AutismKB 2.0

Annotation Detail for TXNIP


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Basic Information Top
Gene Symbol:TXNIP ( EST01027,HHCPA78,THIF,VDUP1 )
Gene Full Name: thioredoxin interacting protein
Band: 1q21.1
Quick LinksEntrez ID:10628; OMIM: 606599; Uniprot ID:TXNIP_HUMAN; ENSEMBL ID: ENSG00000117289; HGNC ID: 16952
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
1944Breast cancer
2094Ulcerative colitis
2097Hyperlipidemia
2106Pancreas cancer
Desease Name
CARDIOVASCULAR
blood pressure, arterial hypertriglyceridemia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C097949 1,25-dihydroxyvitamin D 1,25-dihydroxyvitamin D results in increased expression of TXNIP mRNAincreases expression 16061374
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TXNIP mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TXNIP mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TXNIP proteinaffects expression 20106945
C002055 allose [allose co-treated with Fluorouracil] results in increased expression of TXNIP proteinaffects cotreatment|increases expression 18930000
C002055 allose allose results in increased expression of TXNIP mRNAincreases expression 18930000
C002055 allose allose results in increased expression of TXNIP proteinincreases expression 18930000
C002055 allose Fluorouracil promotes the reaction [allose results in increased expression of TXNIP mRNA]increases expression|increases reaction 18930000
C103505 AM 251 AM 251 results in increased expression of TXNIP mRNAincreases expression 16500647
C058317 arsenic disulfide arsenic disulfide affects the expression of TXNIP mRNAaffects expression 16562669
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TXNIP mRNAdecreases expression 15725085
18231732
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of TXNIP mRNAaffects cotreatment|decreases expression 17905399
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TXNIP mRNAincreases expression 17879257
20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TXNIP mRNAdecreases expression 15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TXNIP mRNAincreases expression 15003993
15336504
14729362
D020122 tert-Butylhydroperoxide TXNIP protein results in decreased susceptibility to tert-Butylhydroperoxidedecreases response to substance 15003993
D016572 Cyclosporine Cyclosporine affects the expression of TXNIP mRNAaffects expression 20106945
C014347 decitabine decitabine results in increased expression of TXNIP mRNAincreases expression 19194470
D003907 Dexamethasone Dexamethasone results in increased expression of TXNIP mRNAincreases expression 12782123
D002117 Calcitriol Calcitriol results in decreased expression of TXNIP mRNAdecreases expression 16002434
D004317 Doxorubicin Doxorubicin affects the expression of TXNIP mRNAaffects expression 16243910
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TXNIP mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of TXNIP mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TXNIP mRNAdecreases expression 17351261
C020326 ferric nitrilotriacetate ferric nitrilotriacetate results in decreased expression of TXNIP proteindecreases expression 15834431
C020326 ferric nitrilotriacetate ferric nitrilotriacetate results in increased methylation of TXNIP promoterincreases methylation 15834431
D005472 Fluorouracil [allose co-treated with Fluorouracil] results in increased expression of TXNIP proteinaffects cotreatment|increases expression 18930000
D005472 Fluorouracil Fluorouracil promotes the reaction [allose results in increased expression of TXNIP mRNA]increases expression|increases reaction 18930000
D005472 Fluorouracil Fluorouracil results in increased expression of TXNIP mRNAincreases expression 18930000
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of TXNIP mRNA]affects reaction|decreases expression 15016801
D005472 Fluorouracil TXNIP protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D005492 Folic Acid Folic Acid results in increased expression of TXNIP mRNAincreases expression 11723236
C106014 gedunin gedunin results in decreased expression of TXNIP mRNAdecreases expression 17010675
D007213 Indomethacin Indomethacin results in decreased expression of TXNIP mRNAdecreases expression 16984733
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of TXNIP mRNAaffects cotreatment|decreases expression 17905399
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of TXNIP mRNAdecreases expression 17616710
C016340 o,p'-DDT o,p'-DDT results in decreased expression of TXNIP mRNAdecreases expression 19371625
D010269 Paraquat TXNIP protein results in increased susceptibility to Paraquatincreases response to substance 12054598
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of TXNIP mRNAincreases expression 16221955
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TXNIP mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TXNIP mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of TXNIP mRNAincreases expression 18445702
17426115
18301758
D011374 Progesterone Progesterone results in decreased expression of TXNIP mRNAdecreases expression 18037150
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in decreased expression of TXNIP mRNAaffects cotreatment|decreases expression 19059307
D017382 Reactive Oxygen Species TXNIP protein promotes the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]increases abundance|increases reaction 15123525
C059514 resveratrol resveratrol results in decreased expression of TXNIP mRNAdecreases expression 19371625
D012402 Rotenone Rotenone results in increased expression of TXNIP mRNAincreases expression 19013527
C009277 sodium arsenate sodium arsenate results in increased expression of TXNIP mRNAincreases expression 16882884
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TXNIP mRNAaffects cotreatment|decreases expression 19059307
C004648 testosterone enanthate testosterone enanthate affects the expression of TXNIP mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TXNIP mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TXNIP mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TXNIP mRNAincreases expression 20106945
D019772 Topotecan TXNIP protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of TXNIP mRNAaffects cotreatment|decreases expression 17905399
C050414 tripterine tripterine results in decreased expression of TXNIP mRNAdecreases expression 17010675
C025643 vinclozolin vinclozolin affects the expression of TXNIP mRNAaffects expression 19015723
C111237 vorinostat vorinostat results in increased expression of TXNIP mRNAincreases expression 17218635
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0714745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.766195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.7614514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4717505938
MESH:D058186 Acute Kidney Injury Folic Acid 7.6516595132 16316344 17003819
MESH:D058186 Acute Kidney Injury resveratrol 7.6516538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.6918653653
MESH:D000230 Adenocarcinoma arsenic trioxide 18.7211798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 18.7220127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 18.7217418594
MESH:D000230 Adenocarcinoma Estradiol 18.7211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 18.7214692618
MESH:D000230 Adenocarcinoma Fluorouracil 18.7217638652
MESH:D000230 Adenocarcinoma Indomethacin 18.7216537180
MESH:D000236 Adenoma Benzo(a)pyrene 13.746695378
MESH:D000236 Adenoma Folic Acid 13.7416963246
MESH:D000236 Adenoma Indomethacin 13.7411497255
MESH:D000236 Adenoma resveratrol 13.7415688382
MESH:D018248 Adenoma, Liver Cell Phenobarbital 14.5917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.5916835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.3111874814
MESH:D000419 Albuminuria Doxorubicin 9.9921441931
MESH:D000419 Albuminuria Raloxifene 9.9917451421 17308373
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9017225004
MESH:D000544 Alzheimer Disease Folic Acid 8.4517116317
MESH:D000544 Alzheimer Disease Indomethacin 8.4517627676 15579461
MESH:D000544 Alzheimer Disease Raloxifene 8.4515800139
MESH:D000544 Alzheimer Disease resveratrol 8.4516183991 16162502
MESH:D000740 Anemia Fluorouracil 7.3415504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.3411748828
MESH:D000741 Anemia, Aplastic Benzene 4.0111369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 3.3710982225
MESH:D001008 Anxiety Disorders vinclozolin 3.2719015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.4110231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.2019183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.2010388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0111256880
MESH:D018771 Arthralgia Indomethacin 4.692160914
MESH:D001169 Arthritis, Experimental Dexamethasone 10.6117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.6115885639
MESH:D001169 Arthritis, Experimental resveratrol 10.6117115116
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7011248219
MESH:D050197 Atherosclerosis resveratrol 2.9917967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001477 Bartter Syndrome Indomethacin 4.5310684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 12.8716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.8719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.8712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4615746008
MESH:D001855 Bone Marrow Diseases Benzene 4.7616183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2214601052
MESH:D001929 Brain Edema Indomethacin 4.5511481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8617868700
MESH:D001930 Brain Injuries Progesterone 9.4615845082 15665606 15380490
MESH:D001930 Brain Injuries Raloxifene 9.4616580743
MESH:D002545 Brain Ischemia Indomethacin 8.8112524144
MESH:D002545 Brain Ischemia resveratrol 8.8117600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.4117150277
MESH:D001943 Breast Neoplasms Benzene 14.9111921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 14.9117474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 14.9111237771
MESH:D001943 Breast Neoplasms decitabine 14.9118320071 19208741
MESH:D001943 Breast Neoplasms Doxorubicin 14.9111325840 18695136 19526202 17426702 18234424 16595493 16115903 15634643 17983394 16264153 17369602 15994142 15668708 16826403 15939500 16935488 16322301 15692762 15993339 16096432 15567936 15136595 18628466 18382427
MESH:D001943 Breast Neoplasms Estradiol 14.9119861407 17289903 14630087 12948864 17018787 16675129 18497071 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 14.9118608205 18357371 19217205 16110121 16557594 15136595 16595493
MESH:D001943 Breast Neoplasms Folic Acid 14.9116777985
MESH:D001943 Breast Neoplasms Indomethacin 14.9117401462
MESH:D001943 Breast Neoplasms Progesterone 14.9115562024 17614352 16175315
MESH:D001943 Breast Neoplasms Raloxifene 14.9115775269 17242785 17893378 17595753 17261762 16912660 17440819 15572757 17952589 15758505 17049068 16837676
MESH:D001943 Breast Neoplasms resveratrol 14.9116393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 14.9119189212 18997820 21138602 19200415 19084267 16873071 20544844 20005174 17049068 18984771 19487384 17261762 17893378 19066611 18815881 20065188 15565566 18629630 19410462 11161223 19115204 16818667 19288272 17440819 19221464 19142967 19011961 16273361 19189210 19059307 15668708 17242785 20859285 19155303 21152245 16202921 20135344 19289846 19103187 18425577 18855134 18351453 20390343 19244106 18821012
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 14.9120435547
MESH:D001943 Breast Neoplasms Trichloroethylene 14.9115986119
MESH:D001943 Breast Neoplasms vorinostat 14.9116144943
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9011589617
MESH:D002056 Burns Indomethacin 4.2510459503
MESH:D002100 Cachexia Indomethacin 4.5415141370 16537180 15625704 11239499
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0016111702
MESH:D002276 Carcinoid Tumor Doxorubicin 10.7716051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.7716051944
MESH:D002277 Carcinoma Fluorouracil 6.9617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0519066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 23.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 23.893084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 23.8912907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 23.8916217749 14691202 15073043 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 23.8916023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 23.8916924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 23.8917971768 16799960 17088986 17045692 18930000 16332177
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 23.8916391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 23.891701930 20007298 6705139 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular resveratrol 23.8919321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 23.8916924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 9.8811053908
MESH:D018827 Carcinoma, Lewis Lung resveratrol 9.8816675471
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8818791128 14736730 11352223
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4019014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 13.5316201981 1485588
MESH:D002292 Carcinoma, Renal Cell ferric nitrilotriacetate 13.538340253
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 13.5318695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 13.5317341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7112490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 19.5820419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 19.5811237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 19.5819215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 19.586189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 19.5818986760 16280240 17066447 16757204
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 19.5812636206 15482327
MESH:D002294 Carcinoma, Squamous Cell resveratrol 19.5816227395
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.1617572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.1617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1018850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.2216109756 17924179 15792986 16612575 17351982 17007740 16731534 17928571 16651473 16455267 15811867 17308081 15505089 17329180 17382496 17131338 18627295 17519947 16269455 16278810 16364871 16242529 17974986 16952015 15476868
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7716243910 17334414
MESH:D002318 Cardiovascular Diseases Folic Acid 10.4416755160
MESH:D002318 Cardiovascular Diseases Raloxifene 10.4415775269
MESH:D002318 Cardiovascular Diseases resveratrol 10.4415458977
MESH:D002386 Cataract Acetaminophen 2.3010977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.4912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.4918566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.804080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7716835633
MESH:D002764 Cholecystitis Indomethacin 4.6911181007
MESH:D002779 Cholestasis Cyclosporine 11.3319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.3316105132 17333356 17681005 16919318 11677210 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 11.3319176532
MESH:D002971 Cleft Lip Folic Acid 3.7221254359
MESH:D002972 Cleft Palate Folic Acid 5.398946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3912621046 8697196 15668235 16354765 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.1615800139
MESH:D003092 Colitis resveratrol 3.6816474422
MESH:D003110 Colonic Neoplasms decitabine 9.9417616700
MESH:D003110 Colonic Neoplasms Dexamethasone 9.9415824018
MESH:D003110 Colonic Neoplasms Fluorouracil 9.9416340194 17725105 17016597 17169374 17287894 15001691 16510598 18772588 17172411 17018589
MESH:D003110 Colonic Neoplasms Indomethacin 9.9415963497 15936596 15625704 11260862 15637740 15786552
MESH:D003110 Colonic Neoplasms resveratrol 9.9416338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 9.6020501625
MESH:D015179 Colorectal Neoplasms decitabine 9.6018981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 9.6018802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 9.6016391804 20501625 18802399 18949393 16303861 18288408 16524972 16282729 15148649 14970324 17401013 16331619 18448328 17016601 17454858 17255274 17594712 18383874 17695437 17094418 15289873 18509181
MESH:D015179 Colorectal Neoplasms Folic Acid 9.6016963246 17087956 17245555 17116713 16985020
MESH:D015179 Colorectal Neoplasms Indomethacin 9.6012606626 11197048 18059344 17054584
MESH:D015179 Colorectal Neoplasms resveratrol 9.6016550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6714669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.4516507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7412609071
MESH:D018352 Coronavirus Infections Indomethacin 5.2417302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 8.6310525206
MESH:D019465 Craniofacial Abnormalities Benzene 8.6315643154
MESH:D019465 Craniofacial Abnormalities Dexamethasone 8.6317728286
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 8.6315736158
MESH:D019465 Craniofacial Abnormalities sodium arsenate 8.6310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.6315322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 3.9014966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.5618551238
MESH:D007644 Darier Disease Fluorouracil 4.3316733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6715213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9119031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7717474826
MESH:D003872 Dermatitis Benzene 4.3115902427
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9812438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2018249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.3916873680
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.1216886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1217107852
MESH:D003928 Diabetic Nephropathies marker/mechanism 17582205
MESH:D003928 Diabetic Nephropathies Estradiol 18.2219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 18.2217308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies resveratrol 18.2216286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 18.2219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0417187935
MESH:D003967 Diarrhea Dexamethasone 10.997237001
MESH:D003967 Diarrhea Indomethacin 10.997907874 7237001
MESH:D003967 Diarrhea vorinostat 10.9920479100
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 13.1618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.1619164858 11461765 19370779 17906064 18713872 18071297 12392966 19739265 12958197 11287661 15619225 11739529 11421492 19416960 19923254 14725611 16393943 14550746 2444490 16781746 14986274 10915739 15968718 12540782 17562736 12705907 19085960 11529661 10663392 11743745 16485898 16177239 16227642 12153990 16081117 10774834 11834606 12594235 17522070 19420014 16109766
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 13.1617416283
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 13.1618186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.1620420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 13.167120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6219426721
MESH:D004362 Drug Toxicity Doxorubicin 6.9518602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.9511462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6818446180 16133044 18043480 17190690 12774134 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.7016699067 10671773 17351913 11595431 17329845 17202747 11535926 17045617 11595415 17151854 11991626
MESH:D004421 Dystonia Phenobarbital 3.581851702
MESH:D004485 Eczema Dexamethasone 4.0212438553
MESH:D004487 Edema Dexamethasone 26.2919703484
MESH:D004487 Edema Indomethacin 26.2919703484 7907874 7990266 10653021 8273558 8985016 16100529
MESH:D004487 Edema perfluorooctanoic acid 26.2917259670 12083418
MESH:D004487 Edema pirinixic acid 26.2912083418
MESH:D004487 Edema Raloxifene 26.2915860553
MESH:D004487 Edema resveratrol 26.298985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 26.2912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4315322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 30.0015138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 30.0012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 30.0017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 30.0015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 30.0017872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 30.0019031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.6419294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 15.2617359293
MESH:D016889 Endometrial Neoplasms Estradiol 15.2619148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Folic Acid 15.2617301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 15.2617893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Indomethacin 12.9715652904
MESH:D004715 Endometriosis Progesterone 12.9716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.9710568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6818037988
MESH:D019446 Endotoxemia Indomethacin 4.0418509659
MESH:D004751 Enteritis Indomethacin 4.2710567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 10.8617980183
MESH:D020345 Enterocolitis, Necrotizing resveratrol 10.8617923197
MESH:D004802 Eosinophilia Indomethacin 3.6111298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.653659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.4011558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.6420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.156401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.807750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.553659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 12.3212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.3216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.3216785472 17638652 16481741 15173087 16337965
MESH:D004938 Esophageal Neoplasms Indomethacin 12.3211005569
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 12.3216510608 15264214 16704527 15878914 15623463 15150132 15547721 16805852 15547733
MESH:D017889 Exfoliation Syndrome Folic Acid 5.0316504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6611564622
MESH:D005221 Fatigue vorinostat 5.1320479100
MESH:D005234 Fatty Liver arsenic trioxide 25.3315073043
MESH:D005234 Fatty Liver Cyclosporine 25.3319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.3315345470
MESH:D005234 Fatty Liver pirinixic acid 25.3320131406 19236843
MESH:D005234 Fatty Liver Raloxifene 25.3317473493
MESH:D005234 Fatty Liver Tamoxifen 25.3314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0011858732
MESH:D005334 Fever Indomethacin 3.7211852909 10431976 17627676
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0614745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.8919069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.8919069698
MESH:D005354 Fibrosarcoma Indomethacin 4.4310962813
MESH:D005355 Fibrosis Cyclosporine 12.1712639820 12168785
MESH:D005355 Fibrosis Indomethacin 12.1717994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.1720067830
MESH:D005499 Folliculitis Indomethacin 4.6911298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8216904648
MESH:D005756 Gastritis Acetaminophen 16.3616983495
MESH:D005756 Gastritis Folic Acid 16.3617171786
MESH:D005756 Gastritis Indomethacin 16.3615046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8216417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.758708960
MESH:D005901 Glaucoma Folic Acid 4.6516504073
MESH:D005909 Glioblastoma Doxorubicin 6.4117150277
MESH:D005909 Glioblastoma Indomethacin 6.4112870263
MESH:D005910 Glioma Fluorouracil 5.5716145905
MESH:D005910 Glioma Indomethacin 5.5716487511 18371953
MESH:D005911 Gliosis Paraquat 4.6911124998
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9111849393
MESH:D018149 Glucose Intolerance sodium arsenate 4.6519446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1210696789
MESH:D006073 Gout Indomethacin 4.8811248219
MESH:D006258 Head and Neck Neoplasms decitabine 15.8619215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 15.8615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 15.8615162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Indomethacin 15.8615482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.7020471113
MESH:D006330 Heart Defects, Congenital Folic Acid 9.7016524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.7010048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 6.7512587719 16244372 14766674 17875725 16244371 16495754 18674790 18006777 16330681 17888722 16144979 16707910 16879835
MESH:D006331 Heart Diseases Raloxifene 6.7511110106
MESH:D006333 Heart Failure Doxorubicin 6.0617481944
MESH:D006333 Heart Failure pirinixic acid 6.0620558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4915692506
MESH:D006402 Hematologic Diseases Benzene 4.2216183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9211000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1515633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2415135802
MESH:D006529 Hepatomegaly perfluorooctanoic acid 16.973609246
MESH:D006529 Hepatomegaly Phenobarbital 16.9716109766
MESH:D006529 Hepatomegaly pirinixic acid 16.9719176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.9716120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.897520565
MESH:D006558 Herpes Genitalis Estradiol 4.5615709030
MESH:D006561 Herpes Simplex resveratrol 3.7216876885
MESH:D006679 HIV Seropositivity Folic Acid 5.0317209195
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.2717440010
MESH:D006689 Hodgkin Disease Doxorubicin 3.0318501091 17606976 15147373
MESH:D019584 Hot Flashes Estradiol 3.2817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5715340226 18606429 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 11.0316870215
MESH:D006930 Hyperalgesia Indomethacin 11.0312727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 11.0312083418
MESH:D034321 Hyperamylasemia Indomethacin 5.2417883296
MESH:D006937 Hypercholesterolemia resveratrol 3.5917188708
MESH:D006940 Hyperemia Indomethacin 4.5412524144
MESH:D006943 Hyperglycemia pirinixic acid 2.7820558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.1016865747 16755160 16395265 16397167 16433478
MESH:D006949 Hyperlipidemias Indomethacin 8.0717546600
MESH:D006949 Hyperlipidemias resveratrol 8.0716873680
MESH:D006973 Hypertension Benzene 14.3017940673
MESH:D006973 Hypertension Cyclosporine 14.3010903974
MESH:D006973 Hypertension Dexamethasone 14.3017042910
MESH:D006973 Hypertension Raloxifene 14.3017577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 14.3018850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9017488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3616569931 16945680
MESH:D007077 Ileal Diseases Indomethacin 4.5510574470 18306037
MESH:D007079 Ileitis Indomethacin 4.8810651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9016133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.9715869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.9717600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0312013081
MESH:D007248 Infertility, Male decitabine 13.4517581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 13.4517937319
MESH:D007248 Infertility, Male Paraquat 13.454850670
MESH:D007248 Infertility, Male vinclozolin 13.4516467254
MESH:D007249 Inflammation Dexamethasone 20.298960868 11099482
MESH:D007249 Inflammation Indomethacin 20.293291741 12568917 7812673
MESH:D007249 Inflammation perfluorooctanoic acid 20.2912083418
MESH:D007249 Inflammation Progesterone 20.2915869954
MESH:D007249 Inflammation resveratrol 20.2916366677
MESH:D007249 Inflammation Tamoxifen 20.2919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.2912200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.0716624496
MESH:D007333 Insulin Resistance Estradiol 6.1616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.1616306350
MESH:D007410 Intestinal Diseases Indomethacin 3.8711713966 11686837 18236018 15831440 17329856 11855677 17994277 15610444 10210152
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.5719381132
MESH:D019586 Intracranial Hypertension Indomethacin 4.9015241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9216580747
MESH:D007579 Jejunal Diseases Indomethacin 4.5510574470 18306037 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9715604871
MESH:D007674 Kidney Diseases Acetaminophen 20.2312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 20.238314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 20.2315369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 20.2315618244
MESH:D007674 Kidney Diseases ferric nitrilotriacetate 20.2315834431 18617210
MESH:D007674 Kidney Diseases Indomethacin 20.2317190690
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.7416707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 24.2116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 24.2112371664
MESH:D007680 Kidney Neoplasms Estradiol 24.2115610895
MESH:D007680 Kidney Neoplasms ferric nitrilotriacetate 24.2118055543 9667754
MESH:D007680 Kidney Neoplasms Fluorouracil 24.2116985049
MESH:D007680 Kidney Neoplasms Tamoxifen 24.2118625569
MESH:D007889 Leiomyoma Raloxifene 4.0716973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5311703811 12228301 10320625
MESH:D007938 Leukemia arsenic trioxide 9.1515070760
MESH:D007938 Leukemia Benzene 9.1518335105 15935818 17119257 14694614
MESH:D007938 Leukemia decitabine 9.1519235587 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6816085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.3817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 12.2512421474
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 12.2514633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 12.2516572323 15631656 10785260
MESH:D007951 Leukemia, Myeloid arsenic trioxide 13.6819077051
MESH:D007951 Leukemia, Myeloid Benzene 13.6817506065
MESH:D007951 Leukemia, Myeloid decitabine 13.6817236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 7.9319850784 20471514 17050201 16968895 16467208
MESH:D015470 Leukemia, Myeloid, Acute Benzene 7.9319478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 7.9319010910 18460780 17679729 19387464 18704418 18206229
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 7.9318360721
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.9918055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.7515622746 17869043 16891316 19225113 19642359 12679006 17107899 19075265 16330433 17649720 15336539 16823087 19035177 16966277 12712474 11468182 12018890 16112521 16331271 15748426 15213294 17712046 17217047 9834237 11161223
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.7516087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9116882451
MESH:D007964 Leukocytosis Indomethacin 4.9016537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2417980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 11.398812269
MESH:D007984 Leydig Cell Tumor vinclozolin 11.3916417039
MESH:D008064 Lipidoses Tamoxifen 2.8215342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2411479899
MESH:D008103 Liver Cirrhosis Phenobarbital 2.6321047994
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 9.7916718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 9.7916595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.7914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 9.7918194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.7915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.7918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.7912878042
MESH:D008107 Liver Diseases Acetaminophen 5.7819784758 12587719 19460945 16610002 19014921 16611625 11587558 12969438
MESH:D008107 Liver Diseases Folic Acid 5.7816877991
MESH:D008107 Liver Diseases Phenobarbital 5.7819363144
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8316871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 30.102125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 30.1014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 30.1020195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 30.1017045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 30.1018709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 30.1019482888 8742319 19073162 15975961 19812893 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 30.1015890375 16377806 20007298
MESH:D008113 Liver Neoplasms resveratrol 30.1019812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 30.1016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 30.1016984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 23.678603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 23.6720377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 23.6712562636
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 23.6716842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 23.671399818 6150874 2563599 18308698 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 23.6712151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 23.677955063
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0015213294
MESH:D017563 Lung Diseases, Interstitial Benzene 4.3314698565
MESH:D008175 Lung Neoplasms Aflatoxin B1 16.3214755239
MESH:D008175 Lung Neoplasms arsenic trioxide 16.3219825857 11798837
MESH:D008175 Lung Neoplasms Benzene 16.3212562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 16.3218569708 18520028 18816296 6695378 20064080 20464547 17053015 20869020 20135361
MESH:D008175 Lung Neoplasms Dexamethasone 16.3211195469 15824018
MESH:D008175 Lung Neoplasms Doxorubicin 16.3217418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 16.3215246190
MESH:D008175 Lung Neoplasms Indomethacin 16.3211497255 11053908 16537180
MESH:D008175 Lung Neoplasms Tamoxifen 16.3218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 16.3219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3315086387
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.1917718048
MESH:D008223 Lymphoma Benzene 10.7217584886 17119257
MESH:D008223 Lymphoma decitabine 10.7219470736
MESH:D008223 Lymphoma Doxorubicin 10.7216098063
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8717088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.6217654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.6214749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1115621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.2320479100
MESH:D015674 Mammary Neoplasms, Animal Benzene 14.1312562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 14.1315688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 14.1319428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 19.5911921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 19.5915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 19.5917203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 19.5911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 19.598985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 19.5911731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.0719453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.0719453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.2316832597
MESH:D008545 Melanoma decitabine 8.7217785578 16505122
MESH:D008545 Melanoma Doxorubicin 8.7216827129
MESH:D008545 Melanoma Reactive Oxygen Species 8.7217992120
MESH:D008545 Melanoma resveratrol 8.7217992120
MESH:D008545 Melanoma Tamoxifen 8.7219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1119513568
MESH:D008654 Mesothelioma Doxorubicin 2.8617638057
MESH:D008659 Metabolic Diseases resveratrol 3.9617112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3116801185
MESH:D008881 Migraine Disorders Indomethacin 3.3411903285
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0815792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0815863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 12.3516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 12.3516757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 12.3512636206
MESH:D052016 Mucositis Doxorubicin 4.3217415656
MESH:D009101 Multiple Myeloma arsenic trioxide 23.9019549372 19417148 14977855 15949261 11468182
MESH:D009101 Multiple Myeloma Benzene 23.9017119195
MESH:D009101 Multiple Myeloma decitabine 23.9018172295
MESH:D009101 Multiple Myeloma Dexamethasone 23.9015867202 15744524 16118317
MESH:D009101 Multiple Myeloma Raloxifene 23.9016497877
MESH:D009101 Multiple Myeloma resveratrol 23.9017935668 17164350 17049120 16267019 16490592 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.4017962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0516239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.4418186108
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 10.7916882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 10.7919157545 16882708 18608210 19010910
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 10.799809623
MESH:D009203 Myocardial Infarction Doxorubicin 8.2715857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 8.2719151258
MESH:D009203 Myocardial Infarction resveratrol 8.2716456233 16317513 16525036 17015251 17125593 17188708
MESH:D017202 Myocardial Ischemia resveratrol 7.7817125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.7812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.0616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.0616411023
MESH:D009205 Myocarditis resveratrol 4.2917322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0117484760
MESH:D009232 Myxoma Raloxifene 5.0816343187
MESH:D009325 Nausea vorinostat 5.0520479100
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5216624393
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.4118259882
MESH:D009362 Neoplasm Metastasis Indomethacin 8.4116537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 13.1211141357
MESH:D009369 Neoplasms decitabine 13.1219116145 17925555 19470736
MESH:D009369 Neoplasms Fluorouracil 13.1218600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 13.1217405874
MESH:D009369 Neoplasms Trichloroethylene 13.1211911487
MESH:D009374 Neoplasms, Experimental Indomethacin 7.9015625704 10663608
MESH:D009374 Neoplasms, Experimental resveratrol 7.908985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5319196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2717289903
MESH:D009401 Nephrosis Doxorubicin 4.3116899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.9919348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.9916889571 15640375
MESH:D009410 Nerve Degeneration Paraquat 7.4516893418
MESH:D009410 Nerve Degeneration Rotenone 7.4515790535 17356569 18619942
MESH:D009421 Nervous System Malformations Estradiol 8.0016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.0014600291
MESH:D009436 Neural Tube Defects arsenic trioxide 14.8910525206
MESH:D009436 Neural Tube Defects Benzene 14.8915643154
MESH:D009436 Neural Tube Defects Folic Acid 14.8917438019
MESH:D009436 Neural Tube Defects sodium arsenate 14.8918186108 19446573 10525206 11749123
MESH:D009447 Neuroblastoma Doxorubicin 6.4415555623
MESH:D009447 Neuroblastoma Topotecan 6.4415176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.9418514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 11.9412349958
MESH:D019636 Neurodegenerative Diseases resveratrol 11.9417652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.9717929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1216436463
MESH:D009503 Neutropenia Folic Acid 4.0816322990
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.509802331
MESH:D009765 Obesity pirinixic acid 1.6920558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.696374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.8216049721 12819281
MESH:D009784 Occupational Diseases Benzene 7.8216737584 17119257 15576619 15612468 15913788 17479406 15727169 15935809 17178637
MESH:D010003 Osteoarthritis Indomethacin 3.387009135
MESH:D010018 Osteomalacia Phenobarbital 3.9017016548
MESH:D010024 Osteoporosis Raloxifene 3.1019059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 8.7817823083 15579764 17893378 15758505
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.7817513867
MESH:D012516 Osteosarcoma Doxorubicin 3.7415930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.1919769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Benzene 13.1912562636
MESH:D010051 Ovarian Neoplasms decitabine 13.1919331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 13.1919401270
MESH:D010051 Ovarian Neoplasms Progesterone 13.1916525653 17393432
MESH:D010146 Pain Acetaminophen 9.2916870215
MESH:D010146 Pain AM 251 9.2918987195
MESH:D010146 Pain Indomethacin 9.2917627676 13679232 17440234 3291741
MESH:D010149 Pain, Postoperative Indomethacin 4.2112538197 18702446
MESH:D010190 Pancreatic Neoplasms AM 251 18.0716500647
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 18.0715580305
MESH:D010190 Pancreatic Neoplasms decitabine 18.0719294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 18.0715113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 18.0716965848
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 18.0715580305
MESH:D010195 Pancreatitis Indomethacin 3.5015028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2611578682
MESH:D010235 Paraganglioma arsenic trioxide 3.7319927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2416537180
MESH:D010300 Parkinson Disease Paraquat 4.9415824117 15451049 16140633 11445065 16510128 11124998 11181820 12911755
MESH:D010300 Parkinson Disease Rotenone 4.9418191903 15451049 16140633 11445065 11535288 19232380 16412576 19114014 18619942
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.9816190885
MESH:D020734 Parkinsonian Disorders Indomethacin 8.0412349958
MESH:D020734 Parkinsonian Disorders Rotenone 8.0415574749 15927086 15795934 18197244
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2411903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7712520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6811148446
MESH:D010518 Periodontitis Indomethacin 4.4417225004
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6817638057
MESH:D011014 Pneumonia Paraquat 3.9912504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1218163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.6712371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.672563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2721297632
MESH:D047928 Premature Birth Indomethacin 4.6717000239
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 19.4617132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 19.4616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.4611222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 19.4618220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.2717616702
MESH:D011469 Prostatic Diseases vinclozolin 4.4718220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.3115572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2917292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2916644109 18247401 16289102 15754350 12479363
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.2916888761 16729912 16868541 18437689 15897917 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 3.2916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2918626508 19082440
MESH:D011471 Prostatic Neoplasms Raloxifene 3.2915731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms resveratrol 3.2916731767 17636462 15767336 17804756 17718901 17675339
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2915067354
MESH:D011471 Prostatic Neoplasms vorinostat 3.2917218635
MESH:D011472 Prostatitis vinclozolin 4.4718629315
MESH:D011507 Proteinuria Indomethacin 3.7411849393
MESH:D011537 Pruritus Ethinyl Estradiol 2.8515861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.0212752131
MESH:D011565 Psoriasis Cyclosporine 2.0516882103
MESH:D011658 Pulmonary Fibrosis Paraquat 2.7217997886 16324872
MESH:D011693 Purpura Raloxifene 5.0815770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6218286688 15538739 18722050 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 9.0117922066
MESH:D051437 Renal Insufficiency Folic Acid 9.0115728788
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1116325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.7619058328
MESH:D015427 Reperfusion Injury resveratrol 5.7615827377 17520802 16317513 16314181 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.8418379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.8411700416
MESH:D012135 Respiratory Sounds Paraquat 3.6111874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3918990726
MESH:D012162 Retinal Degeneration Paraquat 3.5216458197
MESH:D012208 Rhabdomyosarcoma decitabine 3.9719155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6818045962
MESH:D012509 Sarcoma Doxorubicin 3.5916767912 17710206 17203757 15625365 18313854 15675481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.8116646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 8.8114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3217846226
MESH:D012559 Schizophrenia Folic Acid 2.8316641680
MESH:D012640 Seizures 2,4-dinitrotoluene 4.8718551238
MESH:D012640 Seizures Phenobarbital 4.8716876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.366407741
MESH:D012871 Skin Diseases Folic Acid 3.1218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.4110029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 15.4115692506
MESH:D012878 Skin Neoplasms resveratrol 15.4115837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.418532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.4116192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1117203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 9.9816709447
MESH:D013088 Spermatocele Tamoxifen 9.9816709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.0316361298
MESH:D013119 Spinal Cord Injuries Progesterone 9.3215862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.3219457130
MESH:D013272 Stomach Diseases Dexamethasone 8.8215472012
MESH:D013272 Stomach Diseases Indomethacin 8.8210486359 15038085 10215738 10192188 17160473 16280098 17207306 17638125 16113693 15472012 16184426 18209964 18545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 11.5517007042
MESH:D013274 Stomach Neoplasms Benzene 11.5512562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 11.552093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 11.5519037991
MESH:D013274 Stomach Neoplasms Fluorouracil 11.5516951190 17498489 19015929 16424979 18567086 17522103 18396642 15786421 19084572 17172411
MESH:D013274 Stomach Neoplasms Folic Acid 11.5517171786
MESH:D013274 Stomach Neoplasms Indomethacin 11.5515609394
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 11.5517575124 12958204
MESH:D013276 Stomach Ulcer Dexamethasone 6.2115138204
MESH:D013276 Stomach Ulcer Indomethacin 6.2117654042 12077510 11595431 17627676 17657623 11523592 10423059 15138204 18193104 16252198 10878458 15104355 12787963 18299717 17895592 12498302 18726076 18237397 18181030 11906479 16169175 18431645 16934674 12500499 18209962 18087811 12467913 17135157 17977527 10750652 16631530 16755016 17918041 18543354 15255614 1323529 11729361 11145282 14567935 16397915 16150113 11595415
MESH:D020521 Stroke Folic Acid 7.7816517955
MESH:D020521 Stroke Raloxifene 7.7816837676
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0716321402
MESH:D013921 Thrombocytopenia vorinostat 4.5720479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7615669648
MESH:D013953 Thymus Neoplasms Benzene 4.4910850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 18.7219014326
MESH:D013964 Thyroid Neoplasms decitabine 18.7217967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 18.7216010429 17909728
MESH:D013964 Thyroid Neoplasms Indomethacin 18.7214736730 11352223 18791128
MESH:D013964 Thyroid Neoplasms Phenobarbital 18.721399818
MESH:D013978 Tibial Fractures Estradiol 12.1319048282
MESH:D013978 Tibial Fractures Raloxifene 12.1319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.6416280240
MESH:D014062 Tongue Neoplasms resveratrol 8.6416227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5015213294
MESH:D014456 Ulcer Indomethacin 4.4310574470 17380554
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 21.0316049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 21.0320435036 11780464 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 21.0317053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 21.0317616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 21.0317653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 21.0317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 21.038653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.8510091137
MESH:D014581 Urticaria Acetaminophen 2.5510982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.2716803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.2717473185
MESH:D014594 Uterine Neoplasms Benzene 13.5612562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.5614692618
MESH:D014594 Uterine Neoplasms resveratrol 13.5617044934
MESH:D014604 Uveal Neoplasms decitabine 4.4417785578
MESH:D014605 Uveitis Cyclosporine 10.191336536
MESH:D014605 Uveitis Dexamethasone 10.191336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1212125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.7316837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.8317678736 17334414 17638931 16364871
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.8317488730
MESH:D014839 Vomiting Indomethacin 4.2711897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 3.9717120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38194
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA451096prednisolone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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