AutismKB 2.0

Annotation Detail for CENPE


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Basic Information Top
Gene Symbol:CENPE ( KIF10 )
Gene Full Name: centromere protein E, 312kDa
Band: 4q24
Quick LinksEntrez ID:1062; OMIM: 117143; Uniprot ID:CENPE_HUMAN; ENSEMBL ID: ENSG00000138778; HGNC ID: 1856
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Pathway IDPathway Name
200087PLK1 signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CENPE mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CENPE proteinaffects expression 20106945
D006710 Homocysteine Homocysteine results in decreased expression of CENPE mRNAdecreases expression 17326132
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CENPE mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CENPE mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CENPE mRNAdecreases expression 20382639
20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CENPE mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of CENPE mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CENPE mRNAdecreases expression 17555576
D019833 Genistein Genistein affects the expression of CENPE mRNAaffects expression 18847459
C029424 hydrazine hydrazine results in increased expression of CENPE mRNAincreases expression 15282401
C051890 irinotecan irinotecan analog results in decreased expression of CENPE mRNAdecreases expression 18927307
C051890 irinotecan irinotecan metabolite results in decreased expression of CENPE mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of CENPE mRNAdecreases expression 15956246
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of CENPE mRNAincreases expression 20713471
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CENPE mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CENPE mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of CENPE mRNA]increases expression|increases reaction 17950772
C059514 resveratrol resveratrol results in decreased expression of CENPE mRNAdecreases expression 15767336
C017947 sodium arsenite sodium arsenite results in decreased expression of CENPE mRNAdecreases expression 12679051
C017947 sodium arsenite sodium arsenite results in decreased expression of CENPE mRNAdecreases expression 17998272
D018038 Sodium Selenite Sodium Selenite results in decreased expression of CENPE mRNAdecreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of CENPE mRNAaffects expression 17555576
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of CENPE mRNAdecreases expression 17951470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D058186 Acute Kidney Injury resveratrol 3.8116538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9920127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9914692618
MESH:D000230 Adenocarcinoma Genistein 6.9911473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 15.813712494
MESH:D000236 Adenoma Benzo(a)pyrene 15.816695378
MESH:D000236 Adenoma Methylcholanthrene 15.8110545420 6695378
MESH:D000236 Adenoma resveratrol 15.8115688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4416434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8716712894 17306315
MESH:D000544 Alzheimer Disease resveratrol 2.5616162502 16183991
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2715885639
MESH:D001169 Arthritis, Experimental resveratrol 7.2717115116
MESH:D050197 Atherosclerosis Methylcholanthrene 6.8811922910
MESH:D050197 Atherosclerosis resveratrol 6.8817967414 16873680
MESH:D001321 Autistic Disorder Homocysteine 3.0420468076 16297937
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9911289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1119483382
MESH:D002545 Brain Ischemia resveratrol 4.2517600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3420146248 17474063
MESH:D001943 Breast Neoplasms Genistein 2.3416873071 16541309 17200150
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.3417474063
MESH:D001943 Breast Neoplasms resveratrol 2.3417534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 2.3419288272 18855134 19103187 15668708 19244106 19189210 19155303 19142967 19200415 16202921 19289846 19084267 18821012 19011961 20390343 18351453 19066611 19189212 16273361 19221464 20135344 17049068 20005174 21138602 18984771 19410462 21152245 17440819 11161223 18815881 17242785 16873071 18629630 20544844 18425577 17893378 19059307 15565566 20065188 19487384 18997820 19115204 17261762 16818667 20859285
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7416050911 10355542 16192424 16097048 15700767 16011737 15721981 18705752 15673190 3786805 16227642 16124888
MESH:D002277 Carcinoma Methylcholanthrene 3.9310545420
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 14.007296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 14.0012619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.0018788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 14.0016924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 14.0016227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 14.0015276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.0016924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5616675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.657296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.5020419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.5016227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.5018572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D002318 Cardiovascular Diseases Genistein 7.4116332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.4115458977
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 20.787505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.7820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.7812371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 20.7816192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 20.7819524636 20056578
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.9419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 18.9419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.9417681005 17333356 16919318 15861022 16105132 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 18.9419176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7115894690
MESH:D003092 Colitis resveratrol 4.0916474422
MESH:D003110 Colonic Neoplasms Genistein 5.9117182828
MESH:D003110 Colonic Neoplasms irinotecan 5.9117287894 17725105
MESH:D003110 Colonic Neoplasms resveratrol 5.9116338953
MESH:D015179 Colorectal Neoplasms irinotecan 2.8015273666 17454858 16391804 17159606 18259882 16303861 18509181
MESH:D015179 Colorectal Neoplasms resveratrol 2.8016550006
MESH:D003324 Coronary Artery Disease Homocysteine 3.7416379339
MESH:D003327 Coronary Disease resveratrol 3.7216507316
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7712868966 11298694 8156756 18759878 11906362 8970840 2524372 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.453621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7416285004
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7316873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4816647724
MESH:D003928 Diabetic Nephropathies resveratrol 8.9116286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.9119279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.2016192314 9328219 11289319 1440618 18648102 18289764 6482804 8291058 7440962 18692083 6679447 9022650 9653073
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.206623471 2869522 21278145 16227642 15998439 10915739 3732212 17522070 10092053 4309450 7179309 15968718 15027814 9327722 3786805 11566570 6884620 7440962 7120509 16177239 19336974 19085960
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.2015131321
MESH:D004487 Edema pirinixic acid 6.7712083418
MESH:D004487 Edema resveratrol 6.778985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.1212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 15.1217872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.1219031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.5516402032
MESH:D016889 Endometrial Neoplasms Genistein 7.4311473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.4316202921 17893378 19155303 20544844
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8117923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.123581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1216530937
MESH:D017889 Exfoliation Syndrome Homocysteine 5.6716504073
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.2116239168 15959796 16045604 12795759 61145 12631006 19224547 17595544
MESH:D005234 Fatty Liver Cyclosporine 24.2119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2115345470
MESH:D005234 Fatty Liver pirinixic acid 24.2119236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 24.2119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9010962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 8.5418705752
MESH:D005355 Fibrosis Cyclosporine 8.5412168785 12639820
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D005901 Glaucoma Homocysteine 5.2516504073
MESH:D005909 Glioblastoma Genistein 3.2316598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.007505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9920471113
MESH:D006330 Heart Defects, Congenital Homocysteine 6.9919638421
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.096705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.0919110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 2.9619176532 16221962 18467677 19772884
MESH:D006561 Herpes Simplex resveratrol 4.1416876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.1112676792
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D006937 Hypercholesterolemia resveratrol 3.9617188708
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.6717292331 17369066 18234410
MESH:D006949 Hyperlipidemias resveratrol 3.9916873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D006973 Hypertension Cyclosporine 2.0810903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2617488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6117600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5417937319
MESH:D007248 Infertility, Male sodium arsenite 6.5412646999 15346721
MESH:D007249 Inflammation resveratrol 5.1816366677
MESH:D007249 Inflammation Tamoxifen 5.1819457130
MESH:D007251 Influenza, Human resveratrol 4.5216624496
MESH:D007333 Insulin Resistance pirinixic acid 7.2116306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.2114714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.998074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Cyclosporine 5.938314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 5.9320008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.166582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.1612371664
MESH:D007680 Kidney Neoplasms Tamoxifen 12.1618625569
MESH:D007938 Leukemia Genistein 3.0017468513 18980019
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.5516087638
MESH:D008064 Lipidoses Tamoxifen 3.1217567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7811408273 16943688 17174718 16239168 17334410 17157831 21278145 16221502 11903743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9218395095 15052691 17766677 17481882 13678700 12666154 12609069 18277467 18481824 14748882 15123356 15959796 18166357 18054572 15876570 15925388 17565644 15931870 17525996 18006644 18705752 12389079 15057751 18472094 16116963 15370692 18317297 14512876 17944888 12649538 12667390 12445418 17631135 17922224 12632512 17708605 16192424 14620537 12958196 18251166 18156304 17823541 14724832 16015684 18418968 17976157 15650968 15818738 18420326 18472332 15893842 16097048 16011737 16033810 12445421 18376398 20821823 16638106 18187930 17869086 17640975 14716833 18339082 17761835 11481614 16136751 15338365 18263696 15673190 17714472 12898905 14716496 16248980 17698563 12546737 17900296 12632514 17557913 12586293 18412020 12741479 16027843 18395914 15730626 15996030 15362042 18205269 18210741 17805973 18429990 18279442 10355542 17721639
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.9217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9215474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9218564211
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0715720792 16246199 16964402 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6514706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.6715890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.6720195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.6719294768
MESH:D008113 Liver Neoplasms pirinixic acid 21.6716377806 20007298 15890375
MESH:D008113 Liver Neoplasms resveratrol 21.6719073162 19321006 19812893 20405173
MESH:D008113 Liver Neoplasms sodium arsenite 21.6715276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 21.6716684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.94598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.948603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.9415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 13.94598648 1399818
MESH:D008171 Lung Diseases sodium arsenite 3.1419095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.5514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5518816296 20064080 20464547 18520028 18569708 20869020 6695378 17053015 20135361
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.5516271038 17909032 15390079 7750092 20970405 16337739 1399818 11893704 9230183 6695378 20512841 21163286 10545420
MESH:D008175 Lung Neoplasms sodium arsenite 6.5516712894 17077188 19931552 17306315 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 6.5518625569
MESH:D016393 Lymphoma, B-Cell resveratrol 10.1417088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 10.1414737004
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8314749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.8815688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.8914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.898985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.8911731420 14580682 16827153 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.5219453300
MESH:D008545 Melanoma resveratrol 5.1117992120
MESH:D008545 Melanoma sodium arsenite 5.1116487513 19082730
MESH:D008545 Melanoma Tamoxifen 5.1112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D008591 Meningomyelocele Homocysteine 5.5016602021
MESH:D008659 Metabolic Diseases resveratrol 4.3417112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D052016 Mucositis irinotecan 4.9717159606
MESH:D009101 Multiple Myeloma resveratrol 3.4316490592 17935668 17049120 17164350 16267019 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8317962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction Genistein 13.4617141266
MESH:D009203 Myocardial Infarction Homocysteine 13.4617412321
MESH:D009203 Myocardial Infarction pirinixic acid 13.4619151258
MESH:D009203 Myocardial Infarction resveratrol 13.4616456233 17125593 17188708 16317513 16525036 17015251
MESH:D017202 Myocardial Ischemia resveratrol 3.9717125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.2717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2716411023
MESH:D009205 Myocarditis resveratrol 4.7217322642
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.443581430
MESH:D009362 Neoplasm Metastasis irinotecan 9.4418259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.4419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0811141357
MESH:D009369 Neoplasms pirinixic acid 8.0817405874
MESH:D009369 Neoplasms sodium arsenite 8.0811559025
MESH:D009374 Neoplasms, Experimental resveratrol 9.108985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.1020056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009421 Nervous System Malformations Genistein 3.9916427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.166679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.1612854658
MESH:D009447 Neuroblastoma irinotecan 3.468761367
MESH:D019636 Neurodegenerative Diseases resveratrol 3.7717652729
MESH:D017599 Neuroectodermal Tumors irinotecan 4.698761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.3617929310
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.386482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D010024 Osteoporosis Genistein 3.2219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.0216169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.0217513867
MESH:D010051 Ovarian Neoplasms Genistein 4.9319005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9317306315 15276417
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.447296757
MESH:D010300 Parkinson Disease Homocysteine 3.5616275827
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.446228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.1416679765
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Genistein 1.8915378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms resveratrol 1.8915767336 17675339 16731767 17804756 17718901 17636462
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8918760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5516325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.5019058328
MESH:D015427 Reperfusion Injury resveratrol 6.5015827377 16314181 17520802 17058453 16317513
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.343692021
MESH:D012559 Schizophrenia Homocysteine 3.1016641680
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.4110029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 9.418985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 9.4119524636 18572023
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7612854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.542093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 2.5415723263
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4416321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.857505956 3712494 6582329 1399818 6587162
MESH:D014062 Tongue Neoplasms resveratrol 4.1716227395
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.788074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.7817053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.7817306315 16712894 16452187 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.7816712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.4317473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.4311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.3614692618
MESH:D014594 Uterine Neoplasms resveratrol 9.3617044934
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3917056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5015869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2617488730
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:604 Hemostasis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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