver Cirrhosis, Experimental Dicarbethoxydihydrocollidine 10.5216015684
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 10.5215571005 16603200 17198567 12918455 18095165 16570917 15081153 16544323 14643895 16270385 17348192 15298665 17432682 18567088 18672772 15942678 17666798 15504291 16627068 18210741 15864749 17719030 18364076 15138612 15577212 17196135 15383259 16042886 17201889 15723089 15492853 15733078 15763062 18237412 16009107 15366600 17036385 15339415 17724770 18637143 14726149 15099470 14709902 18371158 16169303 15067225 18239293 15086199 15369754 15793283 14568256 17203207 15744066 15161499 12925901 17881167 15798949 17534399 17465448 14659978 15479170 17640959 18629640 15842777 15591649
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.5214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.5215474484
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 10.5215983038
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.5212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.5218397230 16248980
MESH:D008107 Liver Diseases Diethylnitrosamine 6.3717034775
MESH:D008107 Liver Diseases Phenobarbital 6.3719363144
MESH:D008107 Liver Diseases propiconazole 6.3719363144
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.2217457977
MESH:D008113 Liver Neoplasms Aflatoxin B1 32.7815890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 32.7820195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 32.7819389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 32.7819812893 18978307 19690152 20101389 19638242 19850985 18644402 15885732 19294768 21167192 20137499 15175105 19427195 19090486 9163691 19642983 19073162 2422723 20583210 19551842 18977376 2862719 12771043 19255062 21047994 21071580 19426721 20118626 19833225 20434301 20492335 19254457 20452335 19996281 16942905 18648771 20405173 20501860 18754104 19256749 10737359 12112319 21278145 19499222
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 32.783113478 15890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 32.7818709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 32.788742319 19482888 19812893 15975961 19073162 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 32.7816377806 20007298 15890375
MESH:D008113 Liver Neoplasms propiconazole 32.7819028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 32.7816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 26.298603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 26.2918164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.292563599 19009564 21159647 18775883 17854601 17942915 18282651 19126423 19004024 16267830 16842330 18164116 18308698 18079962 9362446 18093689 19519916 18253720 17174075 19539802 3124819 18544905
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 26.296150874 15603536 1848544
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 26.291399818 6150874 18308698 2563599 17172636
MESH:D008114 Liver Neoplasms, Experimental propiconazole 26.2917178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.2912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.3114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.3118569708 20064080 6695378 18520028 20135361 20464547 18816296 20869020 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.3120512841 21163286 6695378 20970405
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 6.3119555203 16061637 11884234
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3111884234 19555203
MESH:D008223 Lymphoma Cyclophosphamide 3.6912854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.4016675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.0011911406
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.6217203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.6211408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Tretinoin 1.9216752155
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.5916388313
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.483581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 11.0211141357
MESH:D009369 Neoplasms Cyclophosphamide 11.0218854779
MESH:D009369 Neoplasms pirinixic acid 11.0217405874
MESH:D009369 Neoplasms Tretinoin 11.0216594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 21.7716427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 21.7716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.7714600291
MESH:D009421 Nervous System Malformations Tretinoin 21.779125849
MESH:D009436 Neural Tube Defects Tretinoin 2.929142499
MESH:D009447 Neuroblastoma Cyclophosphamide 3.538761367 15176712 16115947
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1720387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.6812837982 8761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009503 Neutropenia Cyclophosphamide 4.138291058
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.759802331
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009845 Oligospermia Cyclophosphamide 4.5016517039
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010049 Ovarian Diseases bisphenol A 4.7811985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.4919401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.4917393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 7.4916936753
MESH:D010146 Pain Cyclophosphamide 6.4812161096 18093676
MESH:D010146 Pain Tretinoin 6.4816870215
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 11.7311332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7316540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.7316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.7315976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.0117698068
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.2512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.252563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.252563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6921297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 15.1010548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 15.1017132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.1011399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.9220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1317292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1316740699
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.1317136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.1316740699
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.2812752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5710548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2016636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.6316636934
MESH:D012640 Seizures Phenobarbital 2.5611442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8119755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.8116467112
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3016517039
MESH:D013119 Spinal Cord Injuries Progesterone 4.0715862959 16503802
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.0612587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.172093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1718456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 6.1716033868
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 6.1717575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 6.1717261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.7716045194 16684133
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.8512837982
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.067505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.061399818
MESH:D013964 Thyroid Neoplasms Tretinoin 11.0617045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.0917053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 8.0915537745
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 8.0914692829
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4916129372
MESH:D014591 Uterine Diseases bisphenol A 4.8014652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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