AutismKB 2.0

Annotation Detail for MXD4


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Basic Information Top
Gene Symbol:MXD4 ( MAD4,MST149,MSTP149,bHLHc12 )
Gene Full Name: MAX dimerization protein 4
Band: 4p16.3
Quick LinksEntrez ID:10608; OMIM: NA; Uniprot ID:MAD4_HUMAN; ENSEMBL ID: ENSG00000123933; HGNC ID: 13906
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MXD4 mRNAdecreases expression 18648102
C006780 bisphenol A bisphenol A results in decreased expression of MXD4 mRNAdecreases expression 16474171
C006780 bisphenol A bisphenol A results in increased expression of MXD4 mRNAincreases expression 20678512
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MXD4 mRNAaffects expression 17484886
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of MXD4 mRNAdecreases expression 15171707
D004958 Estradiol Estradiol results in decreased expression of MXD4 mRNAdecreases expression 16474171
D004958 Estradiol Estradiol affects the expression of MXD4 mRNAaffects expression 15598610
D004958 Estradiol Estradiol results in decreased expression of MXD4 mRNAdecreases expression 14664709
D019833 Genistein Genistein results in decreased expression of MXD4 mRNAdecreases expression 16474171
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in decreased expression of MXD4 mRNAdecreases expression 16474171
C004648 testosterone enanthate testosterone enanthate affects the expression of MXD4 mRNAaffects expression 17440010
C025643 vinclozolin vinclozolin affects the expression of MXD4 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 4.6111473722
MESH:D000230 Adenocarcinoma Genistein 4.6111473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D000686 Amyloidosis Diethylstilbestrol 4.7215469931
MESH:D001008 Anxiety Disorders vinclozolin 3.8019015723
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001862 Bone Resorption bisphenol A 4.0711985600
MESH:D001943 Breast Neoplasms bisphenol A 2.0217123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0215324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 2.0218497071 12948864 14630087 17289903 19861407 17261762 17018787 16675129
MESH:D001943 Breast Neoplasms Genistein 2.0216873071 17200150 16541309
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0416227642 3786805 15700767 16192424 15721981 16124888 15673190 16011737 16050911 10355542 18705752 16097048
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.197296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.1918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 9.1915948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.1916924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.1916924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.2717123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002318 Cardiovascular Diseases Genistein 3.4416332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.127505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1218566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3019486331 9022650
MESH:D003110 Colonic Neoplasms Genistein 2.3117182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D003456 Cryptorchidism Diethylstilbestrol 12.1812952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 12.1814966744
MESH:D003704 Dementia Polychlorinated Biphenyls 4.9116140633
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0611298694 8156756 12868966 18759878 11906362 2524372 14531868 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5216647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.0518289764 9653073 18692083 18648102 11289319 6679447 6482804 7440962 9022650 16192314 9328219 1440618 8291058
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0515027814 15998439 10092053 21278145 7179309 2869522 3732212 3786805 11566570 7440962 6884620 6623471 19336974 9327722 10915739 19085960 15968718 4309450 16177239 7120509 17522070 16227642
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.8616402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.8616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 13.2716804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 13.2719148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 13.2711473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.3717595544 16045604 12795759 19224547 12631006 16239168 15959796 61145
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7715751030 16513791 16534752 16611131 16002989
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7118705752
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6216417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.2316452187
MESH:D005909 Glioblastoma Genistein 3.3816598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.036705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.0319900420 19110552
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 11.7115034207
MESH:D006965 Hyperplasia Diethylstilbestrol 11.7114722030 12960047
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007021 Hypospadias Diethylstilbestrol 4.8416002989
MESH:D007246 Infertility Diethylstilbestrol 4.5915036965
MESH:D007248 Infertility, Male vinclozolin 3.1716467254
MESH:D007333 Insulin Resistance bisphenol A 7.8616393666
MESH:D007333 Insulin Resistance Estradiol 7.8616393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007674 Kidney Diseases Estradiol 2.6915618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.496582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 13.4916762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 13.4915610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.3217184923
MESH:D007938 Leukemia Genistein 3.1117468513 18980019
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0216417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9116221502 17157831 11408273 17174718 16943688 21278145 17334410 11903743 16239168
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6518418968 17922224 14716833 15925388 18263696 11481614 12741479 15730626 18187930 12546737 15123356 18395914 18429990 17805973 18317297 17557913 18339082 17823541 18156304 15818738 15650968 18277467 15893842 17708605 16027843 14748882 17714472 17944888 12445421 12898905 17640975 12632514 17565644 18412020 15876570 17900296 18395095 17481882 12586293 17761835 12609069 16136751 16192424 15931870 17525996 16015684 18376398 17698563 12667390 18705752 12958196 18481824 16011737 18472094 18420326 15370692 17976157 12445418 15362042 20821823 18205269 14620537 13678700 18054572 12632512 16033810 16116963 18006644 17766677 18166357 10355542 12649538 15052691 16248980 15959796 16638106 17721639 12666154 15996030 15338365 18279442 15673190 18251166 14512876 17631135 18472332 16097048 12389079 14716496 15057751 18210741 17869086 14724832
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.6517823541
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215720792 16964402 15830285 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8814706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.9619294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.9615890375 16712894
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.701399818 6587162 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.7015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 10.701423854
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.4315166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.8316002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5016891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.5014578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D009203 Myocardial Infarction Genistein 2.9317141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.0416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.0417141266
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms Diethylstilbestrol 2.8515313581
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations bisphenol A 25.6011399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 25.6011399458
MESH:D009421 Nervous System Malformations Estradiol 25.6011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 25.6016427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.616482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010024 Osteoporosis Genistein 3.3719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3116169203
MESH:D010049 Ovarian Diseases bisphenol A 5.2711985600
MESH:D010051 Ovarian Neoplasms Estradiol 5.0819401270
MESH:D010051 Ovarian Neoplasms Genistein 5.0819005980
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4516702228
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.4914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.9315687265 16977796
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 18.1310548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 18.1317184923
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 18.1318220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.2520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.2520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8817136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.8815721890
MESH:D011472 Prostatitis vinclozolin 5.2218629315
MESH:D011629 Puberty, Precocious bisphenol A 5.0710548101
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D013088 Spermatocele Diethylstilbestrol 5.0316002989 16709447
MESH:D019966 Substance-Related Disorders bisphenol A 4.2716045194 16684133
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.047505956 1399818 3712494 6587162 6582329
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.428074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.4217306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.2316175088
MESH:D014591 Uterine Diseases bisphenol A 14.9014652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 14.9014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.3116690809 15809267
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6916002989 16513791
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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