AutismKB 2.0

Annotation Detail for EBP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:EBP ( CDPX2,CHO2,CPX,CPXD )
Gene Full Name: emopamil binding protein (sterol isomerase)
Band: Xp11.23
Quick LinksEntrez ID:10682; OMIM: 300205; Uniprot ID:EBP_HUMAN; ENSEMBL ID: ENSG00000147155; HGNC ID: 3133
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-341cholesterol biosynthesis I
PWY66-4cholesterol biosynthesis III (via desmosterol)
PWY66-3cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00100Steroid biosynthesis
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500825Cholesterol biosynthesis
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Chondrodysplasia punctata, X-linked dominant
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EBP mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EBP mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of EBP mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of EBP proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EBP mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of EBP mRNAdecreases expression 16704987
C053541 bicalutamide bicalutamide results in decreased expression of EBP mRNAdecreases expression 15638997
C006780 bisphenol A bisphenol A results in increased expression of EBP mRNAincreases expression 16474171
D002104 Cadmium Cadmium results in decreased expression of EBP mRNAdecreases expression 17547211
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of EBP mRNAdecreases expression 17547211
D016572 Cyclosporine Cyclosporine results in decreased expression of EBP mRNAdecreases expression 20106945
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene results in decreased expression of EBP mRNAdecreases expression 16498641
D004041 Dietary Fats Dietary Fats results in decreased expression of EBP mRNAdecreases expression 18042831
15238619
D004041 Dietary Fats Dietary Fats results in increased expression of EBP mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of EBP mRNAdecreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of EBP mRNAdecreases expression 17547211
D004958 Estradiol Estradiol results in decreased expression of EBP mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of EBP mRNAincreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of EBP mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EBP mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EBP mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil EBP protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
16217747
C056933 fumonisin B1 fumonisin B1 results in decreased expression of EBP mRNAdecreases expression 16221962
D019833 Genistein Genistein results in increased expression of EBP mRNAincreases expression 16474171
C041786 palm oil palm oil results in decreased expression of EBP mRNAdecreases expression 18042831
C041786 palm oil palm oil results in increased expression of EBP mRNAincreases expression 18042831
D010795 Phthalic Acids Phthalic Acids results in decreased expression of EBP mRNAdecreases expression 15728792
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of EBP mRNAincreases expression 16474171
D011374 Progesterone Progesterone results in increased expression of EBP mRNAincreases expression 18070364
D020849 Raloxifene Raloxifene binds to EBP proteinaffects binding 16033255
D013629 Tamoxifen Tamoxifen affects the expression of EBP mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EBP mRNAaffects cotreatment|increases expression 17942748
C034613 triacsin C triacsin C results in decreased expression of EBP mRNAdecreases expression 16704987
C025643 vinclozolin vinclozolin results in decreased expression of EBP mRNAdecreases expression 16498641
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 12.8116033868
MESH:D000230 Adenocarcinoma Estradiol 12.8111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.8114692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.8117638652
MESH:D000230 Adenocarcinoma Genistein 12.8111473722
MESH:D000236 Adenoma Diethylnitrosamine 6.4610737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 6.4619555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.1819052882 19061943 17162532 17620307 16434500 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1816835633
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 4.5416487989
MESH:D000419 Albuminuria Raloxifene 4.3417451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.4815800139
MESH:D000740 Anemia Fluorouracil 7.9317963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9311748828
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4319015723
MESH:D001161 Arteriosclerosis Dietary Fats 9.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5015885639
MESH:D050197 Atherosclerosis Cadmium 3.4915687053
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.1920106747
MESH:D001321 Autistic Disorder Acetaminophen 2.2318445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2318582451
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D001862 Bone Resorption bisphenol A 3.6311985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0717868700
MESH:D001930 Brain Injuries Progesterone 10.1115665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 10.1116580743
MESH:D001943 Breast Neoplasms bisphenol A 7.9917123778
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 7.9915061365
MESH:D001943 Breast Neoplasms Dietary Fats 7.9920435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.9917474063
MESH:D001943 Breast Neoplasms Estradiol 7.9917289903 16675129 12948864 17261762 18497071 19861407 17018787 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 7.9915136595 16557594 19217205 18357371 16595493 18608205 16110121
MESH:D001943 Breast Neoplasms Genistein 7.9916873071 17200150 16541309
MESH:D001943 Breast Neoplasms Progesterone 7.9915562024 17614352 16175315
MESH:D001943 Breast Neoplasms Raloxifene 7.9917261762 17595753 17952589 15775269 15758505 16837676 15572757 17242785 16912660 17049068 17893378 17440819
MESH:D001943 Breast Neoplasms Tamoxifen 7.9916273361 19289846 20065188 15565566 18997820 19155303 18821012 18815881 16818667 19115204 19288272 20544844 19244106 18629630 17440819 18425577 19066611 15668708 18984771 19142967 17049068 16202921 19487384 18351453 21138602 20135344 19059307 19011961 17242785 17893378 20005174 11161223 19410462 18855134 20390343 19189210 17261762 20859285 19103187 21152245 19200415 19189212 19084267 16873071 19221464
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.9920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4016051944
MESH:D002277 Carcinoma Dimethylnitrosamine 12.8119555203
MESH:D002277 Carcinoma Fluorouracil 12.8117121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.8116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2519066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.0116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 19.0116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.013084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 19.0121507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.0120101231 19539802 3581430 16328049 16807293 17978847 19418558 19171122 11831363 16502159 18665156 17055752 21159647 17761372 16681979 17138121 19822196 20514400 20007298 17173139 19519916 16288022 18785209 16878318 18056438 10672840 3084413 18788625 16698587 18393292 20935162 19701751 20524982 18506893 18494052 20727157 10737359 18978308 20512989 16935385 19107877 19208518 17428255 19919837 18971187 20214788 19052882 16540662 19394651 16569478 16779866 19335982 17162532 18210153 19383236 20084675 16830150 18691550 20432363
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.0116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 19.0118930000 17045692 17971768 17088986 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.0116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 19.0116924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7217123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8918695887
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.7116033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7116757204 18986760 17066447 16280240
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.7417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.7417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 6.9116332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.9115775269
MESH:D002386 Cataract Acetaminophen 2.4310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 19.206135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 19.2017332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.2012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.2021159647 7505956 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.2018566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5916835633
MESH:D002779 Cholestasis Cyclosporine 7.1419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1417110522 16919318 17681005 11677210 16105132 15861022 17333356
MESH:C538416 Chondrodysplasia punctata 2, X-linked dominant marker/mechanism 18176751
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9915340226 15668235 12621046 16354765 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.3615800139
MESH:D003110 Colonic Neoplasms Fluorouracil 3.6817018589 18772588 17169374 17287894 17016597 17172411 17725105 16340194 16510598 15001691
MESH:D003110 Colonic Neoplasms Genistein 3.6817182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8015148649 17094418 18802399 17255274 18509181 18288408 16331619 14970324 17401013 17594712 17454858 18383874 16303861 18949393 20501625 17016601 18448328 15289873 16524972 16282729 16391804 17695437
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.8015531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2420055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.0914966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.0318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.0318551238
MESH:D007644 Darier Disease Fluorouracil 4.5316733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.4716140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9417474826
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7020387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7016647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.7519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.7515920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.7519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2317187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.4310915739 17522070 11287661 16109766 10663392 11834606 12153990 19416960 19739265 11461765 19164858 16781746 12392966 15968718 16393943 12705907 12594235 18071297 11743745 12958197 19420014 19085960 11739529 16227642 16485898 16177239 18713872 14986274 12540782 11421492 19923254 17906064 2444490 14725611 11529661 16081117 17562736 10774834 15619225 19370779 14550746
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.4319107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 17.438172417
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 17.4316221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.4320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5711462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2718367378
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 5.0016487989
MESH:D004487 Edema Arachidonic Acid 10.2915177302 9599246 11698051 9831321 16716910 7990266
MESH:D004487 Edema Raloxifene 10.2915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.2911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6416714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.8612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.8617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 19.8615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.8619031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.3316402032
MESH:D016889 Endometrial Neoplasms Estradiol 11.4811473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 11.4811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.4816202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Progesterone 8.1716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.179294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8516302075
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.5817016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5816785472 17638652 16337965 16481741 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver Cyclosporine 27.6519224547
MESH:D005234 Fatty Liver Dietary Fats 27.6517967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 27.6520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.6515345470
MESH:D005234 Fatty Liver Raloxifene 27.6517473493
MESH:D005234 Fatty Liver Tamoxifen 27.6514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005334 Fever Arachidonic Acid 4.4311852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9219069698
MESH:D005355 Fibrosis Cyclosporine 13.2212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 13.2218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.2220067830
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005909 Glioblastoma Genistein 3.0916598420
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.2115102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1910048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.3611110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 4.7916487989
MESH:D006529 Hepatomegaly fumonisin B1 7.8716221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.8716120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7816959395 18606429 8697196 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.5016870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.3721332399
MESH:D006973 Hypertension Cyclosporine 7.9910903974
MESH:D006973 Hypertension Raloxifene 7.9917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 10.3817192596 12948891
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.3817937319
MESH:D007248 Infertility, Male vinclozolin 10.3816467254
MESH:D007249 Inflammation Arachidonic Acid 18.199831321 15177302 17371808
MESH:D007249 Inflammation Dietary Fats 18.1920412841
MESH:D007249 Inflammation Diethylnitrosamine 18.1918785209
MESH:D007249 Inflammation Progesterone 18.1915869954
MESH:D007249 Inflammation Tamoxifen 18.1919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.1912200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 11.3916393666
MESH:D007333 Insulin Resistance Dietary Fats 11.3918457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.3916393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007674 Kidney Diseases Acetaminophen 17.4715629191 12587719
MESH:D007674 Kidney Diseases Cadmium 17.4716226777 16962696 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 17.4716962696
MESH:D007674 Kidney Diseases Cyclosporine 17.4710903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 17.4715618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 26.3416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 26.3416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 26.3412371664
MESH:D007680 Kidney Neoplasms Estradiol 26.3415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 26.3416985049
MESH:D007680 Kidney Neoplasms Tamoxifen 26.3418625569
MESH:D007889 Leiomyoma Raloxifene 4.2516973256
MESH:D007938 Leukemia Genistein 2.8917468513 18980019
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4716417039
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 4.5112745335
MESH:D008064 Lipidoses Tamoxifen 2.9715342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 6.1518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.1518665156 19638242 18522880 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.3715733078 17666798 17432682 18095165 15763062 18672772 15086199 14709902 12925901 15369754 17640959 14726149 15339415 16009107 16270385 14643895 17881167 15067225 15081153 15383259 18237412 16042886 18364076 15864749 17719030 15942678 18371158 17201889 15366600 15492853 15099470 17724770 17465448 17036385 15479170 17348192 15842777 15577212 14659978 15161499 12918455 18210741 15723089 15798949 15298665 15571005 15591649 18637143 18239293 15793283 16570917 16627068 18567088 16603200 18629640 17203207 15744066 15138612 15504291 17198567 17534399 16544323 16169303 14568256 17196135
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.3717823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.3718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3712878042
MESH:D008107 Liver Diseases Acetaminophen 3.6719460945 16611625 19784758 16610002 19014921 12587719 12969438 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.6717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9216871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 8.9217457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.347678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.342125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.3420452335 2422723 12112319 19073162 19690152 19850985 12771043 20434301 19812893 10737359 19294768 20492335 19638242 19427195 19499222 19090486 20137499 16942905 21278145 15885732 19426721 20501860 15175105 19256749 19642983 18978307 21071580 21047994 21167192 20405173 20101389 18754104 2862719 19833225 18648771 19551842 19254457 9163691 18977376 18644402 20118626 19996281 20583210 19255062
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 20.343113478 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 20.3418383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms Tamoxifen 20.3416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.3416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 21.262876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 21.268603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.2618079962 19126423 19539802 21159647 16267830 18282651 19009564 18164116 18544905 18093689 19519916 17174075 9362446 17942915 18308698 3124819 16842330 18253720 17854601 19004024 18775883 2563599
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 21.2615603536 1848544 6150874
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 21.261423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.2612151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.1014755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.1020970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 8.1016061637 19555203 11884234
MESH:D008175 Lung Neoplasms Fluorouracil 8.1015246190
MESH:D008175 Lung Neoplasms Tamoxifen 8.1018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5315086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.9011408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.9014578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.9017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.9019196722 16827153 14580682 19196723 11731420
MESH:D020149 Manganese Poisoning Estradiol 11.7619453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7619453300
MESH:D008545 Melanoma Tamoxifen 1.8519393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2915863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4318986760 16757204
MESH:D009101 Multiple Myeloma Raloxifene 3.2616497877
MESH:D009203 Myocardial Infarction Genistein 2.7517141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.8517141266
MESH:D009232 Myxoma Raloxifene 5.2916343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.4718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.477678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.389029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4319410462
MESH:D009369 Neoplasms Fluorouracil 2.4916928823 18600527 18239605
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7319200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0619348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 21.3816427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 21.3811399458 16427766
MESH:D009421 Nervous System Malformations Genistein 21.3816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.3814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.4818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.4820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8520387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2616436463
MESH:D009765 Obesity Dietary Fats 2.2221332399 18457598 20518802 19632207 17217161 16723640 11836018 18674790 20132043
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.1316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.1316049721
MESH:D010024 Osteoporosis Genistein 6.8019401787
MESH:D010024 Osteoporosis Raloxifene 6.8017882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.3316169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.3315579764 17823083 17893378 15758505
MESH:D010049 Ovarian Diseases bisphenol A 4.7211985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.4219401270
MESH:D010051 Ovarian Neoplasms Genistein 7.4219005980
MESH:D010051 Ovarian Neoplasms Progesterone 7.4216525653 17393432
MESH:D010146 Pain Acetaminophen 2.1916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0016540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.0019003803 16929163 15113037 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3016702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1215687053
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.2112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.212563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.7210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.7211896295 11399792 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.7218042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.6718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.7720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.7720887781
MESH:D011471 Prostatic Neoplasms bicalutamide 2.8618487222 19011039 15638997 19240160 17914592
MESH:D011471 Prostatic Neoplasms bisphenol A 2.8616740699
MESH:D011471 Prostatic Neoplasms Cadmium 2.8617075824
MESH:D011471 Prostatic Neoplasms Estradiol 2.8616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.8619082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 2.8615378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.8615721890
MESH:D011471 Prostatic Neoplasms Raloxifene 2.8615731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.8615067354
MESH:D011472 Prostatitis vinclozolin 4.6718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.0516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5210548101
MESH:D011693 Purpura Raloxifene 5.2915770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7916160472 18286688 18722050 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012640 Seizures 2,4-dinitrotoluene 5.2818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.2818551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6716709447
MESH:D013088 Spermatocele Tamoxifen 10.6716709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.9915862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.9919457130
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.0012587719
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3318456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.3316033868
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3317172411 18396642 19084572 19015929 18567086 16951190 17498489 17522103 15786421 16424979
MESH:D020521 Stroke Raloxifene 3.6216837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.7216045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.797505956
MESH:D013978 Tibial Fractures Estradiol 12.8219048282
MESH:D013978 Tibial Fractures Raloxifene 12.8219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7616280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.0716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.0716049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.0717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.078653321 17572228 16712894
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.4716487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.1110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.1110091137
MESH:D014581 Urticaria Acetaminophen 2.7410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.6516803524
MESH:D014591 Uterine Diseases bisphenol A 4.7414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3014671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D015430 Weight Gain Dietary Fats 3.5216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00100 Steroid biosynthesis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved