AutismKB 2.0

Annotation Detail for CENPC1


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Basic Information Top
Gene Symbol:CENPC1 ( CENP-C,CENPC,MIF2,hcp-4 )
Gene Full Name: centromere protein C 1
Band: 4q13.2
Quick LinksEntrez ID:1060; OMIM: 117141; Uniprot ID:CENPC_HUMAN; ENSEMBL ID: ENSG00000145241; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
multiple sclerosis (severity)
IMMUNE
Desease Name
Multiple sclerosis (severity)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of CENPC1 mRNAincreases expression 20406850
C006632 arsenic trioxide arsenic trioxide results in increased expression of CENPC1 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CENPC1 mRNAaffects expression 20382639
D003010 Clorgyline Clorgyline results in increased expression of CENPC1 mRNAincreases expression 19691856
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CENPC1 mRNAdecreases expression 17557909
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of CENPC1 mRNAdecreases expression 17616710
C006253 pirinixic acid pirinixic acid results in decreased expression of CENPC1 mRNAdecreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4819825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.9616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9619483382
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1316705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1315553829 11135700 14691202 15073043 16217749
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.266135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4217110522 16919318 15861022 16105132 17333356 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.7220423518
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0318551238 21346803
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6612903497
MESH:D005234 Fatty Liver arsenic trioxide 14.7615073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7615345470
MESH:D005234 Fatty Liver pirinixic acid 14.7619236843 20131406
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 18467677 19772884 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2116705839
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1717050201 20471514 16467208 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3817217047 19642359 16966277 19035177 12018890 17107899 11161223 16112521 15748426 11468182 16331271 19075265 15336539 17712046 16330433 15622746 19225113 12679006 16823087 15213294 16891316 12712474 17869043 9834237 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.937678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9314682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.9320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.502876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5020377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2911468182 19417148 19549372 14977855 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.6019131511
MESH:D011471 Prostatic Neoplasms Clorgyline 3.6019691856
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.3415864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3912845720 12973940 20435036 11780464
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26398
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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