AutismKB 2.0

Annotation Detail for SH2B2


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Basic Information Top
Gene Symbol:SH2B2 ( APS )
Gene Full Name: SH2B adaptor protein 2
Band: 7q22.1
Quick LinksEntrez ID:10603; OMIM: 605300; Uniprot ID:SH2B2_HUMAN; ENSEMBL ID: ENSG00000160999; HGNC ID: 17381
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04722Neurotrophin signaling pathway
No data
Pathway IDPathway Name
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200012Insulin Pathway
200127PDGFR-beta signaling pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C061133 Am 80 Am 80 results in increased expression of SH2B2 mRNAincreases expression 17229644
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SH2B2 mRNAaffects expression 16483693
D004041 Dietary Fats Dietary Fats results in decreased expression of SH2B2 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of SH2B2 mRNAdecreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D001161 Arteriosclerosis Dietary Fats 4.4515238619
MESH:D001172 Arthritis, Rheumatoid Am 80 3.8216819260
MESH:D050197 Atherosclerosis Am 80 4.5516484594
MESH:D001943 Breast Neoplasms Dietary Fats 2.2420435547
MESH:D050171 Dyslipidemias Dietary Fats 3.7318367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 5.5916819260
MESH:D005234 Fatty Liver Dietary Fats 3.6618296743 17967931 19551842 19004024
MESH:D005355 Fibrosis Dietary Fats 4.0818296743
MESH:D006937 Hypercholesterolemia Dietary Fats 4.0221332399
MESH:D006949 Hyperlipidemias Dietary Fats 4.0821332399
MESH:D007249 Inflammation Dietary Fats 2.6020412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3411836018 18457598
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 4.8816531727 16819260
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0718296743
MESH:D009101 Multiple Myeloma Am 80 4.8117229644
MESH:D009765 Obesity Dietary Fats 2.3617217161 19632207 11836018 18457598 20132043 16723640 21332399 18674790 20518802
MESH:D011471 Prostatic Neoplasms Am 80 4.6416289102
MESH:D011565 Psoriasis Am 80 4.1916819260
MESH:D015430 Weight Gain Dietary Fats 4.1116723640
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04910 Insulin signaling pathway
KEGG:04722 Neurotrophin signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA145148106
  • No data
    No data
    Releated drug ID Related drug Name
    PA10804imatinib
    Drug Bank Top

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    Syndromic Genes

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018