AutismKB 2.0

Annotation Detail for ANP32B


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Basic Information Top
Gene Symbol:ANP32B ( APRIL,PHAPI2,SSP29 )
Gene Full Name: acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
Band: 9q22.33
Quick LinksEntrez ID:10541; OMIM: NA; Uniprot ID:AN32B_HUMAN; ENSEMBL ID: ENSG00000136938; HGNC ID: 16677
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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No data
Desease Name
systemic lupus erythematosus
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ANP32B mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ANP32B mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ANP32B mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of ANP32B mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ANP32B mRNAdecreases expression 20382639
19150397
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ANP32B mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of ANP32B mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ANP32B mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ANP32B mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANP32B mRNAaffects cotreatment|increases expression 17942748
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of ANP32B mRNAaffects cotreatment|decreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANP32B mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of ANP32B mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of ANP32B mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3719825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3714692618
MESH:D000236 Adenoma Diethylnitrosamine 2.916695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.5819052882 19061943 18056438 17620307 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5816835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.3316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.693084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.6914691202 15073043 16217749 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6918210153 11831363 16569478 17138121 20727157 16540662 19052882 16698587 3084413 21159647 19208518 19171122 10672840 17428255 16935385 3581430 20214788 20007298 17761372 19519916 19919837 18785209 17055752 17978847 18393292 19701751 18971187 16288022 20514400 20524982 18056438 19539802 18978308 19335982 16681979 19394651 18494052 19822196 18665156 20084675 20432363 16830150 17162532 16779866 16328049 16807293 18691550 18506893 10737359 20935162 19107877 17173139 16502159 18788625 19383236 19418558 16878318 20101231 20512989
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.5917174075 2727394 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.6519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.6516835633
MESH:D002779 Cholestasis Cyclosporine 8.0519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0515861022 17110522 16105132 17333356 17681005 11677210 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 8697196 16354765 15340226 15668235
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8315322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8319769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3017107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3415619225 11287661 17906064 11743745 16227642 18071297 19085960 10915739 2444490 11739529 19420014 19416960 19164858 19739265 11834606 11461765 17522070 14725611 12958197 16781746 19923254 11529661 15968718 12705907 12594235 19370779 16109766 10774834 16177239 14550746 16081117 12540782 14986274 12153990 11421492 18713872 16393943 12392966 10663392 16485898 17562736
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.3419107877
MESH:D056486 Drug-Induced Liver Injury Selenium 12.3415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver arsenic trioxide 19.7115073043
MESH:D005234 Fatty Liver Cyclosporine 19.7119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.7121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.7115345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7516080930
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0316120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Diethylnitrosamine 5.0718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712200463 12878042
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.3612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.368314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.3612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007938 Leukemia arsenic trioxide 2.8815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1520471514 17050201 16968895 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2816331271 17107899 15622746 19642359 15748426 17712046 16966277 11468182 19225113 16823087 16330433 17217047 15336539 9834237 17649720 12018890 16891316 16112521 11161223 19035177 12679006 12712474 17869043 19075265 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8820032147 18407596 19638242 18522880 18665156
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3716169303
MESH:D008107 Liver Diseases Acetaminophen 3.9912587719 16611625 16610002 12969438 11587558 19784758 19014921 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 11.0414682389
MESH:D008113 Liver Neoplasms Clofibric Acid 11.0417602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.0418754104 19996281 19254457 20583210 18644402 20137499 19294768 12112319 15175105 19499222 18648771 20405173 20101389 19638242 19812893 16942905 20452335 9163691 18977376 19426721 18978307 19255062 2862719 19256749 20501860 10737359 15885732 21047994 2422723 20492335 21167192 19427195 19642983 19690152 20118626 12771043 21071580 19833225 19850985 21278145 19551842 19073162 20434301 19090486
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.2020377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.2018775883 19004024 18544905 19009564 18079962 17174075 17942915 21159647 18282651 19539802 18164116 2563599 19126423 9362446 18093689 18308698 19519916 16267830 3124819 17854601 18253720 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9319825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9320970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9311884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.9311062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8315318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1814977855 11468182 15949261 19549372 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2016882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.603581430 9029167
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5316049721 12819281
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4419769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3915580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3916540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.2712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.272563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2719131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6018551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4717007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4718456281
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.4719014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.477505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2112845720 12973940 20435036 11780464
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24812
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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