Annotation Detail for SH2B2
Basic Information Top
| Gene Symbol: | SH2B2 ( APS ) |
|---|---|
| Gene Full Name: | SH2B adaptor protein 2 |
| Band: | 7q22.1 |
| Quick Links | Entrez ID:10603; OMIM: 605300; Uniprot ID:SH2B2_HUMAN; ENSEMBL ID: ENSG00000160999; HGNC ID: 17381 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| No data |
| No data |
| No data |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C061133 | Am 80 | Am 80 results in increased expression of SH2B2 mRNA | increases expression | 17229644 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of SH2B2 mRNA | affects expression | 16483693 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of SH2B2 mRNA | decreases expression | 18042831 |
| C041786 | palm oil | palm oil results in decreased expression of SH2B2 mRNA | decreases expression | 18042831 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 4.19 | 18287403 | |
| MESH:D001161 | Arteriosclerosis | Dietary Fats | 4.45 | 15238619 | |
| MESH:D001172 | Arthritis, Rheumatoid | Am 80 | 3.82 | 16819260 | |
| MESH:D050197 | Atherosclerosis | Am 80 | 4.55 | 16484594 | |
| MESH:D001943 | Breast Neoplasms | Dietary Fats | 2.24 | 20435547 | |
| MESH:D050171 | Dyslipidemias | Dietary Fats | 3.73 | 18367378 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Am 80 | 5.59 | 16819260 | |
| MESH:D005234 | Fatty Liver | Dietary Fats | 3.66 | 18296743 17967931 19551842 19004024 | |
| MESH:D005355 | Fibrosis | Dietary Fats | 4.08 | 18296743 | |
| MESH:D006937 | Hypercholesterolemia | Dietary Fats | 4.02 | 21332399 | |
| MESH:D006949 | Hyperlipidemias | Dietary Fats | 4.08 | 21332399 | |
| MESH:D007249 | Inflammation | Dietary Fats | 2.60 | 20412841 | |
| MESH:D007333 | Insulin Resistance | Dietary Fats | 3.34 | 11836018 18457598 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Am 80 | 4.88 | 16531727 16819260 | |
| MESH:D008103 | Liver Cirrhosis | Dietary Fats | 3.07 | 18296743 | |
| MESH:D009101 | Multiple Myeloma | Am 80 | 4.81 | 17229644 | |
| MESH:D009765 | Obesity | Dietary Fats | 2.36 | 17217161 19632207 11836018 18457598 20132043 16723640 21332399 18674790 20518802 | |
| MESH:D011471 | Prostatic Neoplasms | Am 80 | 4.64 | 16289102 | |
| MESH:D011565 | Psoriasis | Am 80 | 4.19 | 16819260 | |
| MESH:D015430 | Weight Gain | Dietary Fats | 4.11 | 16723640 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:604 | Hemostasis |
| KEGG:04910 | Insulin signaling pathway |
| KEGG:04722 | Neurotrophin signaling pathway |
Drug Bank