Annotation Detail for CGREF1
Basic Information Top
| Gene Symbol: | CGREF1 ( CGR11 ) |
|---|---|
| Gene Full Name: | cell growth regulator with EF-hand domain 1 |
| Band: | 2p23.3 |
| Quick Links | Entrez ID:10669; OMIM: 606137; Uniprot ID:CGRE1_HUMAN; ENSEMBL ID: ENSG00000138028; HGNC ID: 16962 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C019499 | 2-nitrofluorene | 2-nitrofluorene results in increased expression of CGREF1 mRNA | increases expression | 15890375 14600272 |
| C472791 | 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid | 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CGREF1 mRNA | increases expression | 16788091 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CGREF1 mRNA | increases expression | 14600272 15890375 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of CGREF1 mRNA | affects expression | 17562736 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in increased expression of CGREF1 mRNA | increases expression | 14600272 15890375 |
| C000188 | alachlor | alachlor results in increased expression of CGREF1 mRNA | increases expression | 12419858 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of CGREF1 mRNA | affects expression | 16483693 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of CGREF1 mRNA | decreases expression | 20064835 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of CGREF1 mRNA | increases expression | 17484886 |
| D004041 | Dietary Fats | Dietary Fats results in increased expression of CGREF1 mRNA | increases expression | 18457598 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased expression of CGREF1 mRNA | increases expression | 17005392 15890375 |
| D004128 | Dimethylnitrosamine | Dimethylnitrosamine results in increased expression of CGREF1 mRNA | increases expression | 14600272 15890375 |
| D005419 | Flavonoids | Flavonoids results in decreased expression of CGREF1 mRNA | decreases expression | 18035473 |
| D008701 | Methapyrilene | Methapyrilene results in increased expression of CGREF1 mRNA | increases expression | 15890375 |
| D010882 | Piperonyl Butoxide | Piperonyl Butoxide results in increased expression of CGREF1 mRNA | increases expression | 15890375 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of CGREF1 mRNA | increases expression | 18301758 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of CGREF1 mRNA | increases expression | 15890375 |
| D014415 | Tunicamycin | Tunicamycin results in decreased expression of CGREF1 mRNA | decreases expression | 17127020 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 3.55 | 18287403 | |
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 3.10 | 18653653 | |
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 4.55 | 20127859 20464547 | |
| MESH:D000230 | Adenocarcinoma | Dimethylnitrosamine | 4.55 | 16033868 | |
| MESH:D000236 | Adenoma | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 11.31 | 16176798 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 11.31 | 6695378 | |
| MESH:D000236 | Adenoma | Dimethylnitrosamine | 11.31 | 19555203 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 3.47 | 16434500 | |
| MESH:D000382 | Agricultural Workers' Diseases | alachlor | 4.65 | 14769641 11874814 | |
| MESH:D000686 | Amyloidosis | Diethylstilbestrol | 4.46 | 15469931 | |
| MESH:D000799 | Angioedema | Acetaminophen | 3.84 | 10982225 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 4.06 | 19183758 | |
| MESH:D001161 | Arteriosclerosis | Dietary Fats | 3.87 | 15238619 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.42 | 18445737 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 3.13 | 19483382 | |
| MESH:D001943 | Breast Neoplasms | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 2.02 | 20146248 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 2.02 | 17474063 20146248 | |
| MESH:D001943 | Breast Neoplasms | Dietary Fats | 2.02 | 20435547 | |
| MESH:D001943 | Breast Neoplasms | Diethylstilbestrol | 2.02 | 15324884 17129689 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 3.77 | 15721981 16011737 15700767 16097048 16050911 16192424 15673190 18705752 16227642 3786805 16124888 10355542 | |
| MESH:D002277 | Carcinoma | Dimethylnitrosamine | 4.00 | 19555203 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 6.56 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Aflatoxin B1 | 6.56 | 12907637 21507988 12619106 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 6.56 | 18788625 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylstilbestrol | 6.56 | 15948411 16924424 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 4.79 | 20419170 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Dimethylnitrosamine | 4.79 | 16033868 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.57 | 10977129 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 2.81 | 19176532 | |
| MESH:D003456 | Cryptorchidism | Diethylstilbestrol | 4.54 | 12952375 16002989 | |
| MESH:D017449 | Dermatitis, Allergic Contact | alachlor | 4.17 | 8428444 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.41 | 18249437 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 6.25 | 12594235 19739265 19164858 19085960 14550746 16081117 12540782 11743745 12153990 12705907 16393943 11461765 16485898 18071297 11529661 19416960 19923254 16781746 17562736 18713872 19370779 14725611 10774834 15968718 2444490 11739529 10663392 11287661 12392966 16109766 12958197 16177239 14986274 17906064 11834606 10915739 19420014 16227642 15619225 17522070 11421492 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 6.25 | 7440962 21278145 4309450 15027814 19085960 10092053 19336974 10915739 9327722 6623471 16177239 7120509 11566570 15998439 15968718 3786805 2869522 7179309 16227642 6884620 17522070 3732212 | |
| MESH:D056486 | Drug-Induced Liver Injury | Dimethylnitrosamine | 6.25 | 8172417 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 4.10 | 19426721 | |
| MESH:D050171 | Dyslipidemias | Dietary Fats | 3.44 | 18367378 | |
| MESH:D004487 | Edema | pirinixic acid | 2.46 | 12083418 | |
| MESH:D004714 | Endometrial Hyperplasia | Diethylstilbestrol | 4.68 | 16402032 | |
| MESH:D016889 | Endometrial Neoplasms | Diethylstilbestrol | 3.45 | 15700306 16804899 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 4.64 | 16530937 | |
| MESH:D004938 | Esophageal Neoplasms | Dimethylnitrosamine | 4.64 | 17016578 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 12.99 | 15959796 61145 16239168 19224547 12631006 12795759 17595544 16045604 | |
| MESH:D005234 | Fatty Liver | Dietary Fats | 12.99 | 17967931 18296743 19551842 19004024 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 12.99 | 19236843 20131406 | |
| MESH:D052776 | Female Urogenital Diseases | Diethylstilbestrol | 3.64 | 16513791 16534752 15751030 16611131 16002989 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 8.76 | 18705752 | |
| MESH:D005355 | Fibrosis | Dietary Fats | 8.76 | 18296743 | |
| MESH:D005756 | Gastritis | Acetaminophen | 3.68 | 16983495 | |
| MESH:D005833 | Genital Neoplasms, Female | Diethylstilbestrol | 4.94 | 16452187 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 2.64 | 20471113 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 2.52 | 20558911 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 3.58 | 19900420 19110552 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 2.98 | 18467677 16221962 19772884 19176532 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 2.68 | 16870215 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 4.52 | 16899240 | |
| MESH:D006937 | Hypercholesterolemia | Dietary Fats | 3.57 | 21332399 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 3.16 | 20558911 | |
| MESH:D006949 | Hyperlipidemias | Dietary Fats | 3.60 | 21332399 | |
| MESH:D006965 | Hyperplasia | Diethylstilbestrol | 4.42 | 12960047 14722030 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 4.07 | 15338365 | |
| MESH:D007021 | Hypospadias | Diethylstilbestrol | 4.57 | 16002989 | |
| MESH:D007246 | Infertility | Diethylstilbestrol | 4.34 | 15036965 | |
| MESH:D007248 | Infertility, Male | alachlor | 4.13 | 16466525 17049205 12948887 | |
| MESH:D007249 | Inflammation | Dietary Fats | 5.17 | 20412841 | |
| MESH:D007249 | Inflammation | Flavonoids | 5.17 | 17296493 | |
| MESH:D007333 | Insulin Resistance | Dietary Fats | 7.20 | 18457598 11836018 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 7.20 | 16306350 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.19 | 15629191 12587719 | |
| MESH:D007680 | Kidney Neoplasms | Diethylstilbestrol | 3.44 | 15003126 16762066 14681315 | |
| MESH:D007859 | Learning Disorders | Diethylstilbestrol | 4.05 | 17184923 | |
| MESH:D007938 | Leukemia | alachlor | 4.00 | 14769641 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 6.59 | 16943688 17157831 11408273 11903743 21278145 16221502 17174718 16239168 17334410 | |
| MESH:D008103 | Liver Cirrhosis | Dietary Fats | 6.59 | 18296743 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 3.54 | 18054572 14724832 14748882 18279442 15338365 18418968 18251166 18210741 18376398 15362042 12445418 18156304 16015684 13678700 18412020 15876570 17714472 15893842 18277467 17766677 17805973 17721639 14716496 18205269 17823541 11481614 12666154 17557913 17708605 16192424 15818738 15123356 17761835 12632514 18472332 15730626 17922224 17525996 18420326 15650968 18006644 16116963 14512876 18429990 17698563 20821823 17900296 12632512 18472094 18187930 15931870 15057751 12649538 12586293 14716833 17565644 16638106 16248980 18263696 18395914 15959796 12898905 12609069 12741479 16033810 15673190 16136751 18317297 14620537 18166357 16011737 10355542 16097048 17640975 18395095 17631135 17481882 15996030 17869086 16027843 15052691 12667390 17976157 18481824 12389079 12958196 15370692 12546737 15925388 18339082 18705752 12445421 17944888 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Dimethylnitrosamine | 3.54 | 15798949 14726149 15339415 18364076 15161499 17724770 18637143 15383259 18567088 15723089 15366600 16009107 12918455 16603200 15733078 18095165 16270385 17432682 12925901 15793283 15842777 18239293 17534399 15591649 18371158 16169303 17640959 16627068 15942678 16570917 16042886 14643895 15086199 15571005 17036385 17198567 15067225 15744066 15138612 17719030 17465448 15369754 15298665 15504291 15479170 15081153 15099470 15763062 16544323 18629640 14659978 17203207 17666798 14568256 18237412 17201889 17196135 15577212 18210741 18672772 17348192 17881167 14709902 15864749 15492853 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 3.54 | 15474484 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 3.88 | 16611625 19460945 11587558 12587719 12969438 16610002 19014921 19784758 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 3.88 | 16964402 17285989 15720792 15830285 16246199 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 4.15 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 16.16 | 16871587 17185352 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 16.16 | 14706259 16899240 | |
| MESH:D017114 | Liver Failure, Acute | Dimethylnitrosamine | 16.16 | 17457977 | |
| MESH:D008113 | Liver Neoplasms | 2-nitrofluorene | 34.46 | 15890375 | |
| MESH:D008113 | Liver Neoplasms | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 34.46 | 15890375 | |
| MESH:D008113 | Liver Neoplasms | Aflatoxin B1 | 34.46 | 15890375 18177683 9163691 2125692 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 34.46 | 21137059 20195826 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 34.46 | 19294768 | |
| MESH:D008113 | Liver Neoplasms | Diethylstilbestrol | 34.46 | 16712894 15890375 | |
| MESH:D008113 | Liver Neoplasms | Dimethylnitrosamine | 34.46 | 15890375 3113478 | |
| MESH:D008113 | Liver Neoplasms | Methapyrilene | 34.46 | 15890375 | |
| MESH:D008113 | Liver Neoplasms | Piperonyl Butoxide | 34.46 | 18648771 19690152 15890375 20101389 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 34.46 | 16377806 15890375 20007298 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Aflatoxin B1 | 9.90 | 8603461 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 9.90 | 15583823 12014681 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Dimethylnitrosamine | 9.90 | 15603536 1848544 6150874 | |
| MESH:D008175 | Lung Neoplasms | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 4.92 | 17139156 18508827 16061637 14755239 15172992 12438228 16401635 15893417 9255578 19931552 18813816 | |
| MESH:D008175 | Lung Neoplasms | Aflatoxin B1 | 4.92 | 14755239 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 4.92 | 20135361 18520028 6695378 17053015 18816296 20064080 18569708 20869020 20464547 | |
| MESH:D008175 | Lung Neoplasms | Dimethylnitrosamine | 4.92 | 11884234 19555203 16061637 | |
| MESH:D008181 | Lupus Nephritis | Diethylstilbestrol | 5.14 | 15166399 | |
| MESH:D008223 | Lymphoma | Diethylstilbestrol | 3.46 | 15700306 | |
| MESH:D052801 | Male Urogenital Diseases | Diethylstilbestrol | 5.52 | 16002989 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 3.55 | 19513568 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 3.17 | 16381670 | |
| MESH:D009101 | Multiple Myeloma | alachlor | 4.27 | 14769641 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 3.49 | 16239165 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 2.13 | 19151258 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 2.93 | 16411023 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 8.18 | 11141357 | |
| MESH:D009369 | Neoplasms | Diethylstilbestrol | 8.18 | 15313581 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 8.18 | 17405874 | |
| MESH:D009421 | Nervous System Malformations | Diethylstilbestrol | 4.12 | 11399458 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 2.85 | 18514411 | |
| MESH:D009669 | Nose Neoplasms | alachlor | 4.81 | 14563481 15580706 16698726 11127290 16178123 | |
| MESH:D009765 | Obesity | Dietary Fats | 4.42 | 21332399 20132043 17217161 19632207 18674790 18457598 11836018 16723640 20518802 | |
| MESH:D009765 | Obesity | pirinixic acid | 4.42 | 20558911 | |
| MESH:D010146 | Pain | Acetaminophen | 2.37 | 16870215 | |
| MESH:D010190 | Pancreatic Neoplasms | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 3.43 | 12384795 | |
| MESH:D010900 | Pituitary Diseases | Diethylstilbestrol | 5.17 | 14722030 | |
| MESH:D010911 | Pituitary Neoplasms | Diethylstilbestrol | 4.66 | 15687265 16977796 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Diethylstilbestrol | 4.10 | 17184923 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 3.29 | 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | Diethylstilbestrol | 3.29 | 15046698 17136230 15846301 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 2.38 | 19058328 | |
| MESH:D012135 | Respiratory Sounds | alachlor | 4.93 | 11874814 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 2.36 | 19755658 10029692 | |
| MESH:D013088 | Spermatocele | Diethylstilbestrol | 4.71 | 16002989 16709447 | |
| MESH:D013158 | Splenic Diseases | Dimethylnitrosamine | 5.27 | 12587719 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 2.58 | 20155912 2093021 | |
| MESH:D013274 | Stomach Neoplasms | Dimethylnitrosamine | 2.58 | 16033868 | |
| MESH:D013964 | Thyroid Neoplasms | alachlor | 4.25 | 8812207 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 5.12 | 17053015 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Diethylstilbestrol | 5.12 | 16712894 17306315 16452187 | |
| MESH:D014581 | Urticaria | Acetaminophen | 2.96 | 10982225 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Diethylstilbestrol | 4.01 | 16175088 | |
| MESH:D014591 | Uterine Diseases | Diethylstilbestrol | 5.17 | 14652134 | |
| MESH:D014594 | Uterine Neoplasms | Diethylstilbestrol | 4.05 | 16690809 15809267 | |
| MESH:D014625 | Vaginal Neoplasms | Diethylstilbestrol | 4.42 | 16513791 16002989 | |
| MESH:D015430 | Weight Gain | Dietary Fats | 3.72 | 16723640 |
| No data |