AutismKB 2.0

Annotation Detail for SLCO1B1


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Basic Information Top
Gene Symbol:SLCO1B1 ( LST-1,LST1,MGC133282,OATP-C,OATP1B1,OATP2,OATPC,SLC21A6 )
Gene Full Name: solute carrier organic anion transporter family, member 1B1
Band: 12p12.1
Quick LinksEntrez ID:10599; OMIM: 604843; Uniprot ID:SO1B1_HUMAN; ENSEMBL ID: ENSG00000134538; HGNC ID: 10959
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500831Recycling of bile acids and salts
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1982Myopathy
2197Metabolism disease
Desease Name
HEMATOLOGICAL
cholesterol
irinotecan pharmacokinetics
nateglinide pharmacokinetics
serum bilirubin levels
simvastatin pharmacokinetics
altered OATP-C transport activity
cholesterol, HDL cholesterol, LDL heart transplant
Muscular Diseases
PHARMACOGENOMIC
atrasentan phamacokinetics
cholesterol synthesis rate
rosuvastatin pharmacokinetics
METABOLIC
lathosterol
cholesterol cholesterol, HDL cholesterol, LDL triglycerides
response to statin therapy
Desease Name
Response to statin therapy
Serum bilirubin levels
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLCO1B1 proteinaffects expression 20106945
C065179 atorvastatin atorvastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]decreases reaction|increases transport 15616150
C065179 atorvastatin atorvastatin results in decreased activity of SLCO1B1 proteindecreases activity 15616150
D001647 Bile Acids and Salts SLCO1B1 protein affects the transport of Bile Acids and Saltsaffects transport 15841457
D001647 Bile Acids and Salts SLCO1B1 protein affects the uptake of Bile Acids and Saltsaffects uptake 15841457
D001663 Bilirubin Bilirubin results in increased expression of SLCO1B1 mRNAincreases expression 15382119
D001663 Bilirubin IL1B protein inhibits the reaction [Bilirubin results in increased expression of SLCO1B1 mRNA]decreases reaction|increases expression 15382119
D002220 Carbamazepine Carbamazepine results in increased expression of SLCO1B1 mRNAincreases expression 17112801
D003010 Clorgyline Clorgyline results in increased expression of SLCO1B1 mRNAincreases expression 19691856
D016572 Cyclosporine Cyclosporine results in decreased expression of SLCO1B1 mRNAdecreases expression 20106945
C025483 estradiol-17 beta-glucuronide atorvastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]decreases reaction|increases transport 15616150
C025483 estradiol-17 beta-glucuronide Lovastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]decreases reaction|increases transport 15616150
C025483 estradiol-17 beta-glucuronide PKI 166 inhibits the reaction [SLCO1B1 protein affects the transport of estradiol-17 beta-glucuronide]affects transport|decreases reaction 15280219
C025483 estradiol-17 beta-glucuronide rifamycin SV inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]decreases reaction|increases transport 15616150
C025483 estradiol-17 beta-glucuronide Simvastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]decreases reaction|increases transport 15616150
C025483 estradiol-17 beta-glucuronide SLCO1B1 protein affects the uptake of estradiol-17 beta-glucuronideaffects uptake 15652233
C025483 estradiol-17 beta-glucuronide [SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronideaffects cotreatment|increases uptake 18180276
C025483 estradiol-17 beta-glucuronide SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronideincreases transport 15616150
C017296 estrone sulfate SLCO1B1 protein affects the uptake of estrone sulfateaffects uptake 15652233
C093230 fexofenadine [SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of fexofenadineaffects cotreatment|increases uptake 18180276
C093230 fexofenadine SLCO1B1 protein results in increased uptake of fexofenadineincreases uptake 18245269
C065180 fluvastatin SLCO1B1 protein affects the import of fluvastatinaffects import 16046661
D008148 Lovastatin Lovastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]decreases reaction|increases transport 15616150
D008148 Lovastatin Lovastatin results in decreased activity of SLCO1B1 proteindecreases activity 15616150
C033457 phenobarbital quinidine IL1B protein inhibits the reaction [phenobarbital quinidine results in increased expression of SLCO1B1 mRNA]decreases reaction|increases expression 15382119
C033457 phenobarbital quinidine phenobarbital quinidine results in increased expression of SLCO1B1 mRNAincreases expression 15382119
C108475 pitavastatin SLCO1B1 protein affects the transport of pitavastatinaffects transport 15955871
C410026 PKI 166 PKI 166 inhibits the reaction [SLCO1B1 protein affects the transport of estradiol-17 beta-glucuronide]affects transport|decreases reaction 15280219
C410026 PKI 166 PKI 166 results in decreased activity of SLCO1B1 proteindecreases activity 15280219
C410026 PKI 166 SLCO1B1 protein affects the transport of PKI 166 metaboliteaffects transport 15280219
C072379 repaglinide SLCO1B1 gene SNP affects the metabolism of repaglinideaffects metabolic processing 15961978
D012293 Rifampin Rifampin results in increased expression of SLCO1B1 mRNAincreases expression 15670600
16837569
D012293 Rifampin SLCO1B1 protein affects the uptake of Rifampinaffects uptake 15652233
C023808 rifamycin SV rifamycin SV inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]decreases reaction|increases transport 15616150
C023808 rifamycin SV rifamycin SV results in decreased activity of SLCO1B1 proteindecreases activity 15616150
D019821 Simvastatin Simvastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]decreases reaction|increases transport 15616150
D019821 Simvastatin Simvastatin results in decreased activity of SLCO1B1 proteindecreases activity 15616150
D013448 Sulfobromophthalein SLCO1B1 protein affects the import of Sulfobromophthaleinaffects import 16046661
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 4.468986270
OMIM:607154 ALLERGIC RHINITIS fexofenadine 5.6816037679
MESH:D001714 Bipolar Disorder Carbamazepine 4.0917594078 20046352
MESH:D001943 Breast Neoplasms estrone sulfate 4.5217261762
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9521507988 12619106 12907637
MESH:D006332 Cardiomegaly atorvastatin 4.3818360054
MESH:D002386 Cataract Simvastatin 4.5812518039
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.4712371664
MESH:D002779 Cholestasis Cyclosporine 8.5419486331
MESH:D002779 Cholestasis estradiol-17 beta-glucuronide 8.5412893835
MESH:D003324 Coronary Artery Disease atorvastatin 4.1116368305
MESH:D003327 Coronary Disease fluvastatin 4.7516142594
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.959014606
MESH:D003550 Cystic Fibrosis Simvastatin 4.8619747007
MESH:D003876 Dermatitis, Atopic fexofenadine 4.7317133778
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.3611748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3516538176 20216337 16538175 15057820
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 3.2117465707
MESH:D004362 Drug Toxicity Carbamazepine 4.3920216337
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.6517654737
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.1719915237 18855540 16538176 16415921 20485159
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.1217275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.8917116037 16628512 15008574
MESH:D004827 Epilepsy Carbamazepine 3.95821787 17178248 19439326 20417680 19700373 17465707 7988514 9014606 19620853 18234410
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.277750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.043659116 15276670
MESH:D004916 Erythromelalgia Carbamazepine 5.6419549232
MESH:D004942 Esophagitis, Peptic Bile Acids and Salts 6.4711346197
MESH:D005076 Exanthema Carbamazepine 5.3820485159
MESH:D005234 Fatty Liver Cyclosporine 2.7719224547
MESH:D005355 Fibrosis Cyclosporine 3.0612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D006333 Heart Failure atorvastatin 8.2116360360
MESH:D006333 Heart Failure pitavastatin 8.2115502390
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006937 Hypercholesterolemia atorvastatin 4.9911583720
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.6510459572
MESH:D006938 Hyperlipoproteinemia Type II atorvastatin 10.1816238680
MESH:D006938 Hyperlipoproteinemia Type II Simvastatin 10.1816238680
MESH:D006965 Hyperplasia Carbamazepine 5.1218773962
MESH:D006967 Hypersensitivity fexofenadine 5.2517910814
MESH:D006973 Hypertension atorvastatin 5.5917042910
MESH:D006973 Hypertension Cyclosporine 5.5910903974
MESH:D007249 Inflammation atorvastatin 3.8716908763
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.298314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6612371664
MESH:D008106 Liver Cirrhosis, Experimental atorvastatin 3.2917347453
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.3215890375 9163691 18177683 2125692
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.698603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8714755239
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 6.0411422169
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 6.0716628512
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 6.0711422169
MESH:D008607 Mental Retardation Carbamazepine 3.709014606
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D009101 Multiple Myeloma fluvastatin 4.4616996129
MESH:D009135 Muscular Diseases atorvastatin 5.3816239165
MESH:D009164 Mycobacterium Infections Rifampin 5.4718474467
MESH:D009224 Myotonia Congenita Carbamazepine 5.3820399394
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome atorvastatin 9.4619348381
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.4619348381 18481113
MESH:D009421 Nervous System Malformations Carbamazepine 4.8216990009
MESH:D010018 Osteomalacia Carbamazepine 5.3817016548
MESH:D010146 Pain Carbamazepine 3.9615215642
MESH:D010267 Parapsoriasis Carbamazepine 5.6116538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.8417145499 17679678
MESH:D011085 Polycystic Ovary Syndrome Simvastatin 5.2717105841
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011248 Pregnancy Complications Carbamazepine 5.069014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 4.809014606
MESH:D011471 Prostatic Neoplasms Clorgyline 4.3119691856
MESH:D011537 Pruritus fexofenadine 5.5317133778
MESH:D019310 Pseudolymphoma Carbamazepine 5.529591791 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D012640 Seizures Carbamazepine 3.7416876388 19414003 9844417 15946322 9046859 16938433 16180713
MESH:D012893 Sleep Disorders Carbamazepine 5.0419414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.1220485159 15057820 16415921 16538176 19694795 19915237 18855540
MESH:D014376 Tuberculosis Rifampin 4.7115236969 18397238
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
KEGG:04976 Bile secretion
REACT:22258 Metabolism of lipids and lipoproteins
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134865839
    • Releated gene ID Related gene Name
    PA134865839SLCO1B1
    Releated disease ID Related disease Name
    PA445062Neoplasms
    PA445019Myocardial Infarction
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443937Drug Toxicity
    PA443899Diarrhea
    PA445113Neutropenia
    PA443796Coronary Artery Disease
    PA443450Asthma
    PA444997Muscular Diseases
    PA445208Pain
    PA157379134Myalgia unspecified
    PA447048Myopathy, Central Core
    PA444516Hypercholesterolemia
    PA128407009Mycobacterium Infections
    PA443636Carotid Artery Diseases
    PA445549Rhabdomyolysis
    PA447048Myopathy, Central Core
    PA443886Diabetes Mellitus
    PA446108Colorectal Neoplasms
    PA445046Nasopharyngeal Neoplasms
    PA443622Carcinoma, Non-Small-Cell Lung
    PA443340Anemia
    PA444773Leukopenia
    PA445062Neoplasms
    PA445846Thrombocytopenia
    PA446975Neurotoxicity Syndromes
    Releated drug ID Related drug Name
    PA448486arsenic trioxide
    PA164778866liothyronine
    PA450842penicillin g
    PA165110775SN-38
    PA151070295thyroxine
    PA450566mycophenolate mofetil
    PA451365sirolimus
    PA450496midazolam
    PA449782glibenclamide
    PA449057clotrimazole
    PA450500mifepristone
    PA450761paclitaxel
    PA451799troglitazone
    PA451848valsartan
    PA451619terfenadine
    PA164743013caspofungin
    PA449345dinoprostone
    PA450970pioglitazone
    PA164742950olmesartan
    PA450428methotrexate
    PA449456enalapril
    PA450546montelukast
    PA133950441hmg coa reductase inhibitors
    PA449088codeine
    PA450550morphine
    PA450600nateglinide
    PA451283rosiglitazone
    PA449789glycine
    PA449319digoxin
    PA450264lopinavir
    PA451363simvastatin
    PA448500atorvastatin
    PA448897cerivastatin
    PA449167cyclosporine
    PA449334diltiazem
    PA449750gemfibrozil
    PA450132itraconazole
    PA450272lovastatin
    PA451260ritonavir
    PA451868verapamil
    PA449503estradiol
    PA10034bosentan
    PA449621fexofenadine
    PA151958355grapefruit juice
    PA10005adefovir dipivoxil
    PA449001cimetidine
    PA450085irinotecan
    PA451234repaglinide
    PA134308647rosuvastatin
    PA142650384pitavastatin
    PA143414738atrasentan
    PA10816ezetimibe
    PA451250rifampin
    PA449688fluvastatin
    PA451089pravastatin
    PA451578tacrolimus
    PA450146ketoconazole
    PA450494miconazole
    PA449014cisplatin
    Drug Bank Top
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00091 inhibitor Cyclosporine Antirheumatic Agents;Immunomodulatory Agents;Enzyme Inhibitors;Dermatologic Agents;Immunosuppressive Agents;Antifungal Agents
    DB00175 inhibitor Pravastatin Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00177 substrate Valsartan Antihypertensive Agents;Angiotensin II Receptor Antagonists
    DB00197 inhibitor Troglitazone Antineoplastic Agents;Hypoglycemic Agents;Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00213 inhibitor Pantoprazole Anti-Ulcer Agents;Proton-pump Inhibitors
    DB00220 inhibitor Nelfinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB00224 inhibitor Indinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB00227 inhibitor Lovastatin Antineoplastic Agents;Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00275 substrate Olmesartan Antihypertensive Agents;Angiotensin II Type 1 Receptor Blockers
    DB00279 substrate Thyrolar Hormone Replacement Agents
    DB00286 inhibitor Prempro Estrogens
    DB00345 inhibitor Aminohippurate Diagnostic aids;Indicators and Reagents
    DB00390 inhibitor Digoxin Enzyme Inhibitors;Antiarrhythmic Agents;Cardiotonic Agents;Anti-Arrhythmia Agents
    DB00412 inhibitor Avandaryl Hypoglycemic Agents;Vasodilator Agents;Fibrinolytic Agents;Thazolidinediones
    DB00439 substrate Cerivastatin Anticholesteremic Agents;Antilipemic Agents;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00503 inhibitor Kaletra Anti-HIV Agents;HIV Protease Inhibitors
    DB00520 inhibitor Caspofungin Antifungals;Antifungal Agents
    DB00563 substrate Methotrexate Antineoplastic Agents;Antirheumatic Agents;Antimetabolites;Enzyme Inhibitors;Folic Acid Antagonists;Dermatologic Agents;Immunosuppressive Agents;Nucleic Acid Synthesis Inhibitors;Abortifacient Agents, Nonsteroidal;Abortifacient Agents;Antimetabolites, Antineoplastic
    DB00583 inhibitor L-Carnitine Vitamins (Vitamin B Complex);Nootropic Agents;Metabolite;Nutraceutical;Vitamin B Complex
    DB00641 inhibitor Vytorin Anticholesteremic Agents;Antilipemic Agents;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00655 inhibitor Holis 98 Antineoplastic Agents;Estrogens;Osteoporosis Prophylactic;Anti-menopausal Agents
    DB00661 inhibitor Tarka Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    DB00669 substrate Sumatriptan Vasoconstrictor Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00762 inhibitor Irinotecan Antineoplastic Agents;Radiation-Sensitizing Agents;Parasympathomimetics;Enzyme Inhibitors;Prodrugs;Antineoplastic Agents, Phytogenic
    DB00783 inhibitor Triquilar 21 Anticholesteremic Agents;Estrogens;Anti-menopausal Agents
    DB00859 substrate Penicillamine Antirheumatic Agents;Chelating Agents;Antidotes
    DB00877 inhibitor Sirolimus Anti-Bacterial Agents;Antifungals;Immunosuppressive Agents;Antifungal Agents;Antibiotics, Antineoplastic;Macrolides
    DB00908 inhibitor Quinidine Enzyme Inhibitors;Antiarrhythmic Agents;Antimalarials;Muscarinic Antagonists;Adrenergic alpha-Antagonists;Anti-Arrhythmia Agents
    DB00917 substrate Dinoprostone Oxytocics;Prostaglandins
    DB01045 inhibitor Rifater Enzyme Inhibitors;Antituberculosis Agents;Nucleic Acid Synthesis Inhibitors;Leprostatic Agents;Antibiotics;Antibiotics, Antitubercular
    DB01053 substrate Penicillin G Anti-Bacterial Agents;Penicillins
    DB01076 inhibitor Caduet Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB01092 substrate Ouabain Enzyme Inhibitors;Cardiotonic Agents
    DB01132 inhibitor ActoplusMet Hypoglycemic Agents;Thazolidinediones
    DB01232 inhibitor Saquinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB01241 inhibitor Gemfibrozil Antilipemic Agents;Fribic Acid Derivatives
    DB01393 inhibitor Hepaconda Antilipemic Agents
    DB01583 substrate Liotrix Hormone Replacement Agents
    DB01892 inhibitor Hyperforin
    DB02659 inducer Cholic Acid
    DB04348 inducer Taurocholic Acid Cholagogues and Choleretics;Detergents
    DB06151 inhibitor Acetylcysteine Antiviral Agents;Free Radical Scavengers;Expectorants
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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