AutismKB 2.0

Annotation Detail for AVIL


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Basic Information Top
Gene Symbol:AVIL ( ADVIL,DKFZp779O1812,DOC6,FLJ12386,MGC133244,p92 )
Gene Full Name: advillin
Band: 12q14.1
Quick LinksEntrez ID:10677; OMIM: 613397; Uniprot ID:AVIL_HUMAN; ENSEMBL ID: ENSG00000135407; HGNC ID: 14188
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AVIL mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of AVIL mRNAincreases expression 20458559
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of AVIL mRNAaffects cotreatment|decreases expression 18164116
D004041 Dietary Fats Dietary Fats results in decreased expression of AVIL mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of AVIL mRNAaffects cotreatment|decreases expression 18164116
D005419 Flavonoids Flavonoids results in decreased expression of AVIL mRNAdecreases expression 18035473
C041786 palm oil palm oil results in decreased expression of AVIL mRNAdecreases expression 18042831
C025299 polyphenols polyphenols results in decreased expression of AVIL mRNAdecreases expression 16293270
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of AVIL mRNAdecreases expression 11007951
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3311798837 19825857
MESH:D000236 Adenoma beta-Naphthoflavone 7.2519389873
MESH:D000236 Adenoma Diethylnitrosamine 7.256695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0317620307 19052882 19061943 16434500 17162532 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.8320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1411135700 16217749 15073043 15553829 14691202
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.143581430 19052882 19394651 20007298 19335982 17173139 19383236 18210153 19107877 3084413 16698587 20214788 17428255 16288022 18494052 19822196 20935162 16779866 16540662 16935385 16830150 17978847 20101231 19539802 18785209 20524982 16807293 18393292 20512989 20727157 18978308 11831363 19519916 19701751 17162532 17761372 20084675 16569478 17055752 21159647 18691550 19171122 18056438 17138121 16502159 18506893 10672840 20514400 19418558 16328049 10737359 20432363 18788625 16681979 19919837 18665156 18971187 19208518 16878318
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9917174075 7505956 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 15340226 15668235 8697196 16354765
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 15322242 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5919107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.5919370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3512903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 14.4115073043
MESH:D005234 Fatty Liver Dietary Fats 14.4119551842 18296743 17967931 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 14.4120387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Dietary Fats 9.5018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3618606429 16354765 8697196 16959395 15340226
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007249 Inflammation Dietary Fats 16.9520412841
MESH:D007249 Inflammation Diethylnitrosamine 16.9518785209
MESH:D007249 Inflammation Flavonoids 16.9517296493
MESH:D007249 Inflammation polyphenols 16.9516366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 16.9512878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.2318457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1617050201 19850784 20471514 16968895 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3412679006 19642359 19075265 15748426 17869043 16330433 15622746 16331271 16891316 19225113 15213294 16112521 9834237 12018890 16823087 19035177 17107899 16966277 17649720 11468182 12712474 17217047 17712046 11161223 15336539
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9819638242 18522880 18665156 20032147 18407596
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.4817034775
MESH:D008107 Liver Diseases polyphenols 4.4816698588
MESH:D008113 Liver Neoplasms arsenic trioxide 11.2914682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.2919389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2919499222 19090486 19638242 18978307 20452335 19254457 19812893 20501860 19073162 2422723 19427195 19551842 18754104 2862719 20137499 20118626 19294768 20101389 19426721 19642983 12771043 21071580 18648771 15175105 18644402 9163691 18977376 19833225 19690152 15885732 12112319 19850985 16942905 19256749 21278145 21167192 19996281 19255062 20434301 21047994 20405173 20583210 10737359 20492335
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2916984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.1620377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 15.1618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.1616267830 18079962 2563599 18544905 19539802 19126423 17174075 18164116 9362446 18775883 19009564 17942915 19004024 18282651 21159647 18093689 19519916 18308698 18253720 17854601 3124819 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.1612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4911798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.496695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4919555203 11884234
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2511468182 19417148 19549372 14977855 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516105982 16882451
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.649029167 3581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity Dietary Fats 2.3319632207 21332399 18674790 18457598 20132043 17217161 20518802 16723640 11836018
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4612452020 16624393 19769630
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4915580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4916540662
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2419131511
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4817007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4818456281
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5717997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.7219014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.727505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5512973940 12845720 20435036 11780464
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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