AutismKB 2.0

Annotation Detail for TXNRD2


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Basic Information Top
Gene Symbol:TXNRD2 ( SELZ,TR,TR-BETA,TR3,TRXR2 )
Gene Full Name: thioredoxin reductase 2
Band: 22q11.21
Quick LinksEntrez ID:10587; OMIM: 606448; Uniprot ID:TRXR2_HUMAN; ENSEMBL ID: ENSG00000184470; HGNC ID: 18155
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
THIOREDOX-PWYthioredoxin pathway
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
2022Liver cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C067134 8-oxo-7-hydrodeoxyguanosine TXNRD2 gene SNP affects the abundance of 8-oxo-7-hydrodeoxyguanosineaffects abundance 19896490
D000082 Acetaminophen Acetaminophen affects the expression of TXNRD2 mRNAaffects expression 17562736
D001310 Auranofin Auranofin results in decreased activity of TXNRD2 proteindecreases activity 15458826
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TXNRD2 mRNAincreases expression 14729362
15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TXNRD2 mRNAaffects expression 16239168
D016572 Cyclosporine Cyclosporine results in decreased expression of TXNRD2 mRNAdecreases expression 20106945
C074283 estradiol 3-benzoate estradiol 3-benzoate results in increased expression of TXNRD2 mRNAincreases expression 14967907
D017612 Gold Compounds Gold Compounds results in decreased activity of TXNRD2 proteindecreases activity 15458826
D006052 Gold Sodium Thiomalate Gold Sodium Thiomalate results in decreased activity of TXNRD2 proteindecreases activity 15458826
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of TXNRD2 mRNAincreases expression 14729362
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TXNRD2 mRNAincreases expression 19339665
D008070 Lipopolysaccharides methyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of TXNRD2 mRNA]increases expression|increases reaction 19339665
D008627 Mercuric Chloride Mercuric Chloride results in decreased activity of TXNRD2 proteindecreases activity 17157198
D008628 Mercury Mercury results in decreased activity of TXNRD2 proteindecreases activity 17157198
C008435 methyldithiocarbamate methyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of TXNRD2 mRNA]increases expression|increases reaction 19339665
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TXNRD2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of TXNRD2 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of TXNRD2 mRNAincreases expression 18301758
C045950 propiconazole propiconazole affects the expression of TXNRD2 mRNAaffects expression 17383973
D012643 Selenium Selenium results in increased activity of TXNRD2 proteinincreases activity 15471857
D012643 Selenium Selenium deficiency results in decreased expression of TXNRD2 mRNAdecreases expression 15792362
17291446
D012643 Selenium Selenium results in increased expression of TXNRD2 mRNAincreases expression 15792362
D012645 Selenomethionine Selenomethionine affects the expression of TXNRD2 mRNAaffects expression 17222674
D043343 Testosterone Propionate Testosterone Propionate results in increased expression of TXNRD2 mRNAincreases expression 14967907
C016797 triethyl phosphine gold triethyl phosphine gold results in decreased activity of TXNRD2 proteindecreases activity 15458826
D014303 Trinitrotoluene Trinitrotoluene affects the expression of TXNRD2 mRNAaffects expression 21346803
D014415 Tunicamycin Tunicamycin results in decreased expression of TXNRD2 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.286195326
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 8.287525203
MESH:D058186 Acute Kidney Injury Mercuric Chloride 5.0311274264
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.5718653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.5718653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.6116434500
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001168 Arthritis Gold Compounds 7.1816791640
MESH:D001172 Arthritis, Rheumatoid Auranofin 4.5016510263
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.7216634805
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0119483382
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6310355542 16227642 3786805 15721981 16192424 15673190 16050911 16124888 18705752 15700767 16011737 16097048
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.403084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.4018788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.406705139 20935162 20007298 1701930 17173139
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4010334427
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4116936243
MESH:D002386 Cataract Acetaminophen 7.2210977129
MESH:D002386 Cataract Trinitrotoluene 7.2215817613 14694615
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.4212371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.104080065
MESH:D002779 Cholestasis Cyclosporine 7.3919486331
MESH:D002779 Cholestasis pirinixic acid 7.3919176532
MESH:D003092 Colitis Selenium 3.6317936198
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.2715095906
MESH:D003490 Cyanosis Trinitrotoluene 4.7718551238
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.6516823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.6411287661 10774834 11739529 15619225 12705907 16781746 12540782 17906064 18071297 19416960 12153990 11421492 11743745 16485898 10915739 19164858 14550746 11461765 18713872 17522070 10663392 12958197 11529661 16227642 12594235 12392966 19085960 19739265 19420014 19370779 15968718 16081117 14986274 14725611 19923254 16177239 16393943 17562736 11834606 2444490 16109766
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.6415998439 6884620 19085960 10092053 7440962 21278145 16227642 6623471 7120509 17522070 3786805 7179309 16177239 15968718 11566570 10915739 19336974 9327722 3732212 15027814 2869522 4309450
MESH:D056486 Drug-Induced Liver Injury Selenium 8.6415131321
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 8.6421346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004421 Dystonia Phenobarbital 3.861851702
MESH:D004487 Edema pirinixic acid 2.3512083418
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2415328337 17637181 15821434
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.963659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.723922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.416401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.107750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.873659116
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.2417595544 16239168 61145 12631006 16045604 15959796 12795759 19224547
MESH:D005234 Fatty Liver Cyclosporine 12.2419224547
MESH:D005234 Fatty Liver pirinixic acid 12.2420131406 19236843
MESH:D005334 Fever Lipopolysaccharides 3.889205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1718705752
MESH:D005355 Fibrosis Cyclosporine 8.1712168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D006030 Glycosuria, Renal Mercuric Chloride 5.742918855
MESH:D006333 Heart Failure pirinixic acid 6.6420558911
MESH:D006333 Heart Failure Selenium 6.6417162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2516366002
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 19.5416109766
MESH:D006529 Hepatomegaly pirinixic acid 19.5419772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly propiconazole 19.5417178689 17178688
MESH:D006529 Hepatomegaly Trinitrotoluene 19.5415817613
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006973 Hypertension Cyclosporine 2.0410903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D007248 Infertility, Male Trinitrotoluene 3.5812150543
MESH:D007249 Inflammation Lipopolysaccharides 2.8012878042 17963957 17255318 9205823 17237260
MESH:D007251 Influenza, Human Selenium 4.0516624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4917255318
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Acetaminophen 9.6012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.608314463 10903974 18776723
MESH:D007674 Kidney Diseases Mercury 9.6017934191
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.5716518626
MESH:D007676 Kidney Failure, Chronic Selenium 9.5716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6112371664
MESH:D007970 Leukopenia Lipopolysaccharides 4.5515821434
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3611408273 11903743 21278145 16943688 17334410 17157831 16239168 17174718 16221502
MESH:D008103 Liver Cirrhosis Phenobarbital 6.3621047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4215730626 12586293 15818738 15876570 15123356 17976157 15362042 16033810 18395914 15931870 18205269 17631135 17714472 12667390 17721639 14724832 17557913 18472094 16027843 17525996 17805973 16638106 15338365 12741479 10355542 17640975 15673190 12445421 18210741 20821823 18251166 17823541 18429990 17922224 12546737 16136751 18376398 15996030 18339082 17698563 17708605 11481614 18412020 18054572 18279442 15893842 12898905 18263696 12632514 12445418 16248980 18395095 17761835 17481882 18420326 18472332 15925388 15052691 12632512 18277467 13678700 16015684 12958196 17766677 14748882 16116963 15057751 18705752 18317297 18156304 16192424 15959796 17944888 16097048 17869086 16011737 18187930 17565644 12389079 14512876 14620537 14716496 17900296 14716833 15650968 12666154 12649538 12609069 18166357 18481824 18006644 15370692 18418968
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.4212878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4215474484
MESH:D008107 Liver Diseases Acetaminophen 9.1016610002 19784758 11587558 19014921 12587719 12969438 16611625 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.1016246199 17285989 15720792 16964402 15830285
MESH:D008107 Liver Diseases Phenobarbital 9.1019363144
MESH:D008107 Liver Diseases propiconazole 9.1019363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.2819294768
MESH:D008113 Liver Neoplasms Phenobarbital 10.2819812893 15975961 8742319 19482888 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 10.2816377806 20007298 15890375
MESH:D008113 Liver Neoplasms propiconazole 10.2819028983
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.4812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.481399818 17172636 18308698 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental propiconazole 9.4817178689
MESH:D055370 Lung Injury Lipopolysaccharides 3.8621114838
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 6.3415375486
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3415318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008654 Mesothelioma Selenium 2.7315107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3217484760
MESH:D009336 Necrosis Trinitrotoluene 4.6118551238
MESH:D009369 Neoplasms pirinixic acid 1.8817405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1519348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7518514411
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases Trinitrotoluene 4.2017852074 12819281 14694615
MESH:D010018 Osteomalacia Phenobarbital 4.2117016548
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4416965848
MESH:D010212 Papilloma Hydrogen Peroxide 3.9412065085
MESH:D010954 Plasmacytoma Selenium 4.7415087411
MESH:D011014 Pneumonia Lipopolysaccharides 4.4011605937 12224865
MESH:D011230 Precancerous Conditions Cyclosporine 8.5412371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.542563599
MESH:D019310 Pseudolymphoma Phenobarbital 4.3412752131
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D000608 Renal Aminoacidurias Mercuric Chloride 5.952918855
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6310835634
MESH:D012216 Rheumatic Diseases Auranofin 7.2817034761
MESH:D012640 Seizures Phenobarbital 5.9216876388 3137016 11442880 4039156
MESH:D012640 Seizures Trinitrotoluene 5.9218551238
MESH:D003294 Seizures, Febrile Phenobarbital 4.676407741
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 5.7312065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.738532709
MESH:D013163 Splenomegaly Trinitrotoluene 5.0515817613
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0315821434
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.941399818
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
KEGG:00240 Pyrimidine metabolism
KEGG:00450 Selenocompound metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38302
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA445876Tobacco Use Disorder
    Releated drug ID Related drug Name
    PA448687bupropion
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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