AutismKB 2.0

Annotation Detail for GNB5


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Basic Information Top
Gene Symbol:GNB5 ( FLJ37457,FLJ43714,GB5 )
Gene Full Name: guanine nucleotide binding protein (G protein), beta 5
Band: 15q21.2
Quick LinksEntrez ID:10681; OMIM: 604447; Uniprot ID:GBB5_HUMAN; ENSEMBL ID: ENSG00000069966; HGNC ID: 4401
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Diabetes pathways
Transmembrane transport of small molecules
Hemostasis
Opioid Signalling
Integration of energy metabolism
Pathway IDPathway Name
200139Visual signal transduction: Rods
200069Thromboxane A2 receptor signaling
200078Visual signal transduction: Cones
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P04379Beta3 adrenergic receptor signaling pathway
P04377Beta1 adrenergic receptor signaling pathway
P00028Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P04386Histamine H2 receptor mediated signaling pathway
P04380Cortocotropin releasing factor receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P043765HT4 type receptor mediated signaling pathway
P00048PI3 kinase pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P043735HT1 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GNB5 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNB5 mRNAaffects expression 16483693
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of GNB5 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of GNB5 mRNAaffects cotreatment|increases expression 18585445
D001464 Barium [GNB5 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GNB5 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GNB5 mRNAaffects expression 17484886
D003976 Diazinon Diazinon affects the expression of GNB5 mRNAaffects expression 17452286
D004041 Dietary Fats Dietary Fats results in decreased expression of GNB5 mRNAdecreases expression 18503570
D007657 Ketone Bodies Ketone Bodies results in increased expression of GNB5 mRNAincreases expression 16807920
C001478 N(6)-(delta(2)-isopentenyl)adenine N(6)-(delta(2)-isopentenyl)adenine results in decreased expression of GNB5 mRNAdecreases expression 16129123
C009250 sevoflurane sevoflurane affects the expression of GNB5 mRNAaffects expression 15967596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000382 Agricultural Workers' Diseases Atrazine 9.6511874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.6516487989
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001943 Breast Neoplasms Dietary Fats 2.2720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9215700767 3786805 16227642 16097048 15673190 16124888 15721981 16050911 10355542 16192424 16011737 18705752
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0316705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0318788625
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.986623471 9327722 19336974 21278145 7179309 16177239 15027814 10915739 6884620 17522070 10092053 7440962 15998439 2869522 11566570 15968718 16227642 19085960 3786805 4309450 3732212 7120509
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004417 Dyspnea Diazinon 4.9716487989
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2217595544 15959796 16239168 12795759 16045604 12631006 61145 19224547
MESH:D005234 Fatty Liver Dietary Fats 8.2219551842 17967931 19004024 18296743
MESH:D005355 Fibrosis Carbon Tetrachloride 9.2818705752
MESH:D005355 Fibrosis Dietary Fats 9.2818296743
MESH:D006505 Hepatitis Carbon Tetrachloride 10.0419900420 19110552
MESH:D006505 Hepatitis Diazinon 10.0416487989
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007248 Infertility, Male Atrazine 7.6412948887
MESH:D007248 Infertility, Male Diazinon 7.6416466525 12948887
MESH:D007249 Inflammation Dietary Fats 2.4820412841
MESH:D007333 Insulin Resistance Dietary Fats 3.1711836018 18457598
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0616705839
MESH:D007859 Learning Disorders sevoflurane 4.9119212262
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8216943688 21278145 17157831 16239168 16221502 11903743 11408273 17334410 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518187930 16638106 12632512 12389079 15818738 17922224 18251166 14620537 17631135 14716496 17714472 16015684 18412020 17557913 18395914 17481882 16192424 12632514 18376398 12898905 12609069 18472332 18205269 17869086 18395095 14512876 18156304 16136751 18263696 14748882 15057751 17708605 14724832 18472094 15123356 18006644 12586293 12546737 16033810 15730626 14716833 18210741 17565644 12649538 18166357 16248980 12741479 17823541 18429990 15925388 17944888 12666154 11481614 17761835 15052691 15673190 16027843 17698563 15876570 15338365 12958196 17805973 18339082 15931870 18420326 12445418 12445421 18277467 15959796 15370692 15650968 16116963 18317297 13678700 16011737 18481824 17721639 15893842 15996030 17900296 10355542 17976157 18705752 15362042 12667390 16097048 18418968 18054572 18279442 17766677 17525996 17640975 20821823
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016964402 16246199 17285989 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7916899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2619294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6812014681 15583823
MESH:D008569 Memory Disorders sevoflurane 4.8719212262
MESH:D008654 Mesothelioma Atrazine 3.561916698
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009765 Obesity Dietary Fats 2.3121332399 16723640 17217161 20132043 20518802 18457598 19632207 11836018 18674790
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5312819281 16049721
MESH:D010300 Parkinson Disease Atrazine 3.3117218051
MESH:D011041 Poisoning Diazinon 4.4717603234
MESH:D012135 Respiratory Sounds Atrazine 4.6511874814
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6018551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.748532709
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3216049721
MESH:D014570 Urologic Diseases Diazinon 5.4516487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:04724 Glutamatergic synapse
REACT:604 Hemostasis
REACT:1505 Integration of energy metabolism
REACT:15295 Opioid Signalling
REACT:14797 Signaling by GPCR
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28780
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    PA450191lecithin
    Drug Bank Top

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    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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