AutismKB 2.0

Annotation Detail for CCT8


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Basic Information Top
Gene Symbol:CCT8 ( C21orf112,Cctq,D21S246,KIAA0002,PRED71 )
Gene Full Name: chaperonin containing TCP1, subunit 8 (theta)
Band: 21q21.3
Quick LinksEntrez ID:10694; OMIM: NA; Uniprot ID:TCPQ_HUMAN; ENSEMBL ID: ENSG00000156261; HGNC ID: 1623
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of proteins
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Pathway IDPathway Name
500534Formation of tubulin folding intermediates by CCT/TriC
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CCT8 mRNAaffects expression 21346803
C024709 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to CCT8 proteinaffects binding 16533022
D001104 Arbutin Arbutin results in increased expression of CCT8 mRNAincreases expression 17103032
C006632 arsenic trioxide arsenic trioxide results in increased expression of CCT8 mRNAincreases expression 20458559
C110172 BHTOH-QM BHTOH-QM binds to CCT8 proteinaffects binding 16533022
D004958 Estradiol Estradiol affects the expression of CCT8 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CCT8 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCT8 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CCT8 mRNAdecreases expression 15056799
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCT8 mRNAaffects cotreatment|increases expression 17942748
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of CCT8 mRNAdecreases expression 15289447
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma arsenic trioxide 7.3119825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 7.3111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3114692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.8515814487
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2219898480
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Estradiol 1.9219861407 18497071 17261762 14630087 17289903 12948864 16675129 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7415553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7416924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4811212258
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 3.2611212258
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9118566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0217110522 16105132 15861022 16919318 17333356 17681005 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 15340226 16354765 15668235 8697196
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.8721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.1118566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3512903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 8.4315073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.4315345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 16959395 16354765 18606429 15340226
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5712878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 5.5718590791
MESH:D007333 Insulin Resistance Estradiol 3.0916627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Estradiol 2.6915618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms Estradiol 7.9415610895
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1620471514 17050201 16968895 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3415336539 17649720 15748426 12018890 16331271 17217047 19225113 11468182 15622746 17712046 16966277 15213294 16330433 9834237 11161223 16823087 17869043 16112521 19075265 12712474 12679006 16891316 19642359 17107899 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008113 Liver Neoplasms arsenic trioxide 4.6614682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.2120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6219825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6211884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 3.6211091918 3440675 16288123 12111688
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6817203775 11807958 11408345 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.5015006635
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2519417148 14977855 19549372 15949261 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 10.2716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6216049721 12819281
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0119769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 5.0119401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11399792 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1719131511
MESH:D011471 Prostatic Neoplasms Estradiol 3.1716740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.8818410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.1916192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 6.1918590791
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8616049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.8620435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 8.8612846360
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:17015 Metabolism of proteins
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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