AutismKB 2.0

Annotation Detail for PDLIM5


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Basic Information Top
Gene Symbol:PDLIM5 ( ENH,ENH1,LIM )
Gene Full Name: PDZ and LIM domain 5
Band: 4q22.3
Quick LinksEntrez ID:10611; OMIM: 605904; Uniprot ID:PDLI5_HUMAN; ENSEMBL ID: ENSG00000163110; HGNC ID: 17468
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1907Depression
1934Cancer
2045Bipolar disorder
2198Psychotic disorder
2221Behavior disease
Desease Name
prostate cancer
CANCER
PSYCH
schizophrenia
Desease Name
Prostate cancer
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PDLIM5 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PDLIM5 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of PDLIM5 mRNAdecreases expression 20406850
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PDLIM5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PDLIM5 mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine results in decreased expression of PDLIM5 mRNAdecreases expression 16084531
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PDLIM5 mRNAdecreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PDLIM5 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDLIM5 mRNAdecreases expression 19150397
20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PDLIM5 mRNAaffects expression 17484886
D003345 Corticosterone Corticosterone results in increased expression of PDLIM5 mRNAincreases expression 15755911
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of PDLIM5 mRNAdecreases expression 16084531
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PDLIM5 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of PDLIM5 mRNAincreases expression 19619570
D005419 Flavonoids Flavonoids results in increased expression of PDLIM5 mRNAincreases expression 18035473
D005472 Fluorouracil PDLIM5 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C051890 irinotecan irinotecan analog results in decreased expression of PDLIM5 mRNAdecreases expression 18927307
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of PDLIM5 mRNAdecreases expression 20713471
C080955 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of PDLIM5 mRNAincreases expression 11494140
C006253 pirinixic acid pirinixic acid results in decreased expression of PDLIM5 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of PDLIM5 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PDLIM5 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PDLIM5 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PDLIM5 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.207525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2011752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 10.0011798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.0020464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 10.0011473722
MESH:D000230 Adenocarcinoma Fluorouracil 10.0017638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.706695378
MESH:D000236 Adenoma Methylcholanthrene 6.7010545420 6695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.6216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.6216835633
MESH:D000740 Anemia Fluorouracil 8.4215504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4211748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001249 Asthma epigallocatechin gallate 3.3616516891
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4011922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.9819761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.8016206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.8019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3117474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 2.3117261762 12948864 18497071 17289903 16675129 19861407 17018787 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 2.3116595493 18608205 15136595 18357371 19217205 16110121 16557594
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.3117474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3120435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2411589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6916124888 15700767 10355542 15673190 16192424 15721981 3786805 16227642 18705752 16050911 16011737 16097048
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5916051944
MESH:D002277 Carcinoma Fluorouracil 13.5717121937
MESH:D002277 Carcinoma Methylcholanthrene 13.5710545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.5716835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.8816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.8816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.883084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.8815553829 11135700 16217749 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.8818788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.8816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.8817971768 17045692 17088986 18930000 16799960 16332177
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7919014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9818695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0412490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 7.5117015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.5120419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.5116757204 17066447 18986760 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3216120746 18670907 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.2514694615
MESH:D002386 Cataract Acetaminophen 7.2510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 20.476135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.4720889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 20.4718226522
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.4718566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 20.4716192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis pirinixic acid 2.7619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0715340226 8697196 15668235 16354765 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9117169374 16510598 17725105 15001691 16340194 17172411 17018589 17287894 17016597 18772588
MESH:D003110 Colonic Neoplasms irinotecan 3.9117725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.4620501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4614970324 17401013 15289873 18509181 18448328 16282729 20501625 16524972 17255274 17016601 18802399 16331619 16391804 18288408 17695437 17094418 18383874 17594712 16303861 17454858 18949393 15148649
MESH:D015179 Colorectal Neoplasms irinotecan 3.4616303861 17159606 16391804 18509181 17454858 18259882 15273666
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.9315095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.9314669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4410048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.6018551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.6018551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.3019747007
MESH:D007644 Darier Disease Fluorouracil 4.7116733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0115213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 4.5516988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3319279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 18.3021346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.3011739529 16177239 16485898 10915739 15968718 14986274 12594235 12153990 16393943 11287661 17522070 19085960 19370779 16081117 19164858 14550746 12392966 19416960 2444490 17906064 17562736 18071297 19923254 11834606 18713872 16227642 11743745 14725611 10774834 16781746 11421492 12540782 19420014 11529661 15619225 16109766 10663392 12958197 19739265 12705907 11461765
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 18.3011287661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 18.3021278145 15027814 4309450 11566570 16227642 10092053 15998439 19336974 3786805 2869522 17522070 3732212 10915739 7179309 16177239 6884620 7440962 6623471 15968718 19085960 9327722 7120509
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.3020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D004487 Edema pirinixic acid 6.2712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8218230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 2.9219148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.949294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.2120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.2112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.2116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.2115173087 16481741 16337965 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver arsenic trioxide 12.6315073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.6312795759 61145 17595544 12631006 15959796 19224547 16239168 16045604
MESH:D005234 Fatty Liver pirinixic acid 12.6320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8510962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 8.3118705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1816904648
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3315102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5119110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.9718467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D007249 Inflammation Flavonoids 4.8417296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8412200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.0016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.0016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007674 Kidney Diseases Acetaminophen 5.7215629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.7215618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.1616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.1616705839
MESH:D007680 Kidney Neoplasms Estradiol 17.1615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 17.1616985049
MESH:D007938 Leukemia arsenic trioxide 2.7915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7112560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6819077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1220471514 16467208 17050201 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1617649720 17712046 9834237 15748426 19225113 17107899 16966277 15622746 16112521 17217047 19035177 12712474 15213294 12679006 11468182 11161223 19075265 16331271 19642359 12018890 16891316 15336539 16823087 17869043 16330433
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2716882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7617174718 11408273 11903743 16221502 17334410 16943688 21278145 16239168 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.6217900296 12445418 10355542 15818738 17721639 15893842 16011737 17565644 15123356 17481882 18263696 15730626 14724832 16116963 14716833 18006644 16027843 12546737 15057751 17761835 18705752 17823541 17944888 16136751 17766677 12666154 15959796 14748882 18429990 12649538 15876570 18210741 18156304 15052691 17525996 17698563 12632512 17557913 17976157 14620537 17714472 12389079 12667390 15650968 18376398 18395914 16097048 18054572 12445421 15338365 17640975 18472332 18420326 14716496 15996030 12898905 15362042 16638106 17708605 16015684 12609069 16248980 18395095 17869086 18187930 12632514 16033810 15673190 18481824 15931870 18251166 18277467 12586293 17805973 18205269 18472094 13678700 15370692 18166357 18317297 11481614 15925388 17631135 14512876 20821823 18412020 18418968 17922224 18339082 12741479 12958196 18279442 16192424
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 6.6217481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6212878042
MESH:D008107 Liver Diseases Acetaminophen 3.8219014921 12587719 19460945 16610002 12969438 11587558 19784758 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.8215720792 17285989 16246199 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.1417185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.1416899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.417678174
MESH:D008113 Liver Neoplasms arsenic trioxide 21.4114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.4121137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.4119294768
MESH:D008113 Liver Neoplasms Fluorouracil 21.4117045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 21.4120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.4116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.072876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 18.0720377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.0712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 18.07598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.0712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2815213294
MESH:D008171 Lung Diseases Acetylcysteine 3.9912815614
MESH:D008175 Lung Neoplasms arsenic trioxide 6.4811798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4820135361 20869020 18520028 18569708 6695378 18816296 17053015 20064080 20464547
MESH:D008175 Lung Neoplasms Fluorouracil 6.4815246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.4816271038 17909032 16337739 10545420 9230183 20512841 15390079 6695378 21163286 20970405 1399818 11893704 7750092
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4819555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7115086387
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 6.1512807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1511408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008545 Melanoma epigallocatechin gallate 4.2311746506 17992120
MESH:D008545 Melanoma N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 4.2316487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.3016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.3016757204 18986760
MESH:D052016 Mucositis irinotecan 4.9217159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0419549372 19417148 15949261 14977855 11468182
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.4117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0916882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0216411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.0618551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.0618551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8716624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 6.2214720322
MESH:D009362 Neoplasm Metastasis irinotecan 6.2218259882
MESH:D009369 Neoplasms Benzo(a)pyrene 7.9611141357
MESH:D009369 Neoplasms Fluorouracil 7.9618600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 7.9617405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009421 Nervous System Malformations Estradiol 9.1811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1814600291
MESH:D009436 Neural Tube Defects Acetylcysteine 7.4719446573
MESH:D009436 Neural Tube Defects arsenic trioxide 7.4710525206
MESH:D009447 Neuroblastoma irinotecan 3.438761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.648761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3816436463
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.7012819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.7016049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.7014694615
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.7419769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 4.7419401270
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.6815580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.6819003803 15113037 16929163 16500647
MESH:D010190 Pancreatic Neoplasms N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 8.6811504793
MESH:D010235 Paraganglioma arsenic trioxide 4.0819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1111896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0819082440 18626508
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9315538739 18286688 16160472 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.4412210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8716646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.6718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6718551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3310029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3316192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6717007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.6720155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 4.6716951190 17172411 18567086 19084572 19015929 17498489 15786421 16424979 17522103 18396642
MESH:D013274 Stomach Neoplasms irinotecan 4.6715723263
MESH:D013276 Stomach Ulcer Acetylcysteine 3.9217918041
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.0219014326
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9116280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8815213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.6316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.6316049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.6311780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.6317053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.7010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.7010091137
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8016803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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