AutismKB 2.0

Annotation Detail for TACC2


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Basic Information Top
Gene Symbol:TACC2 ( AZU-1,ECTACC )
Gene Full Name: transforming, acidic coiled-coil containing protein 2
Band: 10q26.13
Quick LinksEntrez ID:10579; OMIM: 605302; Uniprot ID:TACC2_HUMAN; ENSEMBL ID: ENSG00000138162; HGNC ID: 11523
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TACC2 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TACC2 mRNAdecreases expression 20382639
19150397
D016572 Cyclosporine Cyclosporine results in increased expression of TACC2 mRNAincreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of TACC2 mRNAincreases expression 16144939
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of TACC2 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TACC2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of TACC2 mRNAincreases expression 18301758
18445702
D011374 Progesterone Progesterone results in increased expression of TACC2 mRNAincreases expression 18037150
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of TACC2 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of TACC2 mRNAaffects cotreatment|decreases expression 19059307
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of TACC2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000419 Albuminuria Raloxifene 4.7917451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6417659584
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617507914 18940202 17688650 16609825 20603192 18177632 17157402 15238991 18316065 18558336 18775368 19460635 18396377 19232924 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 11.7015665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 11.7016580743
MESH:D001943 Breast Neoplasms Progesterone 1.9817614352 16175315 15562024
MESH:D001943 Breast Neoplasms Raloxifene 1.9817952589 15572757 16837676 17440819 17595753 15758505 17049068 17893378 16912660 15775269 17242785 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 1.9816873071 20065188 17261762 16818667 19200415 18984771 21152245 16202921 17049068 18629630 19410462 16273361 20859285 19059307 15668708 18815881 20390343 19155303 17440819 19084267 18425577 20005174 21138602 17893378 19011961 18821012 19288272 19244106 19487384 19066611 18997820 19289846 11161223 19189210 20544844 19103187 19221464 18351453 15565566 19189212 20135344 19142967 17242785 18855134 19115204
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 2.9116924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.0417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.0417572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5615775269
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9412371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D003072 Cognition Disorders Raloxifene 4.8315800139
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5215824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.8917728286
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.8916575769 17688650 8888407
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3117474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.6112438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003928 Diabetic Nephropathies Raloxifene 9.5517308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.5519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D003967 Diarrhea Dexamethasone 3.897237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9411461765 10915739 11529661 12594235 10663392 16109766 12540782 12705907 11743745 16081117 12153990 19739265 18713872 11287661 14725611 12392966 16781746 10774834 19416960 19370779 11739529 17906064 14550746 2444490 17562736 19420014 11421492 16485898 15619225 12958197 11834606 19085960 15968718 16227642 19923254 16393943 18071297 19164858 14986274 16177239 17522070
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.941733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004485 Eczema Dexamethasone 4.6612438553
MESH:D004487 Edema Dexamethasone 12.5919703484
MESH:D004487 Edema pirinixic acid 12.5912083418
MESH:D004487 Edema Raloxifene 12.5915860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.6317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 16.6315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.6319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1520544844 19155303 17893378 16202921
MESH:D004715 Endometriosis Progesterone 3.9316134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005234 Fatty Liver Cyclosporine 26.6219224547
MESH:D005234 Fatty Liver pirinixic acid 26.6219236843 20131406
MESH:D005234 Fatty Liver Raloxifene 26.6217473493
MESH:D005234 Fatty Liver Tamoxifen 26.6219224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 26.6219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3318558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Cyclosporine 3.3612168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006331 Heart Diseases Raloxifene 3.6511110106
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2116221962 19772884 18467677 19176532
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.127520565
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 9.0610903974
MESH:D006973 Hypertension Dexamethasone 9.0617042910
MESH:D006973 Hypertension Raloxifene 9.0615787275 17577099
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007249 Inflammation Dexamethasone 8.928960868 11099482
MESH:D007249 Inflammation Progesterone 8.9215869954
MESH:D007249 Inflammation Tamoxifen 8.9219457130
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.108314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.7818625569
MESH:D007889 Leiomyoma Raloxifene 4.6816973256
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D008064 Lipidoses Tamoxifen 3.2715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.6216718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6215474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6218564211
MESH:D008107 Liver Diseases Acetaminophen 1.6616610002 19784758 19460945 16611625 11587558 12969438 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.6220007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 4.6216684651
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Dexamethasone 2.6711195469 15824018
MESH:D008175 Lung Neoplasms Tamoxifen 2.6718625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4311408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4314580682 19196723 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8215863610
MESH:D009101 Multiple Myeloma Dexamethasone 7.9615867202 15744524 16118317
MESH:D009101 Multiple Myeloma Raloxifene 7.9616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.879809623
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.8717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009232 Myxoma Raloxifene 5.8216343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010024 Osteoporosis Raloxifene 3.4919059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4117893378 15579764 17823083 15758505
MESH:D010051 Ovarian Neoplasms Progesterone 2.5716525653 17393432
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6321297632
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3216536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3215067354
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011693 Purpura Raloxifene 5.8215770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.2018379247 11700416
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.853137016 16876388 17978042 14763951 11738929 11044598 1511512 15475178
MESH:D013088 Spermatocele Tamoxifen 4.5616709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.6815862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.6819457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013272 Stomach Diseases Dexamethasone 4.5615472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.6515138204
MESH:D020521 Stroke Raloxifene 3.9616837676
MESH:D013978 Tibial Fractures Raloxifene 5.4719048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.4317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.4317572228 8653321 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 12.671336536
MESH:D014605 Uveitis Dexamethasone 12.671336536
MESH:D054556 Venous Thromboembolism Raloxifene 5.4716837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8216343187
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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