AutismKB 2.0

Annotation Detail for PNMA2


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Basic Information Top
Gene Symbol:PNMA2 ( KIAA0883,MA2,MM2,RGAG2 )
Gene Full Name: paraneoplastic antigen MA2
Band: 8p21.2
Quick LinksEntrez ID:10687; OMIM: 603970; Uniprot ID:PNMA2_HUMAN; ENSEMBL ID: ENSG00000240694; HGNC ID: 9159
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D005472 Fluorouracil PNMA2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D008727 Methotrexate PNMA2 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PNMA2 mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 11.2012039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.2015322242 11752688 14514962
MESH:D000230 Adenocarcinoma Fluorouracil 2.5017638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.1216835633
MESH:D000740 Anemia Fluorouracil 10.2017963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 10.2011748828
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1717286800
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D001943 Breast Neoplasms Fluorouracil 1.9815136595 18357371 19217205 18608205 16595493 16110121 16557594
MESH:D001943 Breast Neoplasms Methotrexate 1.9816978400
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.5316051944
MESH:D002277 Carcinoma Fluorouracil 9.4217121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.4216835633
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1216799960 17088986 17045692 18930000 16332177 17971768
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1818695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5816280240 16757204 18986760 17066447
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5818850075 16120746 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2515668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2917725105 15001691 17172411 16510598 17169374 16340194 18772588 17018589 17016597 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017255274 16524972 18949393 17401013 17594712 17695437 17016601 16303861 18288408 18802399 16391804 16282729 18448328 18509181 15289873 14970324 17094418 18383874 16331619 20501625 15148649 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4814669216 17141729
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.859562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8515322242 10048152 20055451
MESH:D003550 Cystic Fibrosis Methotrexate 4.6819747007
MESH:D007644 Darier Disease Fluorouracil 5.5316733453
MESH:D003882 Dermatomyositis Methotrexate 5.7120191521
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7716714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4710568697 9294722
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5316481741 16337965 15173087 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.6020067830
MESH:D005910 Glioma Fluorouracil 3.0016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.8016518429
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6718337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.5415340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.9115340226 16354765 8697196 18606429 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0318850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0412200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D007680 Kidney Neoplasms Fluorouracil 3.6916985049
MESH:D007805 Language Development Disorders Methotrexate 5.639562676
MESH:D008103 Liver Cirrhosis Methotrexate 3.9114986274
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Fluorouracil 4.9415113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.9416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3512151625
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.8918516814
MESH:D008175 Lung Neoplasms Fluorouracil 2.4415246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4411884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.5315086387
MESH:D008223 Lymphoma Methotrexate 4.2617352296
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9816757204 18986760
MESH:D052016 Mucositis Methotrexate 6.0217488658
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3812213967
MESH:D009369 Neoplasms Fluorouracil 2.7918600527 16928823 18239605
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8014600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.7216436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7819003803 16500647 15113037 16929163
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.9311399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3419082440 18626508
MESH:D011565 Psoriasis Methotrexate 3.5517410198
MESH:D012004 Rectal Neoplasms Fluorouracil 4.4316160472 18286688 18722050 15538739
MESH:D051437 Renal Insufficiency Methotrexate 5.3617352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2116192470
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018396642 17498489 17522103 15786421 16424979 16951190 19084572 18567086 17172411 19015929
MESH:D013576 Syndactyly Methotrexate 5.629562676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.4416280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.3316803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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