AutismKB 2.0

Annotation Detail for CELF2


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Basic Information Top
Gene Symbol:CELF2 ( BRUNOL3,CUGBP2,ETR-3,ETR3,NAPOR )
Gene Full Name: CUGBP, Elav-like family member 2
Band: 10p14
Quick LinksEntrez ID:10659; OMIM: 602538; Uniprot ID:CELF2_HUMAN; ENSEMBL ID: ENSG00000048740; HGNC ID: 2550
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1767Immunologic deficiency syndrome
1807Autoimmune disease
1944Breast cancer
2053Colon cancer
2103Lymphoproliferative disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNAaffects cotreatment|increases expression 16054899
D003907 Dexamethasone [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNAaffects cotreatment|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNAaffects cotreatment|increases expression 16054899
C089730 rosiglitazone [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CELF2 mRNAdecreases expression 16443690
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of CELF2 mRNAaffects cotreatment|decreases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CELF2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CELF2 mRNAdecreases expression 16054899
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4715322242 14514962 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.9119621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001169 Arthritis, Experimental Dexamethasone 3.7617659584
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5616120746 18850075 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.248697196 15340226 12621046 16354765 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5415824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4317141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.7017728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7015322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.9612438553
MESH:D003920 Diabetes Mellitus rosiglitazone 4.6717446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.7512642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7517107852
MESH:D003967 Diarrhea Dexamethasone 4.207237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004485 Eczema Dexamethasone 4.9712438553
MESH:D004487 Edema Dexamethasone 14.1819703484
MESH:D004487 Edema rosiglitazone 14.1812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.1811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver rosiglitazone 4.3619196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4512621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.187520565
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia rosiglitazone 4.2412083418
MESH:D006973 Hypertension Dexamethasone 5.6617042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6618670907 18850075
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 6.1718306037
MESH:D007249 Inflammation Dexamethasone 9.518960868 11099482
MESH:D007249 Inflammation rosiglitazone 9.5112083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.5112878042 12200463
MESH:D007333 Insulin Resistance rosiglitazone 4.0416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 6.1718306037
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.8116718785
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.8117347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.8112878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Dexamethasone 2.5315824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5311884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.6316827153
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.7217261469
MESH:D009101 Multiple Myeloma Dexamethasone 3.7815867202 16118317 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.749809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.7421297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211118676 11896295 11399792 11222880
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.4818379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013272 Stomach Diseases Dexamethasone 4.9515472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.9115138204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D014605 Uveitis Dexamethasone 5.541336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27046
  • Releated gene ID Related gene Name
    PA293PTGS2
    Releated disease ID Related disease Name
    PA447197Attention Deficit Disorder with Hyperactivity
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018