AutismKB 2.0

Annotation Detail for ADCY1


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Basic Information Top
Gene Symbol:ADCY1 ( AC1 )
Gene Full Name: adenylate cyclase 1 (brain)
Band: 7p12.3
Quick LinksEntrez ID:107; OMIM: 103072; Uniprot ID:ADCY1_HUMAN; ENSEMBL ID: ENSG00000164742; HGNC ID: 232
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04720Long-term potentiation
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
hsa05142Chagas disease
hsa05146Amoebiasis
hsa04540Gap junction
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa00230Purine metabolism
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Integration of energy metabolism
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
P05731GABA-B receptor II signaling
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ADCY1 mRNAdecreases expression 19933214
D002220 Carbamazepine Carbamazepine inhibits the reaction [Forskolin results in increased activity of ADCY1 protein]decreases reaction|increases activity 19922557
D002220 Carbamazepine Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY1 protein]affects binding|decreases reaction|increases activity 19922557
D002220 Carbamazepine Carbamazepine results in decreased activity of ADCY1 proteindecreases activity 19922557
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of ADCY1 mRNAdecreases expression 17452286
C017180 decamethrin decamethrin results in decreased activity of ADCY1 proteindecreases activity 2957417
D003976 Diazinon Diazinon results in decreased expression of ADCY1 mRNAdecreases expression 17452286
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ADCY1 mRNAincreases expression 15766595
D005576 Forskolin Carbamazepine inhibits the reaction [Forskolin results in increased activity of ADCY1 protein]decreases reaction|increases activity 19922557
D005576 Forskolin Forskolin results in increased activity of ADCY1 proteinincreases activity 19922557
D026023 Permethrin Permethrin results in decreased activity of ADCY1 proteindecreases activity 2957417
C071262 SK&F 82958 Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY1 protein]affects binding|decreases reaction|increases activity 19922557
C071262 SK&F 82958 [SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY1 proteinaffects binding|increases activity 19922557
C017947 sodium arsenite sodium arsenite results in increased expression of ADCY1 mRNAincreases expression 17879257
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADCY1 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 9.358986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.3514514962 15322242 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1216712894 17306315
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.8317119214 11874814 16611668
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.8316487989
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001714 Bipolar Disorder Carbamazepine 4.2020046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.1015324884 17129689
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.2815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.2815276417 17306315 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0820056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.158697196 15668235 16354765 15340226 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Carbamazepine 5.699014606
MESH:D019465 Craniofacial Abnormalities decamethrin 5.6919861644
MESH:D019465 Craniofacial Abnormalities Permethrin 5.6919861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.6915322242 10048152 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7216002989 12952375
MESH:D003877 Dermatitis, Contact Permethrin 5.1414617103
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.6211748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.4916538175 20216337 15057820 16538176
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 4.2817465707
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.2820420201
MESH:D004362 Drug Toxicity Carbamazepine 8.7520216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.7511462148
MESH:D004417 Dyspnea Diazinon 5.0216487989
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.8917654737
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5516804899 15700306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.4216538176 19915237 16415921 20485159 18855540
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.3917275665
MESH:D004828 Epilepsies, Partial Carbamazepine 5.1915008574 16628512 17116037
MESH:D004827 Epilepsy Carbamazepine 4.0620417680 7988514 19620853 821787 19439326 17465707 19700373 17178248 9014606 18234410
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.537750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.3115276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 5.9219549232
MESH:D005076 Exanthema Carbamazepine 5.6620485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7316534752 15751030 16611131 16002989 16513791
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 13.4716452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 13.4716452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Diazinon 4.7316487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 8697196 18606429 16354765 15340226
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.8510459572
MESH:D006965 Hyperplasia Carbamazepine 11.9018773962
MESH:D006965 Hyperplasia Diethylstilbestrol 11.9014722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 4.7516002989
MESH:D007246 Infertility Diethylstilbestrol 4.5215036965
MESH:D007248 Infertility, Male Diazinon 7.4412948887 16466525
MESH:D007248 Infertility, Male sodium arsenite 7.4415346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007299 Insect Bites and Stings decamethrin 13.8815189238
MESH:D007299 Insect Bites and Stings Permethrin 13.8815189238 12971516 12749493
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases sodium arsenite 2.8720008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.5815003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2417184923
MESH:D007938 Leukemia Permethrin 4.1912937054
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Chlorpyrifos 3.1015991261
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.7515890375 16712894
MESH:D008113 Liver Neoplasms sodium arsenite 7.7516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3417306315 17077188 15276417 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3419555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.6016628512
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7316002989
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008607 Mental Retardation Carbamazepine 3.769014606
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009224 Myotonia Congenita Carbamazepine 5.6620399394
MESH:D009369 Neoplasms Diethylstilbestrol 5.4515313581
MESH:D009369 Neoplasms sodium arsenite 5.4511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009421 Nervous System Malformations Carbamazepine 17.5216990009
MESH:D009421 Nervous System Malformations Diethylstilbestrol 17.5211399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.5214600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2312854658
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2615081274
MESH:D010018 Osteomalacia Carbamazepine 5.6617016548
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4715276417 17306315
MESH:D010146 Pain Carbamazepine 4.1515215642
MESH:D010267 Parapsoriasis Carbamazepine 5.8816538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 6.1217679678 17145499
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8515687265 16977796
MESH:D011041 Poisoning Diazinon 4.5017603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011248 Pregnancy Complications Carbamazepine 5.339014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 17.599014606
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 17.5917184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.5911896295 11399792 11222880 11118676
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3715846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3716039940
MESH:D019310 Pseudolymphoma Carbamazepine 5.8212752131 9591791
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.8116611668 17119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.1116611668 17119214
MESH:D012640 Seizures Carbamazepine 3.8816180713 9844417 15946322 9046859 16876388 16938433 19414003
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.316418539
MESH:D012878 Skin Neoplasms sodium arsenite 5.7918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7916192470
MESH:D012893 Sleep Disorders Carbamazepine 5.3119414003
MESH:D013088 Spermatocele Diethylstilbestrol 4.9316002989 16709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.3916415921 15057820 19915237 16538176 19694795 18855540 20485159
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.4416712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.4416452187 11723127 16712894 17306315
MESH:D014570 Urologic Diseases Diazinon 5.4916487989
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.9816175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.9811813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.2315809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6116002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04976 Bile secretion
KEGG:04020 Calcium signaling pathway
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:04062 Chemokine signaling pathway
KEGG:05414 Dilated cardiomyopathy
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:04720 Long-term potentiation
KEGG:04916 Melanogenesis
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:00230 Purine metabolism
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24560
    • No data
    No data
    Releated drug ID Related drug Name
    PA449396dopamine
    PA164744376adenosine monophosphate
    PA449773glucose
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA164743471adenosine triphosphate
    PA451123progesterone
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    PA164749238exenatide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00131 binder Adenosine monophosphate Dietary supplement;Micronutrient
    DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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