AutismKB 2.0

Annotation Detail for SMC2


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Basic Information Top
Gene Symbol:SMC2 ( CAP-E,CAPE,FLJ10093,SMC2L1,hCAP-E )
Gene Full Name: structural maintenance of chromosomes 2
Band: 9q31.1
Quick LinksEntrez ID:10592; OMIM: 605576; Uniprot ID:SMC2_HUMAN; ENSEMBL ID: ENSG00000136824; HGNC ID: 14011
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200010Aurora B signaling
No data
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Related Diseases/Disorders Top
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Desease IDDesease Name
1761Respiratory tract disease
2239Lymphoma
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SMC2 mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SMC2 proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMC2 mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of SMC2 mRNAincreases expression 16474171
D016572 Cyclosporine Cyclosporine results in decreased expression of SMC2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of SMC2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of SMC2 mRNA]decreases reaction|increases expression 17854601
D004958 Estradiol Estradiol results in increased expression of SMC2 mRNAincreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SMC2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMC2 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in increased expression of SMC2 mRNAincreases expression 16474171
D010126 Ozone Ozone results in increased expression of SMC2 mRNAincreases expression 12763052
D010634 Phenobarbital Phenobarbital affects the expression of SMC2 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of SMC2 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of SMC2 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of SMC2 mRNAincreases expression 18301758
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of SMC2 mRNA]increases expression|increases reaction 17950772
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of SMC2 mRNAincreases expression 16474171
D011374 Progesterone Progesterone results in increased expression of SMC2 mRNAincreases expression 18070364
C004648 testosterone enanthate testosterone enanthate affects the expression of SMC2 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMC2 mRNAaffects cotreatment|increases expression 17942748
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of SMC2 mRNAincreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2715322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Estradiol 7.0411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0414692618
MESH:D000230 Adenocarcinoma Genistein 7.0411473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.633712494
MESH:D000236 Adenoma Diethylnitrosamine 6.6310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 24.8217162532 17620307 18056438 19061943 16434500 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 24.8217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 24.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 24.8216835633
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6317854713 16373670
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0211289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001862 Bone Resorption bisphenol A 3.8411985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3417868700
MESH:D001930 Brain Injuries Progesterone 4.2415665606 15845082 15380490
MESH:D001943 Breast Neoplasms bisphenol A 2.9517123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9517474063
MESH:D001943 Breast Neoplasms Estradiol 2.9519861407 16675129 17289903 17261762 12948864 14630087 17018787 18497071
MESH:D001943 Breast Neoplasms Genistein 2.9517200150 16873071 16541309
MESH:D001943 Breast Neoplasms Progesterone 2.9517614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6616777450 15516495 18417511 19059883 18315731 14754758 17626835
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.367296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.3612619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.3620935162 19701751 3581430 16830150 19335982 18056438 18785209 16569478 19519916 19208518 18971187 19107877 16807293 20101231 17428255 18788625 19418558 18506893 16779866 16878318 10737359 20214788 20512989 19919837 21159647 16328049 17761372 16698587 20524982 17162532 17173139 16540662 17978847 19383236 20084675 18494052 18665156 10672840 20007298 16935385 19394651 16681979 19822196 20514400 17138121 3084413 19171122 18210153 11831363 19539802 16288022 18978308 18691550 17055752 16502159 20432363 19052882 20727157 18393292
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.3616924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.3616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.3620007298 20935162 6705139 17173139 1701930
MESH:D002278 Carcinoma in Situ bisphenol A 4.9817123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.667296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.2916332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 20.947505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.9420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.9412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 20.9417174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.9418566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.099022650 19486331
MESH:D002779 Cholestasis Cyclosporine 19.0919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 19.0917110522 16919318 17681005 15861022 16105132 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 19.0919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.098697196 12621046 16354765 15668235 15340226
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.5317936198 16782535 16867261 18200517 11698051 16474422 18023891 16804969 17991707
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4317276891
MESH:D003110 Colonic Neoplasms Genistein 2.2817182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003704 Dementia Polychlorinated Biphenyls 4.6816140633
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7918759878 12868966 11298694 2524372 8970840 8156756 11906362 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.472952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.0820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.0816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4817187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.147440962 9328219 9653073 1440618 8291058 6679447 9022650 16192314 11289319 18289764 18692083 18648102 6482804
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.1419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.9812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.9817692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.5816402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.4611473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 7.4611473722
MESH:D004715 Endometriosis Progesterone 8.8716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.8710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.093659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.873922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.013659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.373581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3720426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Cyclosporine 18.5919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 18.5921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.5915345470
MESH:D005234 Fatty Liver pirinixic acid 18.5920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D005355 Fibrosis Cyclosporine 14.7612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.7620067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 14.7617994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D005909 Glioblastoma Genistein 3.2416598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.027505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.506705139
MESH:D006529 Hepatomegaly Phenobarbital 14.3116109766
MESH:D006529 Hepatomegaly pirinixic acid 14.3119176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.3115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.7517440010
MESH:D019584 Hot Flashes Estradiol 3.7517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 16354765 15340226 16959395 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9215034207
MESH:D006973 Hypertension Cyclosporine 4.9210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9218670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3915869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Diethylnitrosamine 8.2418785209
MESH:D007249 Inflammation Progesterone 8.2415869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2412878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.5718200517
MESH:D007333 Insulin Resistance bisphenol A 12.2416393666
MESH:D007333 Insulin Resistance Estradiol 12.2416627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.2416306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.5917994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.028074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Cyclosporine 5.908314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.9015618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.266582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2612371664
MESH:D007680 Kidney Neoplasms Estradiol 12.2615610895
MESH:D007938 Leukemia Genistein 3.0118980019 17468513
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.6018407596 18665156 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 6.6021047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.189327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.9117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9112878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0917034775
MESH:D008107 Liver Diseases Phenobarbital 4.0919363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.152125692 9163691 18177683 15890375
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.1519294768 19427195 18754104 20137499 2862719 19073162 19254457 21047994 19642983 20434301 21278145 19256749 18644402 19812893 2422723 16942905 19426721 19090486 15885732 9163691 18978307 19551842 15175105 20405173 21167192 12771043 19638242 10737359 18648771 20452335 19996281 19850985 19690152 19833225 20101389 20492335 20583210 12112319 20118626 18977376 20501860 19499222 21071580 19255062
MESH:D008113 Liver Neoplasms Phenobarbital 14.158742319 19812893 19482888 19073162 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 14.1516377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.1516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 23.226587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 23.228603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 23.2217854601 16267830 18544905 19009564 18164116 19004024 19126423 16842330 2563599 19539802 18079962 21159647 3124819 17174075 17942915 19519916 18775883 18308698 18093689 9362446 18253720 18282651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 23.226150874 18308698 2563599 1399818 17172636
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 23.221423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 23.2212151625
MESH:D008171 Lung Diseases Ozone 3.368266340 19066396
MESH:D055370 Lung Injury Ozone 3.8320417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8314755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8320970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Ozone 4.837614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8319555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.9416891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.9412929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.9411408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4819453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction Genistein 5.6517141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.6519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.0816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.0817141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.673581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.673581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9417405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 23.3311399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 23.3316427766 11399458
MESH:D009421 Nervous System Malformations Genistein 23.3316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 23.3314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.906679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.404026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D010024 Osteoporosis Genistein 3.2419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0716169203
MESH:D010049 Ovarian Diseases bisphenol A 4.9811985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.8819401270
MESH:D010051 Ovarian Neoplasms Genistein 7.8819005980
MESH:D010051 Ovarian Neoplasms Progesterone 7.8817393432 16525653
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2416540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.2416965848
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.1817698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3816702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D011014 Pneumonia Ozone 4.3918007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 15.1712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 15.172563599
MESH:D011230 Precancerous Conditions Phenobarbital 15.172563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.4810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4811118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.4920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.4920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1316740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.1316740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1315256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.1315721890
MESH:D011537 Pruritus Ethinyl Estradiol 3.3015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.5012752131
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7810548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.363692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8518045962
MESH:D012640 Seizures Phenobarbital 2.684039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.2715862959 16503802
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D019966 Substance-Related Disorders bisphenol A 3.9716045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.861399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.867505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.861399818
MESH:D013978 Tibial Fractures Estradiol 4.6919048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.278074119
MESH:D014591 Uterine Diseases bisphenol A 5.0114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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