AutismKB 2.0

Annotation Detail for CGRRF1


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Basic Information Top
Gene Symbol:CGRRF1 ( CGR19,RNF197 )
Gene Full Name: cell growth regulator with ring finger domain 1
Band: 14q22.2
Quick LinksEntrez ID:10668; OMIM: 606138; Uniprot ID:CGRF1_HUMAN; ENSEMBL ID: ENSG00000100532; HGNC ID: 15528
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CGRRF1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CGRRF1 mRNAaffects expression 21346803
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of CGRRF1 mRNAincreases expression 15890375
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CGRRF1 mRNAincreases expression 15890375
D000082 Acetaminophen Acetaminophen affects the expression of CGRRF1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of CGRRF1 mRNAincreases expression 15890375
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CGRRF1 mRNAaffects expression 16483693
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of CGRRF1 mRNAdecreases expression 16934159
D016572 Cyclosporine Cyclosporine results in increased expression of CGRRF1 mRNAincreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of CGRRF1 mRNAdecreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of CGRRF1 mRNAincreases expression 15890375
C419708 gefitinib gefitinib results in increased expression of CGRRF1 mRNAincreases expression 16685379
D008701 Methapyrilene Methapyrilene results in increased expression of CGRRF1 mRNAincreases expression 15890375
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of CGRRF1 mRNAincreases expression 15890375
C006253 pirinixic acid pirinixic acid results in decreased expression of CGRRF1 mRNAdecreases expression 15890375
C009250 sevoflurane sevoflurane affects the expression of CGRRF1 mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CGRRF1 mRNAincreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 2.8816033868
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 7.3016176798
MESH:D000236 Adenoma Dimethylnitrosamine 7.3019555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8716835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.4615469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.0220146248
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0217129689 15324884
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002277 Carcinoma Dimethylnitrosamine 8.3019555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.843084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.8421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.8416924424 15948411
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 3.9418347146 16230376 20005069 17290066 15496427 19233551
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 2.9416033868
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.526135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Cyclosporine 7.7019486331
MESH:D002779 Cholestasis pirinixic acid 7.7019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.098697196 16354765 15340226 12621046 15668235
MESH:D015179 Colorectal Neoplasms gefitinib 3.2417594712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5412952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.8518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.8518551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.2018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.2021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.2011461765 14725611 14550746 16781746 10663392 17522070 19416960 11421492 19739265 12958197 12153990 12705907 12540782 10915739 11529661 17906064 15968718 14986274 16485898 18071297 12392966 11287661 2444490 11834606 12594235 16227642 15619225 19923254 16081117 19164858 16393943 11739529 18713872 11743745 17562736 16177239 16109766 10774834 19370779 19085960 19420014
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 15.2017851650
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 15.208172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.2020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9015322242 18230668 16714409
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.6816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.4515700306 16804899
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 2.9017016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Cyclosporine 7.5019224547
MESH:D005234 Fatty Liver pirinixic acid 7.5019236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6416002989 16534752 15751030 16513791 16611131
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Cyclosporine 8.4412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4420067830
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.9416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.2219772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2212621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0515340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4214722030 12960047
MESH:D006973 Hypertension Cyclosporine 4.9210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9218670907 18850075
MESH:D006976 Hypertension, Pulmonary gefitinib 4.6818424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 6.2318424623
MESH:D007021 Hypospadias Diethylstilbestrol 4.5716002989
MESH:D007246 Infertility Diethylstilbestrol 4.3415036965
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8412878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.7515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.7518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.1816705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 23.1816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 23.1812371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 23.1814681315 15003126 16762066
MESH:D007680 Kidney Neoplasms gefitinib 23.1818625569
MESH:D007859 Learning Disorders Diethylstilbestrol 9.9517184923
MESH:D007859 Learning Disorders sevoflurane 9.9519212262
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.4714726149 16570917 14709902 15744066 15864749 15081153 17201889 17203207 17348192 18371158 14568256 18210741 15942678 18364076 15383259 17666798 16042886 15793283 18672772 15723089 17465448 15138612 15369754 15763062 15067225 15591649 15479170 12925901 18637143 15504291 15161499 18095165 15798949 18629640 17724770 15086199 15577212 18237412 16627068 17719030 17534399 15492853 18239293 16544323 14643895 15099470 16169303 16270385 15571005 15366600 18567088 15733078 17198567 17432682 16009107 15339415 17196135 14659978 17640959 16603200 15298665 15842777 17881167 17036385 12918455
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6219784758 12587719 19460945 16611625 12969438 16610002 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6116871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.6117457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 34.467678174
MESH:D008113 Liver Neoplasms 2-nitrofluorene 34.4615890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 34.4615890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 34.469163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Diethylstilbestrol 34.4615890375 16712894
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 34.4615890375 3113478
MESH:D008113 Liver Neoplasms Methapyrilene 34.4615890375
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 34.4619690152 18648771 20101389 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 34.4615890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 34.4616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.042876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.048603461
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 14.046150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.0412151625
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4.9012438228 19931552 16401635 15893417 15172992 18508827 18813816 16061637 14755239 17139156 9255578
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9014755239
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 4.9016061637 19555203 11884234
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9019555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.1415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4615700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5216002989
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 4.1118375820
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008569 Memory Disorders sevoflurane 4.7319212262
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.327678174 18551238
MESH:D009369 Neoplasms Diethylstilbestrol 5.0015313581
MESH:D009369 Neoplasms pirinixic acid 5.0017405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2718481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.5911399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.8216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.8216049721
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 3.4312384795
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.1714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.6616977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.5417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5411399792 11896295 11118676 11222880
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.9117136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms gefitinib 3.9116685379 17914592 15651060
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011658 Pulmonary Fibrosis gefitinib 4.0018424623
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8218551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.7116709447 16002989
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.2712587719
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.4516033868
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms gefitinib 4.4516940797
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3016049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.3016712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.9610091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.0116175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.1714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.0516690809 15809267
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4216513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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