AutismKB 2.0

Annotation Detail for SPAG5


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Basic Information Top
Gene Symbol:SPAG5 ( DEEPEST,MAP126,hMAP126 )
Gene Full Name: sperm associated antigen 5
Band: 17q11.2
Quick LinksEntrez ID:10615; OMIM: NA; Uniprot ID:SPAG5_HUMAN; ENSEMBL ID: ENSG00000076382; HGNC ID: 13452
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SPAG5 mRNAincreases expression 19031421
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of SPAG5 mRNAincreases expression 20713471
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SPAG5 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SPAG5 mRNAaffects expression 16483693
D001374 Azacitidine [Azacitidine co-treated with Thalidomide] affects the expression of SPAG5 mRNAaffects cotreatment|affects expression 18720364
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SPAG5 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SPAG5 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SPAG5 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SPAG5 mRNAdecreases expression 20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of SPAG5 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SPAG5 mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SPAG5 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SPAG5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPAG5 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of SPAG5 mRNAdecreases expression 18035473
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of SPAG5 mRNA]affects reaction|decreases expression 15016801
D019833 Genistein Genistein affects the expression of SPAG5 mRNAaffects expression 18847459
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of SPAG5 mRNAincreases expression 20713471
D009532 Nickel Nickel results in increased expression of SPAG5 mRNAincreases expression 19031421
D010126 Ozone Ozone results in increased expression of SPAG5 mRNAincreases expression 12763052
D010126 Ozone TTPA protein affects the reaction [Ozone results in increased expression of SPAG5 mRNA]affects reaction|increases expression 19555225
D010634 Phenobarbital Phenobarbital affects the expression of SPAG5 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of SPAG5 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in increased expression of SPAG5 mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of SPAG5 mRNA]increases expression|increases reaction 17950772
C017947 sodium arsenite sodium arsenite results in decreased expression of SPAG5 mRNAdecreases expression 17998272
D013629 Tamoxifen Tamoxifen affects the expression of SPAG5 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPAG5 mRNAaffects cotreatment|increases expression 17942748
D013750 Tetrachloroethylene Tetrachloroethylene results in increased expression of SPAG5 mRNAincreases expression 19031421
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of SPAG5 mRNAincreases expression 19031421
D013792 Thalidomide [Azacitidine co-treated with Thalidomide] affects the expression of SPAG5 mRNAaffects cotreatment|affects expression 18720364
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.236195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.2314514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 13.238333272
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D055371 Acute Lung Injury Nickel 8.6516166738
MESH:D055371 Acute Lung Injury pirinixic acid 8.6518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7720127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7714692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.7717638652
MESH:D000230 Adenocarcinoma Genistein 9.7711473722
MESH:D000236 Adenoma Benzo(a)pyrene 15.126695378
MESH:D000236 Adenoma beta-Naphthoflavone 15.1219389873
MESH:D000236 Adenoma Diethylnitrosamine 15.126695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 15.1210545420 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.2719052882 17162532 16434500 17620307 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.2716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.2716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7117306315 16712894
MESH:D000544 Alzheimer Disease Ozone 2.4015513908
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.2416510725
MESH:D000740 Anemia Fluorouracil 8.1316511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2415885639
MESH:D001169 Arthritis, Experimental Thalidomide 7.249598899
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Ozone 2.5816373670 17854713
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3411922910
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 6.8211921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.8217474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.8217474063
MESH:D001943 Breast Neoplasms Fluorouracil 6.8215136595 16110121 19217205 16557594 18357371 16595493 18608205
MESH:D001943 Breast Neoplasms Genistein 6.8216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylcholanthrene 6.8217474063
MESH:D001943 Breast Neoplasms Nickel 6.8215986119
MESH:D001943 Breast Neoplasms Tamoxifen 6.8217261762 19288272 20065188 17440819 11161223 19487384 19200415 17893378 19155303 18815881 21152245 17049068 18425577 18855134 17242785 16202921 19066611 19221464 16818667 18629630 18821012 20859285 18984771 19011961 19289846 20390343 19244106 20544844 18997820 19115204 16273361 19142967 20135344 21138602 19059307 19084267 19103187 16873071 20005174 19410462 15565566 19189212 15668708 18351453 19189210
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.8220435547
MESH:D001943 Breast Neoplasms Tetrachloroethylene 6.8215986119
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5315516495 18315731 16777450 19059883 18417511 17626835 14754758
MESH:D002100 Cachexia Ozone 4.5516183385
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4816051944
MESH:D002277 Carcinoma Fluorouracil 13.1217121937
MESH:D002277 Carcinoma Methylcholanthrene 13.1210545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.1216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.3912907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.3917978847 20935162 18506893 16698587 19052882 18665156 16288022 20084675 19171122 20727157 20007298 19383236 19701751 18494052 17761372 18788625 16502159 16830150 16779866 20101231 18210153 16540662 18393292 10672840 19822196 16569478 21159647 20512989 19335982 20214788 17173139 19919837 3084413 17428255 19208518 18691550 3581430 18971187 17138121 20514400 16328049 10737359 19539802 18056438 11831363 19519916 18978308 20524982 16935385 16681979 16807293 18785209 20432363 17162532 16878318 19394651 19107877 19418558 17055752
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.3917971768 18930000 17088986 16799960 17045692 16332177
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.3916924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.3920007298 6705139 17173139 1701930 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.3916507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.3916924424
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 16.3916313753
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.3620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.3618986760 16757204 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.3618572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 10.3618922899
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.1716332659
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.7220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.7212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.727505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 19.7216192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 19.7220056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.064080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 15.2719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 15.2716835633
MESH:D018281 Cholangiocarcinoma Thalidomide 15.2718291259
MESH:D002779 Cholestasis Cyclosporine 12.5319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.5316105132 11677210 17681005 17110522 16919318 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 12.5319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 16354765 15668235 15340226 8697196
MESH:D003092 Colitis Thalidomide 4.6616680017
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7317016597 17018589 17172411 16340194 17725105 15001691 18772588 16510598 17287894 17169374
MESH:D003110 Colonic Neoplasms Genistein 3.7317182828
MESH:D015179 Colorectal Neoplasms Azacitidine 2.8219934284
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8215289873 18509181 17594712 14970324 17695437 18383874 18949393 16331619 18288408 15148649 17016601 20501625 17094418 16524972 18448328 17401013 16391804 17454858 18802399 16303861 16282729 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D016510 Corneal Neovascularization Thalidomide 5.389301478
MESH:D003389 Cranial Nerve Diseases Thalidomide 6.119200351
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8120055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Thalidomide 2.819200351
MESH:D003424 Crohn Disease Thalidomide 4.0716078585
MESH:D007644 Darier Disease Fluorouracil 4.6016733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.7717100760 19470301 17244072
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003877 Dermatitis, Contact Nickel 4.462952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8220387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3219279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.5419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004421 Dystonia Phenobarbital 3.831851702
MESH:D004487 Edema pirinixic acid 10.4712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4711000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 10.477812673 16716910 8113982 8273558 11698051 15177302 9599246
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7118230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3319031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.4016402032
MESH:D016889 Endometrial Neoplasms Genistein 7.1211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.1217893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.869294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.923659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.386401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.833659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.9316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.9316785472 16481741 17638652 16337965 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver Cyclosporine 22.7919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.7921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.7915345470
MESH:D005234 Fatty Liver pirinixic acid 22.7919236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 22.7914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7514633661 10962813
MESH:D005355 Fibrosis Cyclosporine 7.8512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.8520067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4916452187
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 6.1112701121
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma Genistein 3.1416598420
MESH:D005910 Glioma Fluorouracil 6.2116145905
MESH:D005910 Glioma Thalidomide 6.2116327979
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.2618337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006529 Hepatomegaly Phenobarbital 13.2916109766
MESH:D006529 Hepatomegaly pirinixic acid 13.2918467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.2912621046 15340226 16120746
MESH:D015658 HIV Infections Nickel 3.7217263646
MESH:D006689 Hodgkin Disease sodium arsenite 3.0012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8516959395 15340226 16354765 8697196 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006973 Hypertension Cyclosporine 4.7010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2217937319
MESH:D007248 Infertility, Male sodium arsenite 6.2215346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 22.7518785209
MESH:D007249 Inflammation Flavonoids 22.7517296493
MESH:D007249 Inflammation Nickel 22.7516166738
MESH:D007249 Inflammation Tamoxifen 22.7519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 22.7512200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 22.7515177302 11698051 7812673 7562506 8273558
MESH:D007249 Inflammation Thalidomide 22.7516134734
MESH:D007333 Insulin Resistance pirinixic acid 2.5116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Cyclosporine 5.658314463 18776723 10903974
MESH:D007674 Kidney Diseases sodium arsenite 5.6520008137
MESH:D007680 Kidney Neoplasms Cyclosporine 11.5212371664
MESH:D007680 Kidney Neoplasms Fluorouracil 11.5216985049
MESH:D007680 Kidney Neoplasms Tamoxifen 11.5218625569
MESH:D007898 Leishmaniasis, Visceral Thalidomide 4.2016514283
MESH:D007938 Leukemia Azacitidine 6.4419148494
MESH:D007938 Leukemia Genistein 6.4417468513 18980019
MESH:D007951 Leukemia, Myeloid Azacitidine 4.4519077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.5018720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 4.5018720364
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.0119299654
MESH:D017880 Limb Deformities, Congenital Thalidomide 4.3210473037
MESH:D008064 Lipidoses Tamoxifen 3.0215342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.5818665156 18407596 18522880 19638242 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 10.5821047994
MESH:D008103 Liver Cirrhosis Thalidomide 10.5817174718 16943688
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.4917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 6.4915465738
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4717034775
MESH:D008107 Liver Diseases Phenobarbital 6.4719363144
MESH:D008107 Liver Diseases Tetrachloroethylene 6.4717267091
MESH:D008113 Liver Neoplasms Aflatoxin B1 32.952125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 32.9521137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 32.9519389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 32.9520452335 21167192 16942905 19642983 12771043 19255062 18754104 15885732 19254457 20501860 21047994 19833225 18644402 19996281 20137499 18978307 20101389 9163691 12112319 2422723 18648771 19850985 19812893 10737359 19426721 20492335 19690152 20583210 21278145 20118626 19499222 19090486 19427195 20405173 19638242 2862719 19073162 19551842 18977376 20434301 19294768 19256749 15175105 21071580
MESH:D008113 Liver Neoplasms Fluorouracil 32.9517045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 32.9521047994 15975961 19812893 19073162 19482888 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 32.9516377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 32.9515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 32.9516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 32.9516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 26.478603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 26.4718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.4718308698 19126423 19004024 18775883 2563599 3124819 19519916 18079962 18164116 18544905 18253720 17854601 19009564 17174075 16267830 9362446 16842330 19539802 18093689 21159647 17942915 18282651
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 26.47598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 26.4718308698 17172636 6150874 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.4712151625
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 26.477955063
MESH:D008171 Lung Diseases Ozone 7.0919066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.0919095001
MESH:D055370 Lung Injury Ozone 3.6620417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 20.0614755239
MESH:D008175 Lung Neoplasms Azacitidine 20.0621224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 20.0618520028 20869020 17053015 20464547 6695378 20064080 18569708 18816296 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 20.0621163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Fluorouracil 20.0615246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 20.0616271038 9230183 17909032 21163286 11893704 16337739 10545420 20970405 15390079 6695378 7750092 1399818 20512841
MESH:D008175 Lung Neoplasms Ozone 20.067614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 20.0617306315 15276417 17077188 19931552 16712894
MESH:D008175 Lung Neoplasms Tamoxifen 20.0618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 20.0619555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 20.0611807781
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6015086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 13.3511921183
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.3512929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.3519196722 11731420 19196723 14580682 16827153
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 13.358985016
MESH:D020149 Manganese Poisoning Tamoxifen 4.3519453300
MESH:D008545 Melanoma sodium arsenite 5.0519082730 16487513
MESH:D008545 Melanoma Tamoxifen 5.0519393235 12393984
MESH:D008545 Melanoma Thalidomide 5.0512829675 16098027 17089043
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D008679 Metaplasia Ozone 4.9110496685
MESH:D009006 Monosomy Azacitidine 5.8919299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.0516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.0516757204 18986760
MESH:D009101 Multiple Myeloma Azacitidine 7.5618443271 19549372
MESH:D009101 Multiple Myeloma Thalidomide 7.5615741222 15867202 15920492 19372569 16445831 19112817 19112201 17168659 15744524 15939924
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 7.7718720364 19805378 17596541 17611569
MESH:D009190 Myelodysplastic Syndromes Thalidomide 7.7718720364
MESH:D009203 Myocardial Infarction Genistein 5.4117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.9117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2817484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.489029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.7511141357
MESH:D009369 Neoplasms Fluorouracil 14.7516928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 14.7517405874
MESH:D009369 Neoplasms sodium arsenite 14.7511559025
MESH:D009369 Neoplasms Tetrachloroethylene 14.7511911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009421 Nervous System Malformations Genistein 15.4716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.4714600291
MESH:D009421 Nervous System Malformations Thalidomide 15.4716859833
MESH:D009436 Neural Tube Defects sodium arsenite 3.0212854658
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3116436463
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D010018 Osteomalacia Phenobarbital 4.1717016548
MESH:D010024 Osteoporosis Genistein 3.1419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9116169203
MESH:D010051 Ovarian Neoplasms Genistein 7.7319005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.7315276417 17306315
MESH:D010051 Ovarian Neoplasms Thalidomide 7.7316288038
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.8016540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.8019003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.8016965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 11.8015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.1118404319 8330346 12065085 18922899
MESH:D010291 Paresis Thalidomide 6.119200351
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010538 Peritonitis Ozone 3.9416369182
MESH:D011014 Pneumonia Ozone 4.2018929643 18007984 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.3412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.342563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.342563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 4.1217031469
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0011118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms Azacitidine 2.0818324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0818626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.0815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0815067354
MESH:D011471 Prostatic Neoplasms Thalidomide 2.0816729912
MESH:D011536 Prurigo Thalidomide 6.1112755975
MESH:D011537 Pruritus Ethinyl Estradiol 3.1216919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.3012752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8515538739 16160472 18286688 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D019873 Schnitzler Syndrome Thalidomide 5.7516096327
MESH:D012640 Seizures Phenobarbital 2.5711442880 4039156 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.636407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.8419755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 12.8418572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.8416192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.848330346 12065085 18404319 8985016 11807781
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9216709447
MESH:D013088 Spermatocele Tamoxifen 10.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6512854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2520155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2518456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2515786421 16424979 16951190 17522103 19084572 17498489 18567086 17172411 18396642 19015929
MESH:D013276 Stomach Ulcer Thalidomide 4.0015138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.707505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.701399818
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8216280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.8717053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.8716452187 16712894 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.8717572228 16712894 8653321
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.9316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.9311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1214692618
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D014652 Vascular Diseases sodium arsenite 11.4817056641
MESH:D014652 Vascular Diseases Thalidomide 11.4815741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3715869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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