AutismKB 2.0

Annotation Detail for ERN2


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Basic Information Top
Gene Symbol:ERN2 ( IRE1b )
Gene Full Name: endoplasmic reticulum to nucleus signaling 2
Band: 16p12.2
Quick LinksEntrez ID:10595; OMIM: 604034; Uniprot ID:ERN2_HUMAN; ENSEMBL ID: ENSG00000134398; HGNC ID: 16942
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic affects the expression of ERN2 mRNAaffects expression 18414638
C017947 sodium arsenite sodium arsenite results in increased expression of ERN2 mRNAincreases expression 17350061
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.7715276417
MESH:D018246 Adrenocortical Adenoma Arsenic 17.8017306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 17.8016712894 17306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9712569548 16251483 18414634 16835338
MESH:D050197 Atherosclerosis Arsenic 3.5112928151 19371607
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.8317687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.4017306315 16507464
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.4015276417 16507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.2017687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.2018572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.5818640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.7715738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.7818022660 16973168
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.3119524636 20056578
MESH:D005534 Foot Diseases Arsenic 6.636392382
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.5716452187
MESH:D006689 Hodgkin Disease sodium arsenite 3.6212676792
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.9617050553
MESH:D006973 Hypertension Arsenic 3.0116076760 11953799 9931084
MESH:D006987 Hypesthesia Arsenic 6.6316093927
MESH:D007248 Infertility, Male sodium arsenite 3.2912646999 15346721
MESH:D007642 Keratosis Arsenic 5.8816930632 12749816
MESH:D007674 Kidney Diseases sodium arsenite 3.0420008137
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.8517339181
MESH:D008107 Liver Diseases Arsenic 2.6311134558
MESH:D008113 Liver Neoplasms Arsenic 5.2916368122
MESH:D008113 Liver Neoplasms sodium arsenite 5.2916712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.4819095001
MESH:D008175 Lung Neoplasms Arsenic 2.7617306315 19168569 17976673
MESH:D008175 Lung Neoplasms sodium arsenite 2.7617306315 17077188 16712894 15276417 19931552
MESH:D008545 Melanoma sodium arsenite 2.0816487513 19082730
MESH:D017202 Myocardial Ischemia Arsenic 4.3915371236
MESH:D009369 Neoplasms sodium arsenite 2.6911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.4320056578
MESH:D009436 Neural Tube Defects Arsenic 8.4616620997
MESH:D009436 Neural Tube Defects sodium arsenite 8.4612854658
MESH:D020078 Neurogenic Inflammation Arsenic 4.9817056641
MESH:D010051 Ovarian Neoplasms Arsenic 5.4217306315
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.4215276417 17306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.8516093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.8815371236 6392382 16905509
MESH:D011471 Prostatic Neoplasms Arsenic 3.3316140617
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3316039940
MESH:D011507 Proteinuria Arsenic 4.6121343184
MESH:D012871 Skin Diseases Arsenic 2.8418709164 19834688 6392382 15952646 17453740 17050553 17548696 16353154 16702368 16759981 17938729
MESH:D012878 Skin Neoplasms Arsenic 6.5817029826 15504454 17976673 19538983 16251483 17050553
MESH:D012878 Skin Neoplasms sodium arsenite 6.5819524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1812854658
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.7911144890 19429237 17976673 17306315 19322015 15987713 18640142
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.7916452187 17306315 11723127 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.2711813266
MESH:D014652 Vascular Diseases Arsenic 15.0317056641
MESH:D014652 Vascular Diseases sodium arsenite 15.0317056641
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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