AutismKB 2.0

Annotation Detail for TBR1


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Basic Information Top
Gene Symbol:TBR1 ( MGC141978,TES-56 )
Gene Full Name: T-box, brain, 1
Band: 2q24.2
Quick LinksEntrez ID:10716; OMIM: 604616; Uniprot ID:TBR1_HUMAN; ENSEMBL ID: ENSG00000136535; HGNC ID: 11590
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019833 Genistein Genistein results in decreased expression of TBR1 mRNAdecreases expression 16169203
D009151 Mustard Gas Mustard Gas results in increased expression of TBR1 mRNAincreases expression 15674844
D014212 Tretinoin Tretinoin results in decreased expression of TBR1 mRNAdecreases expression 17045167
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Genistein 2.5611473722
MESH:D000505 Alopecia Tretinoin 3.9815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.3216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3416292516
MESH:D001249 Asthma Mustard Gas 5.3310378619
MESH:D001249 Asthma Tretinoin 5.3316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.9916935849
MESH:D001768 Blister Mustard Gas 5.9019167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0916197459 16206674
MESH:D001943 Breast Neoplasms Genistein 2.2516873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tretinoin 2.2516443354 16873071 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.9015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.8417687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.3316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 6.0316168501
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.3016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.301917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3816096774 16051514
MESH:D002318 Cardiovascular Diseases Genistein 3.5916332659
MESH:D002386 Cataract Tretinoin 3.3217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.3316129372
MESH:D002822 Choriocarcinoma Tretinoin 6.0316461808
MESH:D002972 Cleft Palate Tretinoin 2.819407595
MESH:D003092 Colitis Tretinoin 4.3517035595
MESH:D003110 Colonic Neoplasms Genistein 2.3417182828
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9142499 17551590 9211117 14991402 16925845 8800419 9224671 9664655 9125849
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5616647724
MESH:D004487 Edema Mustard Gas 3.7811428647 9260866 11428631 11402378
MESH:D004489 Edema, Cardiac Tretinoin 5.3318230668
MESH:D004714 Endometrial Hyperplasia Genistein 5.3316402032
MESH:D016889 Endometrial Neoplasms Genistein 8.4611473722
MESH:D016889 Endometrial Neoplasms Tretinoin 8.4616569247
MESH:D004890 Erythema Mustard Gas 5.909357497
MESH:D005124 Eye Abnormalities Tretinoin 3.909664655 16938888
MESH:D005355 Fibrosis Tretinoin 4.1617994277
MESH:D005909 Glioblastoma Genistein 8.1116598420
MESH:D005909 Glioblastoma Tretinoin 8.1117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 6.0316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0914991402 9664655
MESH:D006930 Hyperalgesia Tretinoin 3.5716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.2216778211
MESH:D007249 Inflammation Mustard Gas 2.9817524151 16001271 9357497 11402378 11428647 11428620 8975870 11428631 9260866
MESH:D007410 Intestinal Diseases Tretinoin 4.4217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3915992940 17551590
MESH:D007938 Leukemia Genistein 7.0317468513 18980019
MESH:D007938 Leukemia Tretinoin 7.0317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1317596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.4216935935 19029980 17301526 17506722 16823087 17339181 17361223 17712046 17294898 17217047 17649720 19035177 16788101 17107899 16891316 12679006 19075265 16766008 17368321 16331271 19225113 15748426 9834237 16140955 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.629224671
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.7117823541
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.7116248980 18397230
MESH:D008171 Lung Diseases Mustard Gas 3.7318702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 2.188781369 3148597
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.2014578162 12929590
MESH:D008527 Medulloblastoma Tretinoin 2.9217453147
MESH:D008545 Melanoma Tretinoin 1.9916752155
MESH:D008591 Meningomyelocele Tretinoin 5.0816940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.3017596541
MESH:D009203 Myocardial Infarction Genistein 3.0017141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 4.0017141266
MESH:D009369 Neoplasms Tretinoin 2.5916594593 16946489
MESH:D009421 Nervous System Malformations Genistein 11.8316427766
MESH:D009421 Nervous System Malformations Tretinoin 11.839125849
MESH:D009436 Neural Tube Defects Tretinoin 3.329142499
MESH:D009503 Neutropenia Mustard Gas 4.507688884 16761898
MESH:D010024 Osteoporosis Genistein 3.5019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.6116169203
MESH:D010051 Ovarian Neoplasms Genistein 5.3019005980
MESH:D010051 Ovarian Neoplasms Tretinoin 5.3016936753
MESH:D010146 Pain Tretinoin 3.2816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5815976015
MESH:D011041 Poisoning Mustard Gas 4.3215727166
MESH:D011471 Prostatic Neoplasms Genistein 3.4015256057 16925846 15378649
MESH:D011507 Proteinuria Tretinoin 4.1316636307
MESH:D011537 Pruritus Mustard Gas 4.8318058305
MESH:D011625 Pterygium Tretinoin 5.5416723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0617720292 10334151 17266442 17894541 17620002
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.6316116481 16283617
MESH:D012871 Skin Diseases Mustard Gas 2.8012880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tretinoin 2.7816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.2416051514
MESH:D014376 Tuberculosis Tretinoin 3.4716040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.1216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.4816752155
MESH:D014820 Vitiligo Tretinoin 4.6416761959
MESH:D009396 Wilms Tumor Tretinoin 4.3916287080
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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