AutismKB 2.0

Annotation Detail for IFITM2


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Basic Information Top
Gene Symbol:IFITM2 ( 1-8D )
Gene Full Name: interferon induced transmembrane protein 2 (1-8D)
Band: 11p15.5
Quick LinksEntrez ID:10581; OMIM: 605578; Uniprot ID:IFM2_HUMAN; ENSEMBL ID: ENSG00000185201; HGNC ID: 5413
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of IFITM2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IFITM2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IFITM2 mRNAaffects expression 16483693
D001151 Arsenic IFITM2 mRNA results in decreased susceptibility to Arsenicdecreases response to substance 17976673
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of IFITM2 mRNAdecreases expression 15336504
D002104 Cadmium Cadmium results in increased expression of IFITM2 mRNAincreases expression 17547211
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of IFITM2 mRNAincreases expression 17547211
C459604 candoxin candoxin results in decreased expression of IFITM2 mRNAdecreases expression 16309724
D016572 Cyclosporine Cyclosporine results in decreased expression of IFITM2 mRNAdecreases expression 20106945
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of IFITM2 mRNAincreases expression 17547211
D005419 Flavonoids Flavonoids results in increased expression of IFITM2 mRNAincreases expression 18035473
C010176 halofuginone halofuginone results in increased expression of IFITM2 mRNAincreases expression 17180598
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of IFITM2 mRNAaffects cotreatment|increases expression 17183730
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of IFITM2 promoteraffects acetylation|affects methylation 18448484
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IFITM2 mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in increased expression of IFITM2 mRNAincreases expression 19244175
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of IFITM2 promoteraffects acetylation|affects methylation 18448484
C017947 sodium arsenite sodium arsenite results in decreased expression of IFITM2 mRNAdecreases expression 12377979
C446685 systhane systhane results in increased expression of IFITM2 mRNAincreases expression 16643972
C032910 triadimefon triadimefon results in increased expression of IFITM2 mRNAincreases expression 16643972
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of IFITM2 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in increased expression of IFITM2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.388875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8319490988
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 2.8616033868
MESH:D000236 Adenoma Dimethylnitrosamine 3.4919555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.3716434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5915276417
MESH:D018246 Adrenocortical Adenoma Arsenic 13.4417306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 13.4416712894 17306315
MESH:D000550 Amblyopia Valproic Acid 5.1317688650
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.4817497229
MESH:D020261 Arsenic Poisoning Arsenic 2.8418414634 12569548 16835338 16251483
MESH:D050197 Atherosclerosis Arsenic 6.8112928151 19371607
MESH:D050197 Atherosclerosis Cadmium 6.8115687053
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517507914 18396377 18985861 18177632 18316065 19232924 18558336 16609825 20603192 17157402 15238991 18940202 17688650 19460635 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.0220046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0419483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.338888407
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8216050911
MESH:D002277 Carcinoma Dimethylnitrosamine 3.9319555203
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5317687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.443084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.4412619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.4416507464 17306315
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.4415276417 17306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.5017687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 7.5016033868
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.5018572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.9818640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.3715738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.2116973168 18022660
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic Cadmium 15.4917332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.4912371664
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 15.4919716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.4919524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6720734317
MESH:D002779 Cholestasis Cyclosporine 7.4919486331
MESH:D002779 Cholestasis pirinixic acid 7.4919176532
MESH:D002972 Cleft Palate triadimefon 3.6816781842
MESH:D003092 Colitis Selenium 3.6717936198
MESH:D019465 Craniofacial Abnormalities triadimefon 3.9316875885 15834900
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9316575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9319769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.7512153990 17906064 19164858 11461765 12392966 12958197 11743745 14725611 11529661 16109766 11739529 11287661 16485898 10915739 10663392 11421492 19370779 12705907 17562736 19420014 12594235 16227642 14550746 14986274 12540782 15968718 16393943 16081117 18713872 17522070 2444490 19085960 19923254 16781746 10774834 19416960 15619225 11834606 16177239 18071297 19739265
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 8.758172417
MESH:D056486 Drug-Induced Liver Injury Selenium 8.7515131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.751733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004421 Dystonia Valproic Acid 3.941851702
MESH:C538011 Eales disease Vitamin E 4.609068938
MESH:D004487 Edema pirinixic acid 2.3812083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.043659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.8116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8818234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.496254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.963659116
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 2.8817016578
MESH:D005234 Fatty Liver Cyclosporine 12.4819224547
MESH:D005234 Fatty Liver pirinixic acid 12.4819236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 12.4814986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.7816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.028888407 18558336
MESH:D005355 Fibrosis Cyclosporine 3.0312168785 12639820
MESH:D005534 Foot Diseases Arsenic 5.456392382
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9316080930
MESH:D006333 Heart Failure pirinixic acid 6.7320558911
MESH:D006333 Heart Failure Selenium 6.7317162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006529 Hepatomegaly pirinixic acid 14.1416221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly systhane 14.1417178689 17178688
MESH:D006529 Hepatomegaly triadimefon 14.1417178688 17178689
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 3.0612676792
MESH:D019584 Hot Flashes Vitamin E 3.8714716179
MESH:D006849 Hydrocephalus Valproic Acid 4.7617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3617050553
MESH:D006965 Hyperplasia halofuginone 5.1411874485
MESH:D006973 Hypertension Arsenic 5.1616076760 9931084 11953799
MESH:D006973 Hypertension Cyclosporine 5.1610903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.5216612254
MESH:D006987 Hypesthesia Arsenic 5.4516093927
MESH:D007248 Infertility, Male sodium arsenite 2.9212646999 15346721
MESH:D007249 Inflammation Flavonoids 2.5917296493
MESH:D007251 Influenza, Human Selenium 10.6116624496
MESH:D007251 Influenza, Human Vitamin E 10.6116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5616306350
MESH:D007569 Jaw Abnormalities triadimefon 4.8615992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007642 Keratosis Arsenic 4.8812749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 23.0615629191 12587719
MESH:D007674 Kidney Diseases Cadmium 23.0616962696 16226777 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 23.0616962696
MESH:D007674 Kidney Diseases Cyclosporine 23.068314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 23.0620008137
MESH:D007674 Kidney Diseases Vitamin E 23.0612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7816518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6412371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1316294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4817339181
MESH:D008103 Liver Cirrhosis halofuginone 3.9717180598
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 4.9416544323 18364076 16270385 18095165 15842777 17348192 12918455 18672772 15339415 18237412 17640959 15492853 15733078 14709902 18371158 15864749 15366600 15086199 17196135 15763062 15298665 15138612 16603200 17881167 18567088 17432682 18637143 16042886 15383259 17036385 16570917 15942678 15723089 15067225 14726149 15099470 17198567 18210741 15591649 12925901 17724770 17719030 14568256 17465448 18629640 15479170 15798949 14659978 18239293 15081153 17534399 17666798 15504291 16009107 15161499 16627068 15571005 14643895 17201889 15793283 16169303 17203207 15577212 15369754 15744066
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 4.9418458672 14739098 11172339 12175628 16489207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9415474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.9416169303
MESH:D008107 Liver Diseases Acetaminophen 6.5219784758 11587558 12969438 12587719 19460945 16610002 19014921 16611625
MESH:D008107 Liver Diseases Arsenic 6.5211134558
MESH:D008107 Liver Diseases triadimefon 6.5219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 9.3516871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.3517457977
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.479163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Arsenic 17.4716368122
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 17.473113478 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 17.4715890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 17.4716712894 15276417
MESH:D008113 Liver Neoplasms triadimefon 17.4719028983
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.738603461
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 13.7315603536 6150874 1848544
MESH:D008114 Liver Neoplasms, Experimental systhane 13.7317178689
MESH:D008114 Liver Neoplasms, Experimental triadimefon 13.7317178689
MESH:D008171 Lung Diseases sodium arsenite 7.2019095001
MESH:D008171 Lung Diseases Vitamin E 7.2016863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1617228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.4714755239
MESH:D008175 Lung Neoplasms Arsenic 6.4717306315 19168569 17976673
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 6.4716061637 11884234 19555203
MESH:D008175 Lung Neoplasms sodium arsenite 6.4717306315 19931552 16712894 17077188 15276417
MESH:D008175 Lung Neoplasms Vitamin E 6.4711062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.6915318939
MESH:D008545 Melanoma sodium arsenite 2.0219082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008654 Mesothelioma Selenium 2.7515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1118803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.928888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D017202 Myocardial Ischemia Arsenic 3.8915371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8616411023
MESH:D009369 Neoplasms pirinixic acid 4.7617405874
MESH:D009369 Neoplasms sodium arsenite 4.7611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5620056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1919348381 18481113
MESH:D009436 Neural Tube Defects Arsenic 11.8016620997
MESH:D009436 Neural Tube Defects sodium arsenite 11.8012854658
MESH:D009436 Neural Tube Defects Valproic Acid 11.808888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7818514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.2717056641
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D010051 Ovarian Neoplasms Arsenic 4.9217306315
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9215276417 17306315
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0716093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 12.7216905509 6392382 15371236
MESH:D016491 Peripheral Vascular Diseases Cadmium 12.7215687053
MESH:D010954 Plasmacytoma Selenium 4.7815087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.1312371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.7220603192
MESH:D011471 Prostatic Neoplasms Arsenic 2.1516140617
MESH:D011471 Prostatic Neoplasms Cadmium 2.1517075824
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1516039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1515084515
MESH:D011507 Proteinuria Arsenic 3.9021343184
MESH:D019310 Pseudolymphoma Valproic Acid 4.4412752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0719155313
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012640 Seizures Valproic Acid 2.6611044598 17978042 3137016 11738929 14763951 16876388 1511512 15475178
MESH:D012871 Skin Diseases Arsenic 11.2019834688 17453740 16702368 6392382 17050553 17548696 17938729 15952646 16759981 18709164 16353154
MESH:D012871 Skin Diseases halofuginone 11.2011874485
MESH:D012871 Skin Diseases monomethylarsonous acid 11.2017431481
MESH:D012871 Skin Diseases Vitamin E 11.2018709164
MESH:D012878 Skin Neoplasms Arsenic 9.2717029826 15504454 17976673 16251483 17050553 19538983
MESH:D012878 Skin Neoplasms sodium arsenite 9.2719524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.278532709
MESH:D016135 Spinal Dysraphism sodium arsenite 9.2612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.2619490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.1612587719
MESH:D013226 Status Epilepticus Valproic Acid 4.4412833885
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.4516033868
MESH:D020521 Stroke Vitamin E 3.4316517955
MESH:D013964 Thyroid Neoplasms triadimefon 4.0017178689
MESH:D014178 Translocation, Genetic Valproic Acid 5.1317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.413119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.2919322015 17306315 11144890 19429237 17976673 18640142 15987713
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 8.2920375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.2916712894 11723127 17306315 16452187
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.538888407
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6711813266
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D014652 Vascular Diseases Arsenic 11.4817056641
MESH:D014652 Vascular Diseases sodium arsenite 11.4817056641
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
KEGG:04662 B cell receptor signaling pathway
REACT:6900 Signaling in Immune system
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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