AutismKB 2.0

Annotation Detail for CETP


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Basic Information Top
Gene Symbol:CETP ( HDLCQ10 )
Gene Full Name: cholesteryl ester transfer protein, plasma
Band: 16q13
Quick LinksEntrez ID:1071; OMIM: 118470; Uniprot ID:CETP_HUMAN; ENSEMBL ID: ENSG00000087237; HGNC ID: 1869
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500798LDL-mediated lipid transport
500795Lipoprotein metabolism
500797HDL-mediated lipid transport
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1904Diabetes mellitus
1934Cancer
1951Overnutrition
2203Nephrosis
2236Cardiovascular disease
Desease Name
hypercholesterolemia
HDL cholesterol
Biochemical measures
cholesterol
macroangiopathy
cholesterol cholesterol, HDL cholesterol, LDL lipoprotein triglycerides
cognitive function
cardiovascular disease
cholesterol, HDL
Atrial Fibrillation
cholesteryl ester transfer protein plasma lipid levels
AGING
atherosclerosis, coronary
CARDIOVASCULAR
Coronary Artery Disease
myocardial infarct
Diabetes Mellitus
atherosclerosis, carotid
plasma HDL cholesterol (HDL-C) levels
plasma high-density lipoprotein cholesterol levels
cardiovascular events in non-smokers
PSYCH
Lipid disorders
cholesterol, HDL obesity
cholesteryl ester transfer protein
lipoprotein
low CETP activity
Cholesterol, HDL/blood*
low high-density lipoprotein cholesterol concentration
METABOLIC
LDL cholesterol
triglycerides
obesity
plasma HDL-C levels
waist circumference and related phenotypes
REPRODUCTION
diabetes, type 2
cholesterol, HDL cholesterol, LDL
carotid atherosclerosis
high plasma CETP activity.
exceptional longevity
patent ductus arteriosus
Desease Name
HDL cholesterol
Biochemical measures
Cholesterol
Metabolic syndrome
Waist circumference and related phenotypes
Blood lipid traits
Cardiovascular disease risk factors
Triglycerides
LDL cholesterol
Age-related macular degeneration
Desease Name
CETP deficiency
Hyperalphalipoproteinemia
High density lipoprotein cholesterol level QTL 10
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C003585 22-hydroxycholesterol 22-hydroxycholesterol results in increased expression of CETP mRNAincreases expression 16142410
C003585 22-hydroxycholesterol [alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of CETP mRNAaffects cotreatment|increases expression 16142410
C103303 alitretinoin [alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of CETP mRNAaffects cotreatment|increases expression 16142410
C103303 alitretinoin [alitretinoin co-treated with TO-901317] results in increased expression of CETP mRNAaffects cotreatment|increases expression 16142410
C103303 alitretinoin alitretinoin results in increased expression of CETP mRNAincreases expression 16142410
D008076 Cholesterol, HDL CETP gene polymorphism affects the abundance of Cholesterol, HDLaffects abundance 16030523
D005632 Fructose Fructose results in increased expression of and results in increased activity of CETP proteinincreases activity|increases expression 11476189
D005632 Fructose Fructose results in increased expression of CETP mRNAincreases expression 11476189
C473027 GW 3965 GW 3965 results in increased expression of CETP mRNAincreases expression 19426978
D019829 Nevirapine Nevirapine results in increased expression of CETP proteinincreases expression 19667106
C025299 polyphenols polyphenols results in decreased activity of CETP proteindecreases activity 16046716
C423915 TO-901317 [alitretinoin co-treated with TO-901317] results in increased expression of CETP mRNAaffects cotreatment|increases expression 16142410
C423915 TO-901317 TO-901317 results in increased expression of CETP mRNAincreases expression 16142410
19426978
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D001943 Breast Neoplasms alitretinoin 3.0916344269
OMIM:607322 CHOLESTERYL ESTER TRANSFER PROTEIN DEFICIENCY marker/mechanism
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D003327 Coronary Disease Fructose 4.6218504504
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.6918603373
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 3.4218603373
MESH:D056486 Drug-Induced Liver Injury Nevirapine 5.1514986274
MESH:D056486 Drug-Induced Liver Injury polyphenols 5.1519370779
MESH:D050171 Dyslipidemias marker/mechanism 17952847
MESH:D005234 Fatty Liver Fructose 4.6119196556 18395287 18641190
MESH:D005355 Fibrosis Fructose 4.9618504504
MESH:D018149 Glucose Intolerance Fructose 5.5819165636
MESH:D015658 HIV Infections Nevirapine 5.0011141242
OMIM:143470 HYPERALPHALIPOPROTEINEMIA marker/mechanism
MESH:D006946 Hyperinsulinism Fructose 5.1014757778 15752949 18360027 18563319 19008412
MESH:D006949 Hyperlipidemias Fructose 5.0115752949
MESH:D006938 Hyperlipoproteinemia Type II marker/mechanism 16030523
MESH:D006973 Hypertension Fructose 3.6914573337 16843071 19008412 14633139 14568997
MESH:D015228 Hypertriglyceridemia Fructose 5.3119342510 19799862
MESH:D007249 Inflammation polyphenols 3.1716366677
MESH:D007333 Insulin Resistance Fructose 4.3918981581 14573337 18057795 14757778 19586609 19342510 19799862 19008412 18563319 14633139 17133782
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.9816144296
MESH:D008052 Lipid Metabolism, Inborn Errors marker/mechanism
MESH:D008107 Liver Diseases polyphenols 2.8316698588
MESH:D008175 Lung Neoplasms alitretinoin 2.6516413115
MESH:D024821 Metabolic Syndrome X Fructose 5.0219165636 17098227 17261469 18497449 16815490
MESH:D009369 Neoplasms alitretinoin 3.3516946489
MESH:D009376 Neoplasms, Hormone-Dependent Nevirapine 6.5119152342
MESH:D009765 Obesity Fructose 3.4718585860 17707055
MESH:D017499 Porokeratosis alitretinoin 6.3816144296
MESH:D011471 Prostatic Neoplasms Nevirapine 5.2419152342
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.6317997062
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA108
    • Releated gene ID Related gene Name
    PA108CETP
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    PA443853Dementia
    PA443635Cardiovascular Diseases
    PA447159Metabolic Syndrome X
    PA443425Arteriosclerosis
    PA443362Angina Pectoris
    PA443364Angina, Unstable
    PA447054Stroke
    PA443797Coronary Disease
    PA443842Death
    PA444552Hypertension
    PA445019Myocardial Infarction
    PA443796Coronary Artery Disease
    PA446414Carotid Stenosis
    Releated drug ID Related drug Name
    PA133950441hmg coa reductase inhibitors
    PA450952phospholipids
    PA145007158torcetrapib
    PA449688fluvastatin
    PA165107062CP-800,569
    PA145007158torcetrapib
    PA448500atorvastatin
    PA451089pravastatin
    PA450480metoprolol
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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