AutismKB 2.0

Annotation Detail for KHDRBS3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:KHDRBS3 ( Etle,SALP,SLM-2,SLM2,T-STAR,TSTAR,etoile )
Gene Full Name: KH domain containing, RNA binding, signal transduction associated 3
Band: 8q24.23
Quick LinksEntrez ID:10656; OMIM: 610421; Uniprot ID:KHDR3_HUMAN; ENSEMBL ID: ENSG00000131773; HGNC ID: 18117
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KHDRBS3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KHDRBS3 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KHDRBS3 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in increased expression of KHDRBS3 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of KHDRBS3 mRNAaffects expression 17555576
C041786 palm oil palm oil results in increased expression of KHDRBS3 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KHDRBS3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of KHDRBS3 mRNAincreases expression 18301758
C017947 sodium arsenite sodium arsenite results in increased expression of KHDRBS3 mRNAincreases expression 17879257
D013629 Tamoxifen Tamoxifen affects the expression of KHDRBS3 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2217306315 16712894
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.7915238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.7911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.1520435547
MESH:D001943 Breast Neoplasms Tamoxifen 2.1520859285 19221464 19103187 19155303 17440819 18855134 19288272 19011961 21152245 19189212 17049068 18351453 19066611 16202921 19487384 19084267 20390343 19189210 20065188 20544844 18997820 15565566 18821012 18629630 16273361 19142967 21138602 15668708 19059307 20135344 19410462 11161223 17893378 20005174 17261762 19115204 16873071 18984771 16818667 17242785 19244106 18425577 18815881 19289846 19200415
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0416011737 16097048 16227642 15673190 15721981 18705752 15700767 3786805 16124888 16192424 10355542 16050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.793084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7918788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7916507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7916924424
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1219524636 20056578
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2515861022 17333356 17110522 11677210 17681005 16105132 16919318
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9114550746 11461765 11743745 12958197 12540782 16227642 19420014 19085960 11739529 19416960 16485898 16781746 18713872 17522070 10663392 16177239 19164858 14725611 12594235 11834606 19370779 11287661 17906064 14986274 16393943 16109766 12153990 10915739 2444490 12392966 19923254 12705907 17562736 18071297 11529661 19739265 10774834 16081117 15619225 11421492 15968718
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9110092053 16177239 6623471 9327722 7120509 4309450 7179309 19085960 3732212 15968718 15027814 21278145 19336974 16227642 15998439 7440962 11566570 2869522 6884620 17522070 3786805 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1717893378 20544844 16202921 19155303
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.0115959796 16239168 12631006 17595544 12795759 16045604 61145 19224547
MESH:D005234 Fatty Liver Dietary Fats 27.0119551842 18296743 17967931 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.0115345470
MESH:D005234 Fatty Liver pirinixic acid 27.0120131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 27.0119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6918705752
MESH:D005355 Fibrosis Dietary Fats 9.6918296743
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.2519176532 16221962 18467677 19772884
MESH:D006689 Hodgkin Disease sodium arsenite 3.3312676792
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0817937319
MESH:D007248 Infertility, Male sodium arsenite 7.0812646999 15346721
MESH:D007249 Inflammation Dietary Fats 5.4220412841
MESH:D007249 Inflammation Tamoxifen 5.4219457130
MESH:D007333 Insulin Resistance Dietary Fats 7.6718457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007674 Kidney Diseases Acetaminophen 6.3315629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.3320008137
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2118625569
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9717174718 16943688 17334410 11408273 16239168 17157831 21278145 11903743 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5618054572 16248980 17922224 12649538 16638106 16136751 15931870 14716496 12445418 17557913 17698563 18472094 14724832 15673190 18156304 16015684 17766677 12546737 15370692 15730626 18205269 18277467 18420326 12632514 14716833 12898905 15876570 18251166 18317297 17761835 18418968 14748882 10355542 17823541 18187930 17714472 18006644 17481882 12667390 12666154 17631135 18472332 15362042 17869086 15123356 17708605 18263696 18412020 15057751 15338365 18166357 17805973 18429990 18395914 12389079 18376398 16033810 15818738 15925388 18210741 17721639 12445421 17525996 12958196 12609069 17976157 18481824 18705752 15650968 16097048 20821823 15996030 12632512 16027843 17565644 12741479 15959796 18395095 16192424 12586293 15052691 16116963 18279442 14620537 14512876 17640975 18339082 15893842 11481614 16011737 17900296 13678700 17944888
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5618564211
MESH:D008107 Liver Diseases Acetaminophen 4.0516610002 19014921 19784758 12969438 16611625 19460945 11587558 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0516964402 15720792 16246199 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.0616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2719294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.2716377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 11.2716712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 11.2716684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7315583823 12014681
MESH:D008171 Lung Diseases sodium arsenite 3.3019095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.5417306315 17077188 16712894 15276417 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 2.5418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7411731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma sodium arsenite 3.4119082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.4112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 5.2517405874
MESH:D009369 Neoplasms sodium arsenite 5.2511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219196722 19189210 19200415
MESH:D009436 Neural Tube Defects sodium arsenite 3.2712854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Dietary Fats 4.5811836018 17217161 21332399 18674790 20518802 18457598 20132043 16723640 19632207
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4915276417 17306315
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2016039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012878 Skin Neoplasms sodium arsenite 2.7818572023 19524636
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9512854658
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.3511723127 16452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.358653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9611813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30094
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA444437Hepatitis B
    Releated drug ID Related drug Name
    PA450626nicotine
    PA450163lamivudine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved