AutismKB 2.0

Annotation Detail for CXCR6


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Basic Information Top
Gene Symbol:CXCR6 ( BONZO,CD186,STRL33,TYMSTR )
Gene Full Name: chemokine (C-X-C motif) receptor 6
Band: 3p21.31
Quick LinksEntrez ID:10663; OMIM: 605163; Uniprot ID:CXCR6_HUMAN; ENSEMBL ID: ENSG00000172215; HGNC ID: 16647
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
Pathway IDPathway Name
500406Chemokine receptors bind chemokines
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1771Neurilemmoma
1804Chronic obstructive airway disease
1809HIV infection
1848Embryoma
1900Peripheral nerve sheath cancer
1930Graves' disease
2093Viremia
Desease Name
pneumocystis carinii pneumonia
HIV
INFECTION
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CXCR6 mRNAincreases expression 18648102
D017239 Paclitaxel CXCR6 mRNA results in decreased susceptibility to Paclitaxeldecreases response to substance 16322897
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 3.003712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 6.0911289319 1440618
MESH:D001859 Bone Neoplasms Paclitaxel 5.1715867366
MESH:D001943 Breast Neoplasms Paclitaxel 2.8716273361 18234424 15136595 18223236 18323546 16115903 16244791 11325840
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.417296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 3.4116313753
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.867296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.087505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.5119486331 9022650
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4518802399
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.5518759878 11906362 2524372 14531868 12868966 8970840 8156756 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.103621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.069022650 1440618 11289319 16192314 6482804 7440962 9653073 18692083 18648102 18289764 8291058 6679447 9328219
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 5.003581430
MESH:D004938 Esophageal Neoplasms Paclitaxel 5.0016481741
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 6.096705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.647505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.196705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.7015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 6.099022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.406582329
MESH:D008080 Liposarcoma Paclitaxel 5.4317353645
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4715034207 9327722
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.80598648 3712494 6587162 1399818
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.5314749477
MESH:D008545 Melanoma Paclitaxel 2.6316342250 12025231 12040289
MESH:D009101 Multiple Myeloma Paclitaxel 4.0314749477
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.473581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.4715867366
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.216679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.926482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 6.093988306
MESH:D010014 Osteolysis Paclitaxel 5.8715867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.1011161223
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.247296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.546228378
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.7817136230 17172428 16356831 16729912
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.743692021
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4518396642 18506536
MESH:D024801 Tauopathies Paclitaxel 5.7016930453
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.266582329 1399818 6587162 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.428074119
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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