AutismKB 2.0

Annotation Detail for SORBS1


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Basic Information Top
Gene Symbol:SORBS1 ( CAP,DKFZp451C066,DKFZp586P1422,FLAF2,FLJ12406,KIAA1296,R85FL,SH3D5,SH3P12,SORB1 )
Gene Full Name: sorbin and SH3 domain containing 1
Band: 10q24.1
Quick LinksEntrez ID:10580; OMIM: 605264; Uniprot ID:SRBS1_HUMAN; ENSEMBL ID: ENSG00000095637; HGNC ID: 14565
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa03320PPAR signaling pathway
hsa04520Adherens junction
Pathway IDPathway Name
Muscle contraction
Pathway IDPathway Name
200012Insulin Pathway
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2102Polycystic ovary syndrome
Desease Name
METABOLIC
diabetes, type 2
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SORBS1 mRNAdecreases expression 20064835
20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of SORBS1 mRNAdecreases expression 20106945
D005047 Etoposide SORBS1 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D019833 Genistein Genistein results in increased expression of SORBS1 mRNAincreases expression 18847459
C008493 methylselenic acid methylselenic acid results in increased expression of SORBS1 mRNAincreases expression 18548127
D016685 Mitomycin SORBS1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D008942 Mitoxantrone SORBS1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C006253 pirinixic acid pirinixic acid results in decreased expression of SORBS1 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of SORBS1 mRNAincreases expression 16985257
18301758
D011794 Quercetin Quercetin results in increased expression of SORBS1 mRNAincreases expression 17103110
C004648 testosterone enanthate testosterone enanthate affects the expression of SORBS1 mRNAaffects expression 17440010
D014635 Valproic Acid Valproic Acid results in increased expression of SORBS1 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of SORBS1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.648875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5120464547 20127859
MESH:D000230 Adenocarcinoma Genistein 4.5111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000743 Anemia, Hemolytic Quercetin 4.3517084956
MESH:D001008 Anxiety Disorders Valproic Acid 9.1517497229
MESH:D001008 Anxiety Disorders vinclozolin 9.1519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1315336622
MESH:D001321 Autistic Disorder Valproic Acid 2.0018558336 18316065 20603192 19232924 15238991 19460635 18985861 17688650 18940202 18177632 18396377 17507914 16609825 18775368 17157402
MESH:D001327 Autoimmune Diseases Quercetin 4.5519761891
MESH:D001714 Bipolar Disorder Valproic Acid 3.1317594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.478888407
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.3414601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0420146248 17474063
MESH:D001943 Breast Neoplasms Etoposide 2.0416322251
MESH:D001943 Breast Neoplasms Genistein 2.0416541309 16873071 17200150
MESH:D001943 Breast Neoplasms Quercetin 2.0418628248
MESH:D002105 Cadmium Poisoning Quercetin 5.7216962696
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.3316924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.3319519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0917234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Quercetin 3.3719794523
MESH:D002318 Cardiovascular Diseases Genistein 3.3816332659
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6012371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D003110 Colonic Neoplasms Genistein 3.9817182828
MESH:D003110 Colonic Neoplasms Quercetin 3.9816640504 19440933 11134977 15741050 17191121 19056647 17148506
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8219496084
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5116647724
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2019641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004714 Endometrial Hyperplasia Genistein 4.7416402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4311473722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.293659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.686426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005234 Fatty Liver Cyclosporine 13.7219224547
MESH:D005234 Fatty Liver pirinixic acid 13.7219236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 13.7214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.268888407 18558336
MESH:D005355 Fibrosis Cyclosporine 9.3012168785 12639820
MESH:D005355 Fibrosis Quercetin 9.3019474275
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Genistein 7.5816598420
MESH:D005909 Glioblastoma Quercetin 7.5819804834
MESH:D005910 Glioma Quercetin 3.0917643826
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006331 Heart Diseases Mitoxantrone 4.2216019553
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1319176532 18467677 16221962 19772884
MESH:D006561 Herpes Simplex Etoposide 4.7210809021
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9217440010
MESH:D006689 Hodgkin Disease Etoposide 3.9615147373 18180244 17606976 16200630 16135485
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006943 Hyperglycemia pirinixic acid 9.5920558911
MESH:D006943 Hyperglycemia Quercetin 9.5918262572 11834736
MESH:D006973 Hypertension Cyclosporine 5.4210903974
MESH:D006973 Hypertension Quercetin 5.4218356687
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007251 Influenza, Human Quercetin 4.6816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007627 Keloid Quercetin 5.0917086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.3218776723 10903974 8314463
MESH:D007674 Kidney Diseases Quercetin 6.3216962696
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D007938 Leukemia Genistein 6.7217468513 18980019
MESH:D007938 Leukemia Quercetin 6.7217468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8318172266
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.6217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6215474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.6212741479
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0820195826 21137059
MESH:D008113 Liver Neoplasms Mitomycin 11.0815113037
MESH:D008113 Liver Neoplasms pirinixic acid 11.0815890375 16377806 20007298
MESH:D008113 Liver Neoplasms Quercetin 11.0818980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.1219519916
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5620064080 18520028 18816296 17053015 20135361 18569708 20464547 6695378 20869020
MESH:D008175 Lung Neoplasms Quercetin 2.5616280456
MESH:D008223 Lymphoma Etoposide 4.0012556972 12854902
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0114578162 12929590
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2718765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D009203 Myocardial Infarction Genistein 9.7417141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.7419151258
MESH:D009203 Myocardial Infarction Quercetin 9.7419595682
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.7417141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.7416411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 14.7419207477
MESH:D009369 Neoplasms Benzo(a)pyrene 12.3411141357
MESH:D009369 Neoplasms Mitoxantrone 12.3416640825
MESH:D009369 Neoplasms pirinixic acid 12.3417405874
MESH:D009369 Neoplasms Quercetin 12.3415185748
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Genistein 4.1616427766
MESH:D009436 Neural Tube Defects Valproic Acid 3.208888407 16359493
MESH:D020078 Neurogenic Inflammation Quercetin 4.4817929310
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010024 Osteoporosis Genistein 3.3219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.5416169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.5419495926
MESH:D010051 Ovarian Neoplasms Genistein 5.1919005980
MESH:D010051 Ovarian Neoplasms Quercetin 5.1919005980
MESH:D010190 Pancreatic Neoplasms Etoposide 9.1219003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 9.1215113037
MESH:D010190 Pancreatic Neoplasms Quercetin 9.1216965848
MESH:D011230 Precancerous Conditions Cyclosporine 9.4312371664
MESH:D011230 Precancerous Conditions Quercetin 9.4319056647
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.2420603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2418220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Etoposide 1.8917172428
MESH:D011471 Prostatic Neoplasms Genistein 1.8915378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.8916205645
MESH:D011471 Prostatic Neoplasms Quercetin 1.8917292933 14715546
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.7111422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012512 Sarcoma, Ewing's Etoposide 4.8314601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.7216862918
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8115475178 11044598 11738929 14763951 1511512 3137016 17978042 16876388
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4110029692 19755658
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2917053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.2916720314
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04910 Insulin signaling pathway
REACT:17044 Muscle contraction
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37899
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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