AutismKB 2.0

Annotation Detail for DMRT2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DMRT2 ( - )
Gene Full Name: doublesex and mab-3 related transcription factor 2
Band: 9p24.3
Quick LinksEntrez ID:10655; OMIM: 604935; Uniprot ID:DMRT2_HUMAN; ENSEMBL ID: ENSG00000173253; HGNC ID: 2935
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
PSYCH
hyperactive-impulsive symptoms
Desease Name
Hyperactive-impulsive symptoms
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in decreased expression of DMRT2 mRNAaffects binding|decreases expression 20105288
C018021 cobaltous chloride cobaltous chloride results in decreased expression of DMRT2 mRNAdecreases expression 20105288
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of DMRT2 mRNAdecreases expression 18709148
D004041 Dietary Fats Dietary Fats results in decreased expression of DMRT2 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol results in decreased expression of DMRT2 mRNAdecreases expression 17823450
18709148
C041786 palm oil palm oil results in decreased expression of DMRT2 mRNAdecreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of DMRT2 mRNAdecreases expression 18709148
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in decreased expression of DMRT2 mRNAaffects binding|decreases expression 20105288
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 6.0717302879
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001943 Breast Neoplasms Cobalt 2.0915986119
MESH:D001943 Breast Neoplasms Dietary Fats 2.0920435547
MESH:D001943 Breast Neoplasms Estradiol 2.0914630087 17289903 17018787 19861407 18497071 17261762 16675129 12948864
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7816924424
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9318566989
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 4.3315059100 16823706 11298694
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.7516616286
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema perfluorooctanoic acid 3.8217259670 12083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.1319148513 11473722 18566989
MESH:D005234 Fatty Liver Dietary Fats 3.4819004024 18296743 19551842 17967931
MESH:D005355 Fibrosis Dietary Fats 3.8318296743
MESH:D006529 Hepatomegaly perfluorooctanoic acid 4.403609246
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006930 Hyperalgesia perfluorooctanoic acid 4.0412083418
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Cobalt 3.9817039479
MESH:D007249 Inflammation Dietary Fats 5.7320412841
MESH:D007249 Inflammation perfluorooctanoic acid 5.7312083418
MESH:D007333 Insulin Resistance Dietary Fats 7.8711836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.8716393666 16627594
MESH:D007674 Kidney Diseases Estradiol 2.7115618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1815610895
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.578812269
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 5.5618709148
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 5.5614757943 18709148
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 4.008603461
MESH:D008173 Lung Diseases, Obstructive Cobalt 6.176434250
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 6.9216457693
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.9211807958 17203775 11408345 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009421 Nervous System Malformations Estradiol 3.9316427766 11399458
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.269802331
MESH:D009765 Obesity Dietary Fats 2.3319632207 21332399 18674790 16723640 20518802 20132043 11836018 18457598 17217161
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 5.2916397352
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.7317132714
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011658 Pulmonary Fibrosis Cobalt 4.076434250
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved