AutismKB 2.0

Annotation Detail for SLC34A2


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Basic Information Top
Gene Symbol:SLC34A2 ( FLJ90534,NAPI-3B,NAPI-IIb,NPTIIb )
Gene Full Name: solute carrier family 34 (sodium phosphate), member 2
Band: 4p15.2
Quick LinksEntrez ID:10568; OMIM: 604217; Uniprot ID:NPT2B_HUMAN; ENSEMBL ID: ENSG00000157765; HGNC ID: 11020
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1761Respiratory tract disease
No data
No data
Desease Name
Testicular microlithiasis
Pulmonary alveolar microlithiasis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC34A2 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SLC34A2 mRNAaffects cotreatment|decreases expression 18164116
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SLC34A2 proteindecreases expression 17544377
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SLC34A2 mRNAaffects cotreatment|decreases expression 18164116
D004281 Docosahexaenoic Acids PPARA protein promotes the reaction [Docosahexaenoic Acids results in decreased expression of SLC34A2 mRNA]decreases expression|increases reaction 18489776
D015118 Eicosapentaenoic Acid PPARA protein promotes the reaction [Eicosapentaenoic Acid results in decreased expression of SLC34A2 mRNA]decreases expression|increases reaction 18489776
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC34A2 mRNAincreases expression 12072388
D005632 Fructose Fructose affects the expression of SLC34A2 mRNAaffects expression 15150374
D005632 Fructose Fructose results in decreased expression of SLC34A2 mRNAdecreases expression 18400728
D005632 Fructose tungstate promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]decreases expression|increases reaction 18400728
D005632 Fructose Vanadates promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]decreases expression|increases reaction 18400728
C029938 nickel sulfate nickel sulfate results in decreased expression of SLC34A2 mRNAdecreases expression 16100012
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of SLC34A2 mRNAaffects expression 15143139
D016226 Phosphorus, Dietary Phosphorus, Dietary results in decreased expression of SLC34A2 mRNAdecreases expression 17596124
C006253 pirinixic acid pirinixic acid results in decreased expression of SLC34A2 mRNAdecreases expression 17426115
C045951 tungstate tungstate promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]decreases expression|increases reaction 18400728
D014638 Vanadates Vanadates promotes the reaction [Fructose results in decreased expression of SLC34A2 mRNA]decreases expression|increases reaction 18400728
C025643 vinclozolin vinclozolin affects the expression of SLC34A2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury nickel sulfate 9.3416100012 19131640 12718980 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 9.3418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.9819389873
MESH:D000236 Adenoma Diethylnitrosamine 6.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.3717162532 17620307 18056438 19052882 16434500 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3716434500
MESH:D001008 Anxiety Disorders vinclozolin 3.6819015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Docosahexaenoic Acids 3.1918582451
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2317474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.853786805 16124888 16227642 16011737 15700767 10355542 16097048 16192424 15673190 18705752 15721981 16050911
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.0416878318 19383236 17173139 17761372 16288022 20007298 3084413 17428255 10672840 18494052 18971187 21159647 18665156 19822196 16935385 18785209 16569478 18506893 20514400 19394651 19171122 16807293 20727157 17162532 17055752 18056438 20512989 19335982 18210153 20935162 17978847 16681979 19208518 19107877 19539802 11831363 16502159 18691550 16540662 20432363 19701751 20524982 10737359 20084675 18393292 3581430 16830150 20101231 19052882 19519916 17138121 16779866 18788625 18978308 20214788 16328049 19919837 16698587 19418558
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.8917174075 7505956 2727394 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7319052882
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8816919318 15861022 16105132 17110522 17333356 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 7.8819176532
MESH:D003327 Coronary Disease Fructose 4.5118504504
MESH:D003456 Cryptorchidism vinclozolin 4.4114966744
MESH:D003550 Cystic Fibrosis Docosahexaenoic Acids 4.7219747007
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.7416780908 16823706 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.5418603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.8920387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 4.8918603373
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9610092053 3786805 10915739 15998439 2869522 16227642 19085960 9327722 15968718 3732212 16177239 19336974 21278145 11566570 4309450 7440962 17522070 6884620 6623471 7179309 15027814 7120509
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9619107877
MESH:D004362 Drug Toxicity marker/mechanism 15805072
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.2919224547 16045604 15959796 17595544 12795759 16239168 12631006 61145
MESH:D005234 Fatty Liver Diethylnitrosamine 25.2920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.2915345470
MESH:D005234 Fatty Liver Fructose 25.2919196556 18395287 18641190
MESH:D005234 Fatty Liver pirinixic acid 25.2920131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4718705752
MESH:D005355 Fibrosis Fructose 9.4718504504
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D018149 Glucose Intolerance Fructose 5.3819165636
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.0719772884 16221962 18467677 19176532
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006946 Hyperinsulinism Fructose 4.9415752949 19008412 18360027 14757778 18563319
MESH:D006949 Hyperlipidemias Fructose 4.8115752949
MESH:D006973 Hypertension Fructose 3.6314633139 16843071 19008412 14573337 14568997
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D015228 Hypertriglyceridemia Fructose 5.1319342510 19799862
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7817937319
MESH:D007248 Infertility, Male vinclozolin 6.7816467254
MESH:D007249 Inflammation Diethylnitrosamine 2.4018785209
MESH:D007333 Insulin Resistance Fructose 7.7818563319 19342510 14633139 14757778 18057795 19008412 19586609 19799862 14573337 17133782 18981581
MESH:D007333 Insulin Resistance pirinixic acid 7.7816306350
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Docosahexaenoic Acids 5.0517077332
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8116417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7016943688 21278145 17157831 16221502 11903743 16239168 17174718 17334410 11408273
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7018522880 20032147 18665156 18407596 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3412445421 16011737 12632512 16097048 12666154 17976157 18429990 14620537 18395914 14724832 18472094 16033810 18339082 12445418 16015684 10355542 12667390 17944888 15730626 11481614 18376398 18263696 18418968 17721639 12546737 12609069 17631135 18166357 12649538 16638106 12741479 18705752 15673190 15893842 17766677 15650968 15996030 18481824 17640975 18006644 17557913 18317297 18472332 15876570 17869086 15370692 18187930 20821823 12632514 18279442 14748882 14716833 16136751 14512876 17708605 18205269 17805973 15931870 14716496 18054572 12898905 17900296 18412020 17698563 15338365 17922224 12586293 15959796 16192424 12389079 16027843 15925388 15123356 15057751 18251166 13678700 15818738 16116963 17761835 15052691 16248980 18395095 15362042 18420326 18210741 17565644 17525996 18277467 12958196 17823541 18156304 17714472 17481882
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3415474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7916246199 16964402 15830285 15720792 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7917034775
MESH:D008107 Liver Diseases Docosahexaenoic Acids 6.7917056761
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7414706259 16899240
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 10.8821295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.8819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.8819638242 19551842 20501860 18648771 18978307 21167192 10737359 21071580 19833225 19690152 16942905 18644402 19427195 2862719 21047994 19642983 15885732 18977376 21278145 12112319 19256749 15175105 20492335 19294768 9163691 19996281 20118626 19426721 19499222 20583210 20452335 19090486 19812893 19850985 19073162 18754104 20405173 20101389 12771043 19255062 19254457 20137499 2422723 20434301
MESH:D008113 Liver Neoplasms pirinixic acid 10.8816377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.1218164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.1212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.1219539802 2563599 19519916 19126423 18308698 17174075 18282651 3124819 16842330 21159647 19009564 18164116 9362446 18544905 16267830 17942915 17854601 19004024 18775883 18079962 18253720 18093689
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 20970405 6695378 20512841
MESH:D024821 Metabolic Syndrome X Fructose 4.8618497449 17261469 16815490 17098227 19165636
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9717405874
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009765 Obesity Fructose 4.8917707055 18585860
MESH:D009765 Obesity pirinixic acid 4.8920558911
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9818042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
OMIM:265100 PULMONARY ALVEOLAR MICROLITHIASIS marker/mechanism
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.9018456281
MESH:D013274 Stomach Neoplasms Docosahexaenoic Acids 2.9019015929
OMIM:610441 TESTICULAR MICROLITHIASIS marker/mechanism
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.027505956
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5915869587 14671159
Pathway ID Pathway Name
KEGG:04978 Mineral absorption
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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