Annotation Detail for CES1
Basic Information Top
| Gene Symbol: | CES1 ( ACAT,CEH,CES2,HMSE,HMSE1,MGC117365,PCE-1,SES1,TGH ) |
|---|---|
| Gene Full Name: | carboxylesterase 1 |
| Band: | 16q12.2 |
| Quick Links | Entrez ID:1066; OMIM: 114835; Uniprot ID:EST1_HUMAN; ENSEMBL ID: ENSG00000198848; HGNC ID: 1863 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C076996 | 27-hydroxycholesterol | 27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin] | decreases reaction|increases metabolic processing | 19761868 |
| C076996 | 27-hydroxycholesterol | 27-hydroxycholesterol results in decreased activity of CES1 protein | decreases activity | 19761868 |
| C028405 | 2-naphthol | CES1 protein affects the metabolism of 2-naphthol | affects metabolic processing | 12837533 |
| C045573 | 2-nitrophenol | CES1 protein affects the metabolism of 2-nitrophenol | affects metabolic processing | 12837533 |
| C009505 | 4,4'-diaminodiphenylmethane | 4,4'-diaminodiphenylmethane results in increased expression of CES1 mRNA | increases expression | 18648102 |
| C082137 | 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide | 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide results in increased expression of CES1 mRNA | increases expression | 15681896 |
| C032078 | 4-methylumbelliferyl acetate | Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] | decreases reaction|increases hydrolysis | 9311626 |
| C032078 | 4-methylumbelliferyl acetate | CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate | increases hydrolysis | 9311626 |
| C032078 | 4-methylumbelliferyl acetate | Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] | decreases reaction|increases hydrolysis | 9311626 |
| C032078 | 4-methylumbelliferyl acetate | tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] | decreases reaction|increases hydrolysis | 9311626 |
| C054268 | 4-methylumbelliferyl heptanoate | CES1 protein binds to and results in increased hydrolysis of 4-methylumbelliferyl heptanoate | affects binding|increases hydrolysis | 16282638 |
| C024836 | 4-nitrophenol | CES1 protein affects the metabolism of 4-nitrophenol | affects metabolic processing | 12837533 |
| C008642 | 4-nitrophenyl acetate | CES1 protein binds to and results in increased hydrolysis of 4-nitrophenyl acetate | affects binding|increases hydrolysis | 16282638 |
| C008642 | 4-nitrophenyl acetate | CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate | increases hydrolysis | 10518925 |
| C118008 | 4-nitrophenylacetic acid | CES1 protein results in increased hydrolysis of 4-nitrophenylacetic acid | increases hydrolysis | 11950785 |
| C033592 | 4-nitrophenyl butyrate | CES1 protein binds to and results in increased hydrolysis of 4-nitrophenyl butyrate | affects binding|increases hydrolysis | 16282638 |
| C033592 | 4-nitrophenyl butyrate | CES1 protein results in increased hydrolysis of 4-nitrophenyl butyrate | increases hydrolysis | 11950785 |
| C050014 | 4-nitrophenyl laurate | CES1 protein binds to and results in increased hydrolysis of 4-nitrophenyl laurate | affects binding|increases hydrolysis | 16282638 |
| C034106 | 4-nitrophenyloctanoate | CES1 protein results in increased metabolism of 4-nitrophenyloctanoate | increases metabolic processing | 15825828 |
| C418208 | 5'-deoxy-5-fluorocytidine | CES1 protein results in increased chemical synthesis of 5'-deoxy-5-fluorocytidine | increases chemical synthesis | 15687373 |
| C026979 | 6-O-monoacetylmorphine | 6-O-monoacetylmorphine binds to CES1 protein | affects binding | 9311626 |
| C026979 | 6-O-monoacetylmorphine | CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine | increases chemical synthesis | 8930175 9311626 |
| C026979 | 6-O-monoacetylmorphine | Cocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine] | decreases reaction|increases chemical synthesis | 8930175 |
| C037112 | 9-deoxy-delta-9-prostaglandin D2 | 9-deoxy-delta-9-prostaglandin D2 results in decreased expression of CES1 mRNA | decreases expression | 11409902 |
| D000083 | Acetanilides | CES1 protein results in increased hydrolysis of Acetanilides | increases hydrolysis | 8611161 |
| C036466 | aniracetam | CES1 protein results in increased hydrolysis of aniracetam | increases hydrolysis | 9300133 |
| D016718 | Arachidonic Acid | Arachidonic Acid results in decreased activity of CES1 protein | decreases activity | 19761868 |
| D001285 | Atropine | Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] | decreases reaction|increases hydrolysis | 9311626 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of CES1 mRNA | increases expression | 20127859 |
| C005618 | benzoylecgonine | CES1 protein results in increased chemical synthesis of benzoylecgonine | increases chemical synthesis | 9311626 |
| C018465 | bioallethrin | CES1 protein results in increased metabolism of bioallethrin | increases metabolic processing | 19249324 |
| C002842 | bioresmethrin | 27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin] | decreases reaction|increases metabolic processing | 19761868 |
| C002842 | bioresmethrin | CES1 protein results in increased hydrolysis of bioresmethrin | increases hydrolysis | 16387282 |
| C002842 | bioresmethrin | CES1 protein results in increased metabolism of bioresmethrin | increases metabolic processing | 19761868 19249324 |
| C002842 | bioresmethrin | CES1 protein results in increased hydrolysis of bioresmethrin | increases hydrolysis | 16387282 |
| C002842 | bioresmethrin | CES1 protein results in increased hydrolysis of bioresmethrin | increases hydrolysis | 16387282 |
| C002842 | bioresmethrin | CES1 protein results in increased hydrolysis of bioresmethrin | increases hydrolysis | 16387282 |
| D002083 | Butylated Hydroxyanisole | Butylated Hydroxyanisole results in increased expression of CES1 mRNA | increases expression | 18227147 |
| C110904 | capecitabine | CES1 protein results in increased hydrolysis of and results in increased activity of capecitabine | increases activity|increases hydrolysis | 15687373 |
| D002784 | Cholesterol | CES1 protein results in increased metabolism of Cholesterol | increases metabolic processing | 12773168 11015575 8049197 |
| D002784 | Cholesterol | Cholesterol results in increased expression of CES1 mRNA | increases expression | 8049197 |
| D002784 | Cholesterol | CES1 protein results in increased abundance of Cholesterol | increases abundance | 15825828 |
| C039671 | ciglitazone | ciglitazone results in decreased expression of CES1 mRNA | decreases expression | 11409902 |
| D002995 | Clofibric Acid | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CES1 mRNA | affects cotreatment|affects expression | 17602206 |
| C066444 | cocaethylene | CES1 protein results in increased chemical synthesis of cocaethylene | increases chemical synthesis | 9311626 12773168 |
| D003042 | Cocaine | CES1 protein results in increased hydrolysis of Cocaine | increases hydrolysis | 9311626 12679808 12773168 |
| D003042 | Cocaine | CES1 protein results in increased metabolism of [Cocaine co-treated with Ethanol] | affects cotreatment|increases metabolic processing | 12773168 9311626 |
| D003042 | Cocaine | Cocaine binds to CES1 protein | affects binding | 9311626 |
| D003042 | Cocaine | Cocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine] | decreases reaction|increases chemical synthesis | 8930175 |
| D003042 | Cocaine | Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] | decreases reaction|increases hydrolysis | 9311626 |
| D003042 | Cocaine | Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin] | decreases reaction|increases hydrolysis | 8930175 |
| D003474 | Curcumin | Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA] | decreases expression|decreases reaction | 18200517 |
| C037304 | cyhalothrin | CES1 protein inhibits the reaction [cyhalothrin results in increased activity of NR1I2 protein] | decreases reaction|increases activity | 19249324 |
| C037304 | cyhalothrin | CES1 protein results in increased metabolism of cyhalothrin | increases metabolic processing | 19249324 |
| C017160 | cypermethrin | CES1 protein results in increased hydrolysis of cypermethrin | increases hydrolysis | 16359636 |
| C017180 | decamethrin | CES1 protein affects the hydrolysis of decamethrin | affects hydrolysis | 18983829 |
| C017180 | decamethrin | CES1 protein inhibits the reaction [decamethrin results in increased activity of NR1I2 protein] | decreases reaction|increases activity | 19249324 |
| C017180 | decamethrin | CES1 protein results in increased metabolism of decamethrin | increases metabolic processing | 19249324 |
| C047759 | delapril | CES1 protein results in increased hydrolysis of and results in increased activity of delapril | increases activity|increases hydrolysis | 9300133 |
| D003907 | Dexamethasone | Dexamethasone results in increased expression of CES1 protein | increases expression | 10640517 |
| D003907 | Dexamethasone | Dexamethasone results in decreased expression of CES1 mRNA | decreases expression | 10640517 |
| D003907 | Dexamethasone | Dexamethasone results in decreased expression of CES1 protein | decreases expression | 10640517 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CES1 mRNA | affects cotreatment|affects expression | 17602206 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CES1 mRNA | affects cotreatment|increases expression | 18544905 |
| D004052 | Diethylnitrosamine | [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CES1 mRNA | affects cotreatment|decreases expression | 18253720 |
| D004128 | Dimethylnitrosamine | Dimethylnitrosamine results in increased expression of CES1 mRNA | increases expression | 17547211 |
| D015117 | 5,8,11,14-Eicosatetraynoic Acid | 5,8,11,14-Eicosatetraynoic Acid results in decreased expression of CES1 mRNA | decreases expression | 11409902 |
| D000431 | Ethanol | CES1 protein results in increased metabolism of [Cocaine co-treated with Ethanol] | affects cotreatment|increases metabolic processing | 12773168 9311626 |
| D005231 | Fatty Acids, Unsaturated | Fatty Acids, Unsaturated results in decreased activity of CES1 protein | decreases activity | 19761868 |
| D011345 | Fenofibrate | [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CES1 mRNA | affects cotreatment|decreases expression | 18253720 |
| C017690 | fenvalerate | CES1 protein results in increased metabolism of fenvalerate | increases metabolic processing | 19249324 |
| C056933 | fumonisin B1 | fumonisin B1 results in increased expression of CES1 mRNA | increases expression | 16221962 |
| D003932 | Heroin | CES1 protein results in decreased acetylation of Heroin | decreases acetylation | 9311626 |
| D003932 | Heroin | CES1 protein results in increased hydrolysis of Heroin | increases hydrolysis | 12773168 12679808 8930175 |
| D003932 | Heroin | Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin] | decreases reaction|increases hydrolysis | 8930175 |
| D003932 | Heroin | Heroin binds to CES1 protein | affects binding | 9311626 |
| C100236 | homatropine | CES1 protein binds to and results in increased metabolism of homatropine | affects binding|increases metabolic processing | 12679808 |
| C100236 | homatropine | homatropine binds to CES1 protein | affects binding | 12773168 |
| C065166 | imidapril | CES1 protein results in increased hydrolysis of and results in increased activity of imidapril | increases activity|increases hydrolysis | 9300133 |
| C051890 | irinotecan | CES1 mRNA results in increased susceptibility to irinotecan | increases response to substance | 15239142 |
| C051890 | irinotecan | CES1 protein results in increased hydrolysis of irinotecan | increases hydrolysis | 15100172 |
| C011890 | kojic acid | [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CES1 mRNA | affects cotreatment|increases expression | 18544905 |
| D008055 | Lipids | CES1 protein binds to and results in increased hydrolysis of Lipids | affects binding|increases hydrolysis | 16282638 |
| D008614 | Meperidine | CES1 protein results in increased hydrolysis of Meperidine | increases hydrolysis | 10381793 |
| D008614 | Meperidine | Meperidine binds to CES1 protein | affects binding | 10381793 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in decreased expression of CES1 protein | decreases expression | 10640517 |
| D008774 | Methylphenidate | CES1 protein results in increased hydrolysis of Methylphenidate | increases hydrolysis | 15082749 |
| D009270 | Naloxone | CES1 protein binds to and results in increased metabolism of Naloxone | affects binding|increases metabolic processing | 12679808 |
| D009270 | Naloxone | Naloxone binds to CES1 protein | affects binding | 12773168 |
| C014707 | nitrosobenzylmethylamine | nitrosobenzylmethylamine results in decreased expression of CES1 mRNA | decreases expression | 17616710 |
| C025589 | ochratoxin A | ochratoxin A results in decreased expression of CES1 mRNA | decreases expression | 16251485 |
| C009618 | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of CES1 protein | decreases activity | 15896444 |
| D053139 | Oseltamivir | CES1 protein affects the hydrolysis of Oseltamivir | affects hydrolysis | 18983829 |
| D010171 | Palmitoyl Coenzyme A | CES1 protein results in increased hydrolysis of Palmitoyl Coenzyme A | increases hydrolysis | 8611161 |
| D010261 | Paraoxon | Paraoxon results in decreased activity of CES1 protein | decreases activity | 11950785 |
| C084656 | paricalcitol | [Phosphorus co-treated with paricalcitol] results in increased expression of CES1 mRNA | affects cotreatment|increases expression | 17715259 |
| C023036 | perfluorooctanoic acid | perfluorooctanoic acid affects the expression of CES1 mRNA | affects expression | 18281256 |
| D026023 | Permethrin | CES1 protein affects the hydrolysis of Permethrin | affects hydrolysis | 18983829 |
| D026023 | Permethrin | CES1 protein results in increased hydrolysis of Permethrin | increases hydrolysis | 16359636 16387282 |
| D026023 | Permethrin | CES1 protein results in increased hydrolysis of Permethrin | increases hydrolysis | 16387282 |
| D026023 | Permethrin | CES1 protein results in increased hydrolysis of Permethrin | increases hydrolysis | 16387282 |
| D026023 | Permethrin | CES1 protein results in increased hydrolysis of Permethrin | increases hydrolysis | 16387282 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of CES1 protein | increases expression | 10640517 |
| D010664 | Phenylmethylsulfonyl Fluoride | Phenylmethylsulfonyl Fluoride results in decreased activity of CES1 protein | decreases activity | 11950785 |
| D010758 | Phosphorus | [Phosphorus co-treated with paricalcitol] results in increased expression of CES1 mRNA | affects cotreatment|increases expression | 17715259 |
| C006253 | pirinixic acid | pirinixic acid results in decreased expression of CES1 mRNA | decreases expression | 11409902 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of CES1 mRNA | increases expression | 17426115 16221962 20059764 |
| C006253 | pirinixic acid | PPARA protein promotes the reaction [pirinixic acid results in increased expression of CES1 mRNA] | increases expression|increases reaction | 20059764 |
| D011374 | Progesterone | Progesterone results in increased activity of CES1 protein | increases activity | 8696951 |
| D011431 | Dextropropoxyphene | Dextropropoxyphene binds to CES1 protein | affects binding | 10381793 |
| D012293 | Rifampin | Rifampin results in increased expression of CES1 protein | increases expression | 10640517 |
| C100720 | RPR 121056 | CES1 protein results in increased hydrolysis of RPR 121056 | increases hydrolysis | 15100172 |
| D012524 | Sarin | CES1 protein affects the metabolism of and results in decreased activity of Sarin | affects metabolic processing|decreases activity | 12679808 |
| D012643 | Selenium | Selenium results in increased expression of CES1 mRNA | increases expression | 19244175 |
| C002979 | selenomethylselenocysteine | selenomethylselenocysteine results in increased expression of CES1 | increases expression | 15897249 |
| D020358 | Sodium Cholate | Sodium Cholate results in increased expression of CES1 mRNA | increases expression | 9565681 |
| D012999 | Soman | CES1 protein affects the metabolism of and results in decreased activity of Soman | affects metabolic processing|decreases activity | 12679808 |
| C009374 | tabun | CES1 protein affects the metabolism of and results in decreased activity of tabun | affects metabolic processing|decreases activity | 12679808 |
| D013619 | Tacrine | Tacrine analog results in decreased activity of CES1 protein | decreases activity | 12725862 |
| D013619 | Tacrine | Tacrine binds to CES1 protein | affects binding | 12725862 |
| C069156 | temocaprilat | CES1 protein results in increased chemical synthesis of temocaprilat | increases chemical synthesis | 15908471 |
| C055603 | temocapril hydrochloride | CES1 protein results in increased hydrolysis of temocapril hydrochloride | increases hydrolysis | 15908471 9300133 |
| D014302 | Trinitrobenzenesulfonic Acid | Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA] | decreases expression|decreases reaction | 18200517 |
| D014302 | Trinitrobenzenesulfonic Acid | Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA | decreases expression | 18200517 |
| C005862 | tropacocaine | tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] | decreases reaction|increases hydrolysis | 9311626 |
| D014810 | Vitamin E | Vitamin E results in increased expression of CES1 mRNA | increases expression | 19244175 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000014 | Abnormalities, Drug-Induced | Ethanol | 6.13 | 17676605 18926900 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Phenobarbital | 6.13 | 6195326 | |
| MESH:D000138 | Acidosis | Ethanol | 3.72 | 11192467 | |
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 2.40 | 18653653 | |
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 3.66 | 20127859 20464547 | |
| MESH:D000230 | Adenocarcinoma | Dimethylnitrosamine | 3.66 | 16033868 | |
| MESH:D000236 | Adenoma | 4,4'-diaminodiphenylmethane | 15.58 | 3712494 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 15.58 | 6695378 | |
| MESH:D000236 | Adenoma | Diethylnitrosamine | 15.58 | 6695378 10737359 | |
| MESH:D000236 | Adenoma | Dimethylnitrosamine | 15.58 | 19555203 | |
| MESH:D000236 | Adenoma | Methylcholanthrene | 15.58 | 10545420 6695378 | |
| MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 12.86 | 19052882 17162532 19061943 17620307 16434500 18056438 | |
| MESH:D018248 | Adenoma, Liver Cell | Phenobarbital | 12.86 | 17620307 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 12.86 | 16434500 | |
| MESH:D000382 | Agricultural Workers' Diseases | cypermethrin | 4.16 | 16487989 | |
| MESH:D020268 | Alcohol-Induced Disorders, Nervous System | Ethanol | 4.52 | 15451040 15451039 | |
| MESH:D019973 | Alcohol-Related Disorders | Curcumin | 4.28 | 17887948 | |
| MESH:D000544 | Alzheimer Disease | 27-hydroxycholesterol | 5.55 | 14523054 20157255 | |
| MESH:D000544 | Alzheimer Disease | Curcumin | 5.55 | 15590663 | |
| MESH:D000544 | Alzheimer Disease | Tacrine | 5.55 | 12725862 | |
| MESH:D000853 | Anophthalmos | Ethanol | 4.05 | 15513904 | |
| MESH:D001008 | Anxiety Disorders | Ethanol | 3.36 | 11141031 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 3.31 | 19183758 | |
| MESH:D001169 | Arthritis, Experimental | Dexamethasone | 3.01 | 17659584 | |
| MESH:D001172 | Arthritis, Rheumatoid | marker/mechanism | |||
| MESH:D001172 | Arthritis, Rheumatoid | Curcumin | 2.50 | 16807698 | |
| MESH:D050197 | Atherosclerosis | 27-hydroxycholesterol | 15.12 | 9059518 11166758 | |
| MESH:D050197 | Atherosclerosis | Cholesterol | 15.12 | 16632123 | |
| MESH:D050197 | Atherosclerosis | Curcumin | 15.12 | 18704882 | |
| MESH:D050197 | Atherosclerosis | Methylcholanthrene | 15.12 | 11922910 | |
| MESH:D050197 | Atherosclerosis | Paraoxon | 15.12 | 16391483 | |
| MESH:D001289 | Attention Deficit Disorder with Hyperactivity | Methylphenidate | 4.86 | 17276750 16919137 10490706 | |
| MESH:D001321 | Autistic Disorder | Arachidonic Acid | 3.25 | 18582451 | |
| MESH:D001321 | Autistic Disorder | Methylphenidate | 3.25 | 18752063 16919137 19232924 | |
| MESH:D001327 | Autoimmune Diseases | Curcumin | 3.73 | 19761891 | |
| MESH:D001660 | Biliary Tract Diseases | 4,4'-diaminodiphenylmethane | 4.22 | 11289319 1440618 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 2.44 | 19483382 | |
| MESH:D020201 | Brain Hemorrhage, Traumatic | Progesterone | 4.54 | 17868700 | |
| MESH:D001930 | Brain Injuries | Progesterone | 3.50 | 15380490 15665606 15845082 | |
| MESH:D002545 | Brain Ischemia | Curcumin | 3.56 | 16770732 | |
| MESH:D001932 | Brain Neoplasms | Curcumin | 3.25 | 17596214 | |
| MESH:D001943 | Breast Neoplasms | Atropine | 4.57 | 12762645 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 4.57 | 17474063 20146248 | |
| MESH:D001943 | Breast Neoplasms | capecitabine | 4.57 | 12972520 18473752 | |
| MESH:D001943 | Breast Neoplasms | Curcumin | 4.57 | 19250217 16243823 18593918 18462866 | |
| MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 4.57 | 17474063 | |
| MESH:D001943 | Breast Neoplasms | Methylcholanthrene | 4.57 | 17474063 | |
| MESH:D001943 | Breast Neoplasms | ochratoxin A | 4.57 | 11921183 | |
| MESH:D001943 | Breast Neoplasms | Progesterone | 4.57 | 16175315 15562024 17614352 | |
| MESH:D001943 | Breast Neoplasms | selenomethylselenocysteine | 4.57 | 18855134 | |
| MESH:D002056 | Burns | Ethanol | 3.89 | 16374292 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Vitamin E | 3.17 | 16050911 | |
| MESH:D002277 | Carcinoma | Curcumin | 10.48 | 18593918 | |
| MESH:D002277 | Carcinoma | Dimethylnitrosamine | 10.48 | 19555203 | |
| MESH:D002277 | Carcinoma | Methylcholanthrene | 10.48 | 10545420 | |
| MESH:D006528 | Carcinoma, Hepatocellular | 4,4'-diaminodiphenylmethane | 5.03 | 7296757 3581430 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 5.03 | 10672840 16681979 18978308 18691550 16830150 18056438 20514400 11831363 16698587 16807293 19919837 16779866 16935385 18971187 19171122 10737359 16540662 19394651 16502159 18665156 16328049 19822196 16878318 20512989 18506893 19418558 17173139 19519916 17978847 17428255 20727157 20524982 19701751 20101231 19208518 17162532 16288022 20084675 18788625 19383236 17055752 19107877 17138121 20935162 20214788 18785209 19539802 20432363 16569478 18494052 3581430 21159647 17761372 19052882 18210153 3084413 18393292 19335982 20007298 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Ethanol | 5.03 | 15289165 15763234 18788625 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Phenobarbital | 5.03 | 20007298 17173139 1701930 6705139 20935162 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | Curcumin | 2.65 | 18414057 | |
| MESH:D002292 | Carcinoma, Renal Cell | 4,4'-diaminodiphenylmethane | 2.25 | 7296757 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 5.82 | 20419170 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Curcumin | 5.82 | 18462866 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Dimethylnitrosamine | 5.82 | 16033868 | |
| MESH:D006332 | Cardiomegaly | Ethanol | 2.95 | 19332462 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 4,4'-diaminodiphenylmethane | 7.94 | 7505956 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 7.94 | 21159647 17174075 7505956 2727394 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Methylcholanthrene | 7.94 | 16192471 | |
| MESH:D002493 | Central Nervous System Diseases | Phenobarbital | 3.49 | 4080065 | |
| MESH:D002659 | Child Development Disorders, Pervasive | Methylphenidate | 4.45 | 18752063 15319018 | |
| MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 3.01 | 19052882 | |
| MESH:D002779 | Cholestasis | 4,4'-diaminodiphenylmethane | 5.81 | 9022650 19486331 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 5.81 | 19176532 | |
| MESH:D002971 | Cleft Lip | Ethanol | 3.11 | 15513904 | |
| MESH:D002972 | Cleft Palate | Ethanol | 2.79 | 15513904 | |
| MESH:D019970 | Cocaine-Related Disorders | therapeutic | 12679808 12773168 | ||
| MESH:D019970 | Cocaine-Related Disorders | Cocaine | 10.38 | 19606084 | |
| MESH:D019970 | Cocaine-Related Disorders | Methylphenidate | 10.38 | 19462300 | |
| MESH:D003092 | Colitis | Curcumin | 11.77 | 16804969 16782535 18200517 | |
| MESH:D003092 | Colitis | Selenium | 11.77 | 17936198 | |
| MESH:D003092 | Colitis | Trinitrobenzenesulfonic Acid | 11.77 | 17991707 16804969 11698051 18200517 16867261 16782535 18023891 16474422 17936198 | |
| MESH:D003093 | Colitis, Ulcerative | Trinitrobenzenesulfonic Acid | 3.11 | 17276891 | |
| MESH:D003103 | Coloboma | Curcumin | 3.84 | 18809619 | |
| MESH:D003110 | Colonic Neoplasms | Curcumin | 4.68 | 19359593 16340194 | |
| MESH:D003110 | Colonic Neoplasms | Dexamethasone | 4.68 | 15824018 | |
| MESH:D003110 | Colonic Neoplasms | irinotecan | 4.68 | 17287894 17725105 | |
| MESH:D015179 | Colorectal Neoplasms | capecitabine | 2.95 | 18473752 18448328 | |
| MESH:D015179 | Colorectal Neoplasms | irinotecan | 2.95 | 17159606 16303861 18259882 18509181 16391804 17454858 15273666 | |
| MESH:D016510 | Corneal Neovascularization | Curcumin | 4.13 | 18497527 | |
| MESH:D003329 | Coronary Vasospasm | capecitabine | 5.06 | 17465463 | |
| MESH:D019465 | Craniofacial Abnormalities | decamethrin | 7.62 | 19861644 | |
| MESH:D019465 | Craniofacial Abnormalities | Dexamethasone | 7.62 | 17728286 | |
| MESH:D019465 | Craniofacial Abnormalities | Ethanol | 7.62 | 11198716 19302082 10194807 15451040 11873399 15513904 15451039 | |
| MESH:D019465 | Craniofacial Abnormalities | ochratoxin A | 7.62 | 20036863 | |
| MESH:D019465 | Craniofacial Abnormalities | Permethrin | 7.62 | 19861644 | |
| MESH:D019465 | Craniofacial Abnormalities | Vitamin E | 7.62 | 19769572 | |
| MESH:D003677 | Deficiency Diseases | marker/mechanism | |||
| MESH:D003715 | Dengue | 27-hydroxycholesterol | 4.90 | 19427377 | |
| MESH:D017449 | Dermatitis, Allergic Contact | 4,4'-diaminodiphenylmethane | 4.61 | 8156756 12868966 14531868 11906362 8970840 18759878 11298694 2524372 | |
| MESH:D017449 | Dermatitis, Allergic Contact | Dexamethasone | 4.61 | 12438553 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.00 | 18249437 | |
| MESH:D003877 | Dermatitis, Contact | 4,4'-diaminodiphenylmethane | 7.26 | 3621924 2952479 | |
| MESH:D003877 | Dermatitis, Contact | Permethrin | 7.26 | 14617103 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Curcumin | 3.70 | 18403477 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 3.70 | 20387270 | |
| MESH:D003928 | Diabetic Nephropathies | Curcumin | 3.34 | 18204486 | |
| MESH:D003929 | Diabetic Neuropathies | Progesterone | 3.73 | 17187935 | |
| MESH:D003967 | Diarrhea | Atropine | 6.27 | 10867622 | |
| MESH:D003967 | Diarrhea | Dexamethasone | 6.27 | 7237001 | |
| MESH:D056486 | Drug-Induced Liver Injury | 4,4'-diaminodiphenylmethane | 11.11 | 1440618 11289319 8291058 18289764 9653073 6482804 7440962 9328219 9022650 18692083 18648102 6679447 16192314 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 11.11 | 19107877 | |
| MESH:D056486 | Drug-Induced Liver Injury | Dimethylnitrosamine | 11.11 | 8172417 | |
| MESH:D056486 | Drug-Induced Liver Injury | Ethanol | 11.11 | 11566570 | |
| MESH:D056486 | Drug-Induced Liver Injury | fumonisin B1 | 11.11 | 16221962 | |
| MESH:D056486 | Drug-Induced Liver Injury | Selenium | 11.11 | 15131321 | |
| MESH:D004362 | Drug Toxicity | Heroin | 5.36 | 20406541 | |
| MESH:D004381 | Duodenal Ulcer | Atropine | 7.39 | 11595415 | |
| MESH:D004381 | Duodenal Ulcer | Curcumin | 7.39 | 17351913 | |
| MESH:D050171 | Dyslipidemias | Fenofibrate | 3.83 | 16707586 | |
| MESH:D004417 | Dyspnea | cypermethrin | 4.60 | 16487989 | |
| MESH:D004421 | Dystonia | Phenobarbital | 3.28 | 1851702 | |
| MESH:C538011 | Eales disease | Vitamin E | 3.91 | 9068938 | |
| MESH:D004485 | Eczema | Dexamethasone | 3.71 | 12438553 | |
| MESH:D004487 | Edema | Arachidonic Acid | 10.85 | 9831321 16716910 7990266 11698051 15177302 9599246 | |
| MESH:D004487 | Edema | Dexamethasone | 10.85 | 19703484 | |
| MESH:D004487 | Edema | perfluorooctanoic acid | 10.85 | 12083418 17259670 | |
| MESH:D004487 | Edema | pirinixic acid | 10.85 | 12083418 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | 27-hydroxycholesterol | 11.57 | 17410599 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | ciglitazone | 11.57 | 16844232 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Progesterone | 11.57 | 17692515 | |
| MESH:D016889 | Endometrial Neoplasms | Fenofibrate | 3.54 | 16569247 | |
| MESH:D004715 | Endometriosis | Progesterone | 3.08 | 16134523 | |
| MESH:D004831 | Epilepsies, Myoclonic | Phenobarbital | 3.35 | 3659116 | |
| MESH:D004828 | Epilepsies, Partial | Phenobarbital | 3.08 | 11558140 3922381 | |
| MESH:D004827 | Epilepsy | Phenobarbital | 2.43 | 20417680 | |
| MESH:D004832 | Epilepsy, Absence | Naloxone | 7.23 | 6254150 | |
| MESH:D004832 | Epilepsy, Absence | Phenobarbital | 7.23 | 6401628 | |
| MESH:D017029 | Epilepsy, Complex Partial | Phenobarbital | 3.49 | 7750514 | |
| MESH:D004830 | Epilepsy, Tonic-Clonic | Phenobarbital | 3.24 | 3659116 | |
| MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 4.32 | 16302075 | |
| MESH:D004938 | Esophageal Neoplasms | 4,4'-diaminodiphenylmethane | 10.76 | 3581430 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 10.76 | 16530937 | |
| MESH:D004938 | Esophageal Neoplasms | Dimethylnitrosamine | 10.76 | 17016578 | |
| MESH:D004938 | Esophageal Neoplasms | Ethanol | 10.76 | 16704527 | |
| MESH:D004938 | Esophageal Neoplasms | nitrosobenzylmethylamine | 10.76 | 15264214 16704527 15547733 15150132 16510608 16805852 15623463 15547721 15878914 | |
| MESH:D005234 | Fatty Liver | Curcumin | 13.07 | 19297423 | |
| MESH:D005234 | Fatty Liver | Diethylnitrosamine | 13.07 | 20387270 21071580 | |
| MESH:D005234 | Fatty Liver | Ethanol | 13.07 | 16409862 19236843 18620774 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 13.07 | 19236843 20131406 | |
| MESH:D005235 | Fatty Liver, Alcoholic | Ethanol | 4.87 | 17920746 | |
| MESH:D005310 | Fetal Alcohol Syndrome | Ethanol | 4.51 | 10194807 16946407 15513904 15451040 | |
| MESH:D005334 | Fever | Arachidonic Acid | 3.97 | 11852909 | |
| MESH:D005350 | Fibroma | 4,4'-diaminodiphenylmethane | 4.22 | 6705139 | |
| MESH:D005354 | Fibrosarcoma | Methylcholanthrene | 4.16 | 10962813 14633661 | |
| MESH:D005355 | Fibrosis | Curcumin | 6.80 | 18705752 | |
| MESH:D005355 | Fibrosis | Trinitrobenzenesulfonic Acid | 6.80 | 17994277 | |
| MESH:D005756 | Gastritis | Ethanol | 3.90 | 15046732 | |
| MESH:D005770 | Gastrointestinal Neoplasms | Curcumin | 3.93 | 18462866 | |
| MESH:D005909 | Glioblastoma | Curcumin | 2.93 | 17596214 | |
| MESH:D006042 | Goiter | 4,4'-diaminodiphenylmethane | 3.31 | 7505956 | |
| MESH:D006258 | Head and Neck Neoplasms | Curcumin | 3.09 | 18829502 18462866 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 5.09 | 20471113 | |
| MESH:D006330 | Heart Defects, Congenital | Vitamin E | 5.09 | 16080930 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 5.17 | 20558911 | |
| MESH:D006333 | Heart Failure | Selenium | 5.17 | 17162251 | |
| MESH:D006505 | Hepatitis | 4,4'-diaminodiphenylmethane | 7.34 | 6705139 | |
| MESH:D006505 | Hepatitis | cypermethrin | 7.34 | 16487989 | |
| MESH:D006529 | Hepatomegaly | fenvalerate | 19.19 | 15602828 | |
| MESH:D006529 | Hepatomegaly | fumonisin B1 | 19.19 | 16221962 | |
| MESH:D006529 | Hepatomegaly | perfluorooctanoic acid | 19.19 | 3609246 | |
| MESH:D006529 | Hepatomegaly | Phenobarbital | 19.19 | 16109766 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 19.19 | 18467677 19176532 19772884 16221962 | |
| MESH:D015417 | Hereditary Sensory and Motor Neuropathy | Curcumin | 4.27 | 17701891 | |
| MESH:D006548 | Hernia, Diaphragmatic | Dexamethasone | 4.79 | 7520565 | |
| MESH:D006548 | Hernia, Diaphragmatic | Vitamin E | 4.79 | 16490937 16863852 | |
| MESH:D006556 | Heroin Dependence | Heroin | 6.45 | 15986265 | |
| MESH:D019584 | Hot Flashes | Vitamin E | 3.18 | 14716179 | |
| MESH:D006930 | Hyperalgesia | Ethanol | 6.12 | 18783367 | |
| MESH:D006930 | Hyperalgesia | perfluorooctanoic acid | 6.12 | 12083418 | |
| MESH:D006937 | Hypercholesterolemia | therapeutic | 12773168 | ||
| MESH:D006937 | Hypercholesterolemia | 27-hydroxycholesterol | 11.63 | 17873880 | |
| MESH:D006937 | Hypercholesterolemia | Cholesterol | 11.63 | 16933029 | |
| MESH:D006937 | Hypercholesterolemia | Curcumin | 11.63 | 18704882 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 2.49 | 20558911 | |
| MESH:D006951 | Hyperlipoproteinemias | Fatty Acids, Unsaturated | 5.47 | 18435438 | |
| MESH:D006965 | Hyperplasia | 4,4'-diaminodiphenylmethane | 3.18 | 15034207 | |
| MESH:D006973 | Hypertension | Dexamethasone | 2.59 | 17042910 | |
| MESH:D020244 | Infarction, Middle Cerebral Artery | Progesterone | 3.64 | 15869954 | |
| MESH:D007249 | Inflammation | Arachidonic Acid | 13.83 | 9831321 15177302 17371808 | |
| MESH:D007249 | Inflammation | Curcumin | 13.83 | 17151092 18403477 16956363 | |
| MESH:D007249 | Inflammation | Dexamethasone | 13.83 | 8960868 11099482 | |
| MESH:D007249 | Inflammation | Diethylnitrosamine | 13.83 | 18785209 | |
| MESH:D007249 | Inflammation | perfluorooctanoic acid | 13.83 | 12083418 | |
| MESH:D007249 | Inflammation | Progesterone | 13.83 | 15869954 | |
| MESH:D015212 | Inflammatory Bowel Diseases | Curcumin | 5.38 | 18596194 18200517 | |
| MESH:D015212 | Inflammatory Bowel Diseases | Trinitrobenzenesulfonic Acid | 5.38 | 18200517 | |
| MESH:D007251 | Influenza, Human | Oseltamivir | 14.38 | 11043756 | |
| MESH:D007251 | Influenza, Human | Selenium | 14.38 | 16624496 | |
| MESH:D007251 | Influenza, Human | Vitamin E | 14.38 | 16624496 | |
| MESH:D007299 | Insect Bites and Stings | cyhalothrin | 24.56 | 15189238 | |
| MESH:D007299 | Insect Bites and Stings | cypermethrin | 24.56 | 15189238 | |
| MESH:D007299 | Insect Bites and Stings | decamethrin | 24.56 | 15189238 | |
| MESH:D007299 | Insect Bites and Stings | Permethrin | 24.56 | 15189238 12971516 12749493 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 2.08 | 16306350 | |
| MESH:D007410 | Intestinal Diseases | Trinitrobenzenesulfonic Acid | 3.85 | 17994277 | |
| MESH:D007414 | Intestinal Neoplasms | Curcumin | 3.53 | 10783313 | |
| MESH:D007565 | Jaundice | 4,4'-diaminodiphenylmethane | 4.22 | 9022650 8074119 | |
| MESH:D007569 | Jaw Abnormalities | Ethanol | 3.70 | 15513904 | |
| MESH:D007674 | Kidney Diseases | ochratoxin A | 4.99 | 11409539 | |
| MESH:D007674 | Kidney Diseases | Vitamin E | 4.99 | 12488133 | |
| MESH:D007676 | Kidney Failure, Chronic | Selenium | 3.18 | 16518626 | |
| MESH:D007680 | Kidney Neoplasms | 4,4'-diaminodiphenylmethane | 5.77 | 6582329 | |
| MESH:D007680 | Kidney Neoplasms | ochratoxin A | 5.77 | 16251485 | |
| MESH:D007859 | Learning Disorders | bioallethrin | 12.18 | 7589230 | |
| MESH:D007859 | Learning Disorders | Cholesterol | 12.18 | 17134702 | |
| MESH:D007859 | Learning Disorders | Ethanol | 12.18 | 15451040 | |
| MESH:D007889 | Leiomyoma | Curcumin | 3.84 | 18555241 | |
| MESH:D007938 | Leukemia | Curcumin | 5.46 | 18462866 | |
| MESH:D007938 | Leukemia | Permethrin | 5.46 | 12937054 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | Curcumin | 3.50 | 16106398 | |
| MESH:D015458 | Leukemia, T-Cell | Curcumin | 4.01 | 16106398 | |
| MESH:D007984 | Leydig Cell Tumor | perfluorooctanoic acid | 4.45 | 8812269 | |
| MESH:D017880 | Limb Deformities, Congenital | Ethanol | 3.22 | 17676605 | |
| MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 8.21 | 19638242 18407596 18522880 20032147 18665156 | |
| MESH:D008103 | Liver Cirrhosis | Ethanol | 8.21 | 15289165 | |
| MESH:D008103 | Liver Cirrhosis | Phenobarbital | 8.21 | 21047994 | |
| MESH:D008104 | Liver Cirrhosis, Alcoholic | Ethanol | 4.31 | 18295389 | |
| MESH:D008105 | Liver Cirrhosis, Biliary | 4,4'-diaminodiphenylmethane | 2.65 | 15034207 9327722 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Curcumin | 8.49 | 18705752 17355460 18006644 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Dexamethasone | 8.49 | 16718785 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Dimethylnitrosamine | 8.49 | 15383259 17881167 17201889 17203207 15571005 15723089 17666798 16603200 17640959 15138612 15086199 14659978 15492853 15161499 15763062 18210741 15081153 17196135 15864749 16570917 15099470 16544323 17348192 15298665 14568256 15591649 18237412 12925901 15842777 16627068 18371158 16169303 15067225 18567088 15479170 15744066 15339415 18637143 15942678 15793283 15733078 17198567 12918455 15798949 17465448 15577212 17719030 15369754 15366600 17534399 18095165 14643895 18364076 18629640 14709902 18239293 16042886 15504291 16270385 17724770 17036385 16009107 17432682 18672772 14726149 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Ethanol | 8.49 | 18166357 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Fenofibrate | 8.49 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 8.49 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Vitamin E | 8.49 | 16169303 | |
| MESH:D008107 | Liver Diseases | Curcumin | 7.11 | 16956363 | |
| MESH:D008107 | Liver Diseases | cypermethrin | 7.11 | 15991261 | |
| MESH:D008107 | Liver Diseases | Diethylnitrosamine | 7.11 | 17034775 | |
| MESH:D008107 | Liver Diseases | Phenobarbital | 7.11 | 19363144 | |
| MESH:D008108 | Liver Diseases, Alcoholic | Ethanol | 3.89 | 17347304 17207112 | |
| MESH:D017114 | Liver Failure, Acute | Dimethylnitrosamine | 3.72 | 17457977 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 19.23 | 21137059 20195826 | |
| MESH:D008113 | Liver Neoplasms | Clofibric Acid | 19.23 | 17602206 | |
| MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 19.23 | 19426721 19812893 19294768 19833225 12771043 18754104 21278145 21047994 2862719 20452335 21167192 19427195 18648771 18644402 20137499 16942905 15175105 15885732 19499222 2422723 19690152 10737359 12112319 19073162 19254457 20492335 19638242 19090486 19642983 19850985 20583210 20434301 21071580 19551842 19255062 9163691 19996281 20405173 20101389 20501860 18977376 20118626 18978307 19256749 | |
| MESH:D008113 | Liver Neoplasms | Dimethylnitrosamine | 19.23 | 15890375 3113478 | |
| MESH:D008113 | Liver Neoplasms | Fenofibrate | 19.23 | 18978307 | |
| MESH:D008113 | Liver Neoplasms | perfluorooctanoic acid | 19.23 | 14757943 18709148 | |
| MESH:D008113 | Liver Neoplasms | Phenobarbital | 19.23 | 15975961 19812893 8742319 21047994 19482888 19073162 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 19.23 | 15890375 16377806 20007298 | |
| MESH:D008114 | Liver Neoplasms, Experimental | 4,4'-diaminodiphenylmethane | 20.03 | 598648 6587162 1399818 3712494 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 20.03 | 3124819 18282651 19126423 19519916 18079962 19539802 18093689 18308698 18544905 19009564 18775883 16267830 19004024 9362446 17854601 2563599 16842330 17942915 18164116 18253720 17174075 21159647 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Dimethylnitrosamine | 20.03 | 1848544 6150874 15603536 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Fenofibrate | 20.03 | 18253720 18775883 | |
| MESH:D008114 | Liver Neoplasms, Experimental | kojic acid | 20.03 | 18544905 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Methylcholanthrene | 20.03 | 598648 1399818 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Phenobarbital | 20.03 | 17172636 18308698 1399818 6150874 2563599 | |
| MESH:D008171 | Lung Diseases | Vitamin E | 2.62 | 16863852 | |
| MESH:D008175 | Lung Neoplasms | 9-deoxy-delta-9-prostaglandin D2 | 12.22 | 15899809 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 12.22 | 20464547 18569708 17053015 18816296 20135361 20869020 20064080 18520028 6695378 | |
| MESH:D008175 | Lung Neoplasms | ciglitazone | 12.22 | 15899809 | |
| MESH:D008175 | Lung Neoplasms | Curcumin | 12.22 | 19359593 16243823 18462866 | |
| MESH:D008175 | Lung Neoplasms | Dexamethasone | 12.22 | 15824018 11195469 | |
| MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 12.22 | 20970405 6695378 21163286 20512841 | |
| MESH:D008175 | Lung Neoplasms | Dimethylnitrosamine | 12.22 | 16061637 11884234 19555203 | |
| MESH:D008175 | Lung Neoplasms | Methylcholanthrene | 12.22 | 9230183 15390079 1399818 21163286 7750092 6695378 20970405 16337739 16271038 10545420 20512841 11893704 17909032 | |
| MESH:D008175 | Lung Neoplasms | Vitamin E | 12.22 | 11062179 | |
| MESH:D008178 | Lupus Erythematosus, Cutaneous | Rifampin | 5.35 | 11422169 | |
| MESH:D008180 | Lupus Erythematosus, Systemic | Rifampin | 3.69 | 11422169 | |
| MESH:D008223 | Lymphoma | Curcumin | 3.00 | 18462866 | |
| MESH:D016399 | Lymphoma, T-Cell | Curcumin | 3.93 | 16173963 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | ochratoxin A | 9.91 | 11921183 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Progesterone | 9.91 | 17203775 11408345 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Selenium | 9.91 | 15318939 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | selenomethylselenocysteine | 9.91 | 15318939 | |
| MESH:D008545 | Melanoma | Curcumin | 2.29 | 18462866 17885582 | |
| MESH:D008569 | Memory Disorders | Curcumin | 7.29 | 17263510 | |
| MESH:D008569 | Memory Disorders | Ethanol | 7.29 | 18411066 15451040 | |
| MESH:D008654 | Mesothelioma | Selenium | 2.41 | 15107826 | |
| MESH:D008661 | Metabolism, Inborn Errors | marker/mechanism | |||
| MESH:D008850 | Microphthalmos | ochratoxin A | 5.04 | 20036863 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 2.57 | 16381670 | |
| MESH:D052016 | Mucositis | irinotecan | 4.23 | 17159606 | |
| MESH:D009101 | Multiple Myeloma | Curcumin | 5.62 | 19372569 | |
| MESH:D009101 | Multiple Myeloma | Dexamethasone | 5.62 | 15867202 16118317 15744524 | |
| MESH:D009134 | Muscular Atrophy, Spinal | Curcumin | 4.14 | 17962980 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 2.75 | 16239165 | |
| MESH:D009164 | Mycobacterium Infections | Rifampin | 4.76 | 18474467 | |
| MESH:D009190 | Myelodysplastic Syndromes | Dexamethasone | 3.04 | 9809623 | |
| MESH:D009203 | Myocardial Infarction | Cocaine | 4.75 | 18072171 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 4.75 | 19151258 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 2.32 | 16411023 | |
| MESH:D020191 | Myoclonic Epilepsies, Progressive | Phenobarbital | 3.69 | 17484760 | |
| MESH:D009216 | Myopia | Atropine | 4.46 | 12601066 | |
| MESH:D009361 | Neoplasm Invasiveness | Curcumin | 3.63 | 18495463 | |
| MESH:D009362 | Neoplasm Metastasis | 4,4'-diaminodiphenylmethane | 10.41 | 3581430 | |
| MESH:D009362 | Neoplasm Metastasis | capecitabine | 10.41 | 12972520 | |
| MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 10.41 | 9029167 3581430 | |
| MESH:D009362 | Neoplasm Metastasis | irinotecan | 10.41 | 18259882 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 8.23 | 11141357 | |
| MESH:D009369 | Neoplasms | capecitabine | 8.23 | 16374040 | |
| MESH:D009369 | Neoplasms | fenvalerate | 8.23 | 2895627 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 8.23 | 17405874 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | Curcumin | 3.74 | 12497104 | |
| MESH:D009423 | Nervous System Neoplasms | Curcumin | 4.83 | 18462866 | |
| MESH:D009436 | Neural Tube Defects | 4,4'-diaminodiphenylmethane | 5.88 | 6679447 | |
| MESH:D009436 | Neural Tube Defects | ochratoxin A | 5.88 | 20036863 | |
| MESH:D009447 | Neuroblastoma | irinotecan | 3.02 | 8761367 | |
| MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 2.69 | 20387270 | |
| MESH:D017599 | Neuroectodermal Tumors | irinotecan | 3.95 | 8761367 | |
| MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 4.32 | 20387270 | |
| MESH:D052556 | Niemann-Pick Disease, Type C | Cholesterol | 9.80 | 9802331 20557099 | |
| MESH:D052556 | Niemann-Pick Disease, Type C | perfluorooctanoic acid | 9.80 | 9802331 | |
| MESH:D009765 | Obesity | Curcumin | 3.69 | 19297423 | |
| MESH:D009765 | Obesity | pirinixic acid | 3.69 | 20558911 | |
| MESH:D009784 | Occupational Diseases | 4,4'-diaminodiphenylmethane | 2.73 | 4026338 6482804 | |
| MESH:D009293 | Opioid-Related Disorders | therapeutic | 12679808 | ||
| MESH:D009902 | Optic Neuritis | 4,4'-diaminodiphenylmethane | 4.22 | 3988306 | |
| MESH:D010018 | Osteomalacia | Phenobarbital | 3.58 | 17016548 | |
| MESH:D010024 | Osteoporosis | Curcumin | 2.95 | 18719352 | |
| MESH:D010051 | Ovarian Neoplasms | Curcumin | 4.01 | 19020741 18462866 | |
| MESH:D010051 | Ovarian Neoplasms | Progesterone | 4.01 | 17393432 16525653 | |
| MESH:D010190 | Pancreatic Neoplasms | Curcumin | 9.35 | 17440100 19401701 19196508 | |
| MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 9.35 | 16540662 | |
| MESH:D010190 | Pancreatic Neoplasms | Ethanol | 9.35 | 12384795 | |
| MESH:D010190 | Pancreatic Neoplasms | Phenobarbital | 9.35 | 16965848 | |
| MESH:D010195 | Pancreatitis | Trinitrobenzenesulfonic Acid | 3.49 | 17698068 | |
| MESH:D010212 | Papilloma | 4,4'-diaminodiphenylmethane | 2.73 | 7296757 | |
| MESH:D010243 | Paralysis | fenvalerate | 5.22 | 8952708 | |
| MESH:D010787 | Photosensitivity Disorders | 4,4'-diaminodiphenylmethane | 3.67 | 6228378 | |
| MESH:D010954 | Plasmacytoma | Selenium | 4.09 | 15087411 | |
| MESH:D011041 | Poisoning | Atropine | 15.06 | 18072136 17849254 | |
| MESH:D011041 | Poisoning | homatropine | 15.06 | 18072136 | |
| MESH:D011041 | Poisoning | Sarin | 15.06 | 16914529 | |
| MESH:D011041 | Poisoning | Soman | 15.06 | 16914529 | |
| MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 6.85 | 2563599 | |
| MESH:D011230 | Precancerous Conditions | Phenobarbital | 6.85 | 2563599 | |
| MESH:D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Dexamethasone | 3.05 | 21297632 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | perfluorooctanoic acid | 3.62 | 17132714 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 3.04 | 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | Curcumin | 3.04 | 12497104 18769126 18156803 10851300 15129424 18226269 11398177 | |
| MESH:D011471 | Prostatic Neoplasms | Vitamin E | 3.04 | 15084515 | |
| MESH:D011537 | Pruritus | Naloxone | 4.68 | 15861022 | |
| MESH:D019310 | Pseudolymphoma | Phenobarbital | 3.70 | 12752131 | |
| MESH:D011595 | Psychomotor Agitation | Methylphenidate | 5.54 | 18752063 | |
| MESH:D011618 | Psychotic Disorders | Cocaine | 4.22 | 16134406 | |
| MESH:D011649 | Pulmonary Alveolar Proteinosis | 27-hydroxycholesterol | 5.59 | 15466366 | |
| MESH:D011656 | Pulmonary Emphysema | Curcumin | 3.83 | 19168576 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 1.94 | 19058328 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Curcumin | 6.91 | 18379247 10666014 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Dexamethasone | 6.91 | 11700416 18379247 | |
| MESH:D012162 | Retinal Degeneration | 4,4'-diaminodiphenylmethane | 2.76 | 3692021 | |
| MESH:D012468 | Salivary Gland Neoplasms | Progesterone | 2.51 | 18045962 | |
| MESH:D012509 | Sarcoma | Curcumin | 3.43 | 18462866 | |
| MESH:D012640 | Seizures | Atropine | 12.65 | 17157343 12660363 11218047 | |
| MESH:D012640 | Seizures | Cocaine | 12.65 | 10454489 | |
| MESH:D012640 | Seizures | Ethanol | 12.65 | 9754883 | |
| MESH:D012640 | Seizures | Phenobarbital | 12.65 | 3137016 4039156 11442880 16876388 | |
| MESH:D012640 | Seizures | Soman | 12.65 | 10087439 | |
| MESH:D003294 | Seizures, Febrile | Phenobarbital | 4.04 | 6407741 | |
| MESH:D018805 | Sepsis | Curcumin | 3.42 | 18389075 | |
| MESH:D020230 | Serotonin Syndrome | Methylphenidate | 5.83 | 7854515 | |
| MESH:D012871 | Skin Diseases | Vitamin E | 2.18 | 18709164 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 1.96 | 19755658 10029692 | |
| MESH:D019082 | Smith-Lemli-Opitz Syndrome | 27-hydroxycholesterol | 5.24 | 11254748 | |
| OMIM:270800 | SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE | 27-hydroxycholesterol | 5.59 | 19812052 | |
| MESH:D013119 | Spinal Cord Injuries | Progesterone | 3.50 | 15862959 16503802 | |
| MESH:D013158 | Splenic Diseases | Dimethylnitrosamine | 4.47 | 12587719 | |
| MESH:D013272 | Stomach Diseases | Dexamethasone | 3.55 | 15472012 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 8.32 | 2093021 20155912 | |
| MESH:D013274 | Stomach Neoplasms | Butylated Hydroxyanisole | 8.32 | 3581430 1399818 | |
| MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 8.32 | 18456281 | |
| MESH:D013274 | Stomach Neoplasms | Dimethylnitrosamine | 8.32 | 16033868 | |
| MESH:D013274 | Stomach Neoplasms | Ethanol | 8.32 | 18456281 | |
| MESH:D013274 | Stomach Neoplasms | irinotecan | 8.32 | 15723263 | |
| MESH:D013274 | Stomach Neoplasms | nitrosobenzylmethylamine | 8.32 | 12958204 17575124 | |
| MESH:D013276 | Stomach Ulcer | Atropine | 11.58 | 11595415 | |
| MESH:D013276 | Stomach Ulcer | Curcumin | 11.58 | 19188055 16631530 | |
| MESH:D013276 | Stomach Ulcer | Dexamethasone | 11.58 | 15138204 | |
| MESH:D013276 | Stomach Ulcer | Ethanol | 11.58 | 17918041 9562338 11906479 17189318 9211565 16755016 | |
| MESH:D020521 | Stroke | Vitamin E | 2.88 | 16517955 | |
| MESH:D019966 | Substance-Related Disorders | Heroin | 5.66 | 20406541 | |
| MESH:D013375 | Substance Withdrawal Syndrome | Ethanol | 3.56 | 9754883 | |
| MESH:D013964 | Thyroid Neoplasms | 4,4'-diaminodiphenylmethane | 8.37 | 7505956 1399818 3712494 6587162 6582329 | |
| MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 8.37 | 7505956 | |
| MESH:D013964 | Thyroid Neoplasms | Phenobarbital | 8.37 | 1399818 | |
| MESH:D014202 | Tremor | Atropine | 9.08 | 17594079 | |
| MESH:D014202 | Tremor | fenvalerate | 9.08 | 8952708 | |
| MESH:D014376 | Tuberculosis | Rifampin | 4.23 | 18397238 15236969 | |
| MESH:D001749 | Urinary Bladder Neoplasms | 4,4'-diaminodiphenylmethane | 8.80 | 8074119 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 8.80 | 17053015 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Butylated Hydroxyanisole | 8.80 | 1399818 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Curcumin | 8.80 | 18593936 | |
| MESH:D014565 | Urogenital Neoplasms | Curcumin | 4.48 | 18462866 | |
| MESH:D014570 | Urologic Diseases | cypermethrin | 5.07 | 16487989 | |
| MESH:D014605 | Uveitis | Dexamethasone | 4.02 | 1336536 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:00983 | Drug metabolism - other enzymes |
| KEGG:01100 | Metabolic pathways |
| Releated gene ID | Related gene Name |
|---|---|
| PA107 | CES1 |
| Releated disease ID | Related disease Name |
|---|---|
| PA443937 | Drug Toxicity |
| PA444442 | Hepatitis, Toxic |
| PA445941 | Tuberculosis |
| PA446108 | Colorectal Neoplasms |
| Releated drug ID | Related drug Name |
|---|---|
| PA450112 | isoniazid |
| PA450464 | methylphenidate |
| PA450721 | oseltamivir |
| PA154410481 | prasugrel |
| PA448771 | capecitabine |
| PA128406956 | fluorouracil |
| PA450085 | irinotecan |
| PA452621 | antineoplastic agents |
| PA451737 | trandolapril |
| Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB00198 | other | Oseltamivir | Antiviral Agents;Enzyme Inhibitors |
| DB02161 | - | Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester | |
| DB02659 | - | Cholic Acid | |
| DB02944 | - | Alpha-D-Mannose | |
| DB03056 | - | 4-Piperidino-Piperidine | |
| DB03721 | - | O-Sialic Acid | |
| DB04509 | - | N-Methylnaloxonium | |
| DB04795 | - | Thenoyltrifluoroacetone | Chelating Agents |
| DB07821 | - | (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE | |
| DB08224 | - | (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL |
| Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB00328 | substrate | Indomethacin | Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Tocolytic Agents;Cardiovascular Agents;Nonsteroidal Anti-inflammatory Agents (NSAIAs);Gout Suppressants |
| DB00675 | inhibitor | Tamoxifen | Antineoplastic Agents, Hormonal;Selective Estrogen Receptor Modulators;Estrogen Antagonists;Bone Density Conservation Agents |
| DB00691 | - | Uniretic | Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors |
| DB00762 | substrate | Irinotecan | Antineoplastic Agents;Radiation-Sensitizing Agents;Parasympathomimetics;Enzyme Inhibitors;Prodrugs;Antineoplastic Agents, Phytogenic |
| DB01101 | substrate | Capecitabine | Antineoplastic Agents;Antimetabolites;Prodrugs;Antimetabolites, Antineoplastic |
| DB01393 | - | Hepaconda | Antilipemic Agents |
| DB01410 | substrate | Ciclesonide | Anti-Allergic Agents;Glucocorticoids |
| DB01432 | - | Cholestyramine | Anticholesteremic Agents;Antihyperlipidemics;Cholesterol Absorption Inhibitors |
| DB02161 | - | Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester | |
| DB03721 | - | O-Sialic Acid | |
| DB04509 | - | N-Methylnaloxonium | |
| DB06693 | inhibitor | Mevastatin | HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| No data |
| No data |