AutismKB 2.0

Annotation Detail for NFAT5


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Basic Information Top
Gene Symbol:NFAT5 ( KIAA0827,NF-AT5,NFATL1,NFATZ,OREBP,TONEBP )
Gene Full Name: nuclear factor of activated T-cells 5, tonicity-responsive
Band: 16q22.1
Quick LinksEntrez ID:10725; OMIM: 604708; Uniprot ID:NFAT5_HUMAN; ENSEMBL ID: ENSG00000102908; HGNC ID: 7774
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa04310Wnt signaling pathway
hsa04370VEGF signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
No data
No data
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026114 2-xylene 2-xylene results in increased expression of NFAT5 mRNAincreases expression 20359517
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NFAT5 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of NFAT5 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of NFAT5 mRNAincreases expression 18687144
D001554 Benzene Benzene results in increased expression of NFAT5 mRNAincreases expression 20359517
C090535 benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Doxorubicin results in increased degradation of NFAT5 protein]decreases reaction|increases degradation 17105721
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of NFAT5 protein]decreases reaction|increases degradation 17105721
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of NFAT5 mRNAincreases expression 16934159
D004317 Doxorubicin benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Doxorubicin results in increased degradation of NFAT5 protein]decreases reaction|increases degradation 17105721
D004317 Doxorubicin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of NFAT5 protein]decreases reaction|increases degradation 17105721
D004317 Doxorubicin Doxorubicin affects the localization of NFAT5 proteinaffects localization 17105721
D004317 Doxorubicin Doxorubicin results in decreased activity of NFAT5 proteindecreases activity 17105721
D004317 Doxorubicin Doxorubicin results in increased degradation of and results in decreased expression of NFAT5 proteindecreases expression|increases degradation 17105721
C004912 ethylbenzene ethylbenzene results in increased expression of NFAT5 mRNAincreases expression 20359517
D008752 Methylene Chloride Methylene Chloride results in increased expression of NFAT5 mRNAincreases expression 20359517
C030517 myxothiazol myxothiazol inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]decreases reaction|increases activity 16303854
C006253 pirinixic acid pirinixic acid results in decreased expression of NFAT5 mRNAdecreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of NFAT5 mRNA]decreases expression|increases reaction 17950772
D017382 Reactive Oxygen Species [Sodium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFAT5 proteinincreases abundance|increases activity 16303854
D012402 Rotenone Rotenone inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]decreases reaction|increases activity 16303854
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of NFAT5 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of NFAT5 mRNAdecreases expression 19244175
D012965 Sodium Chloride myxothiazol inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]decreases reaction|increases activity 16303854
D012965 Sodium Chloride Rotenone inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]decreases reaction|increases activity 16303854
D012965 Sodium Chloride [Sodium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFAT5 proteinincreases abundance|increases activity 16303854
D012965 Sodium Chloride Sodium Chloride results in increased activity of NFAT5 proteinincreases activity 16303854
C004648 testosterone enanthate testosterone enanthate results in increased expression of NFAT5 mRNAincreases expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of NFAT5 mRNAaffects expression 18691609
D014050 Toluene Toluene results in increased expression of NFAT5 mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of NFAT5 mRNAincreases expression 20359517
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of NFAT5 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of NFAT5 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7211752688 14514962 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Doxorubicin 2.5417418594
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.683712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.4616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.4616835633
MESH:D000419 Albuminuria Doxorubicin 4.4221441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000741 Anemia, Aplastic Benzene 4.2711369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.891440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3712125929
MESH:D001836 Body Weight Changes 2-xylene 11.677457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.6715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001855 Bone Marrow Diseases Benzene 5.1016183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5714601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.6917150277
MESH:D001943 Breast Neoplasms Benzene 2.3511921183 17162533
MESH:D001943 Breast Neoplasms Doxorubicin 2.3516096432 15136595 18695136 16935488 15668708 16595493 16264153 15634643 15939500 16826403 19526202 17983394 18234424 15994142 18628466 11325840 15993339 15567936 16115903 18382427 17426702 17369602 15692762 16322301
MESH:D001943 Breast Neoplasms Methylene Chloride 2.3515986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D001943 Breast Neoplasms Trichloroethylene 2.3515986119
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8016050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.457296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.453084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.4516234567 18059187 17876044 16023760
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.357296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.3516201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.606189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3018670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4417519947 17924179 17131338 16278810 15476868 15792986 16109756 17974986 15505089 16952015 17308081 17007740 16612575 16455267 16651473 15811867 16731534 17382496 17329180 16242529 16364871 17351982 16269455 18627295 17928571
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9017334414 16243910
MESH:D002386 Cataract Acetaminophen 2.5110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.677505956
MESH:D002547 Cerebral Palsy Toluene 5.729294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.5219486331 9022650
MESH:D002779 Cholestasis pirinixic acid 7.5219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0516354765 15340226 12621046 8697196 15668235
MESH:D003092 Colitis Selenium 3.6517936198
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9517141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 7.2215643154
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 7.2215736158
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.2210048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 7.229294310
MESH:D019465 Craniofacial Abnormalities Vitamin E 7.2219769572
MESH:D003643 Death Toluene 5.546431079
MESH:D003872 Dermatitis Benzene 4.6415902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6812868966 18759878 8156756 2524372 14531868 11906362 11298694 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.373621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.109653073 18692083 7440962 1440618 9022650 18289764 6482804 18648102 9328219 8291058 11289319 6679447 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.1019370779 15968718 11739529 19085960 18071297 15619225 10774834 19923254 12594235 10915739 16485898 16081117 19164858 11461765 10663392 19416960 16393943 16109766 12153990 16227642 17906064 11421492 12540782 12958197 12392966 14725611 19420014 11834606 12705907 16781746 17562736 17522070 14550746 14986274 11529661 2444490 11743745 19739265 18713872 16177239 11287661
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 18.1017851650
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 18.1017416283
MESH:D056486 Drug-Induced Liver Injury Selenium 18.1015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.1020420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 18.107120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D004362 Drug Toxicity Doxorubicin 7.7918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7911462148
MESH:C538011 Eales disease Vitamin E 4.579068938
MESH:D004487 Edema pirinixic acid 6.1412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7715322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.3717359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0318037988
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.083581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver pirinixic acid 2.6520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.896705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4619069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8220067830
MESH:D005756 Gastritis Acetaminophen 3.5516983495
MESH:D005909 Glioblastoma Doxorubicin 3.2617150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.917505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4415692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3411294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.3416080930
MESH:D006331 Heart Diseases Doxorubicin 3.3916707910 16144979 18674790 16495754 14766674 12587719 18006777 16244371 17875725 16330681 16879835 17888722 16244372
MESH:D006333 Heart Failure Doxorubicin 11.3417481944
MESH:D006333 Heart Failure pirinixic acid 11.3420558911
MESH:D006333 Heart Failure Selenium 11.3417162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7815692506
MESH:D006402 Hematologic Diseases Benzene 4.5316183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.396705139
MESH:D006529 Hepatomegaly 2-xylene 13.837457013 7457028
MESH:D006529 Hepatomegaly pirinixic acid 13.8319772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.8315340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616490937 16863852
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6217440010
MESH:D006689 Hodgkin Disease Doxorubicin 3.3017606976 18501091 15147373
MESH:D019584 Hot Flashes Vitamin E 3.8414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9216354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.6016870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8115034207
MESH:D006973 Hypertension Benzene 8.5917940673
MESH:D006973 Hypertension Sodium Chloride 8.5911507004
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5918850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7912878042 12200463
MESH:D007251 Influenza, Human Selenium 10.5316624496
MESH:D007251 Influenza, Human Vitamin E 10.5316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5516306350
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.8319381132
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.899022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007674 Kidney Diseases Acetaminophen 9.6715629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 9.6715699352 15369732 16775033
MESH:D007674 Kidney Diseases Vitamin E 9.6712488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.5816707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.5816518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.866582329
MESH:D016773 Leishmaniasis, Cutaneous Sodium Chloride 4.829499605
MESH:D007938 Leukemia Benzene 3.3317119257 14694614 15935818 18335105
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0316085563
MESH:D007951 Leukemia, Myeloid Benzene 4.2017506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6819478238
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.119327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.8116439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.8116169303
MESH:D008107 Liver Diseases Acetaminophen 1.6019014921 11587558 16611625 19784758 12969438 16610002 19460945 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1217185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.0816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.0816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.81598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Benzene 17.8112562636
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.8116842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.8112151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 17.817955063
MESH:D008171 Lung Diseases Vitamin E 3.0916863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6814698565
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8917365036
MESH:D008175 Lung Neoplasms Benzene 6.4612562636
MESH:D008175 Lung Neoplasms Doxorubicin 6.466189445 17418594
MESH:D008175 Lung Neoplasms Methylene Chloride 6.4615172992
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4611884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.4611062179
MESH:D008223 Lymphoma Benzene 7.5317119257 17584886
MESH:D008223 Lymphoma Doxorubicin 7.5316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4415621674
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.3112562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.6311921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.6315458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.6315318939
MESH:D008545 Melanoma Doxorubicin 3.8116827129
MESH:D008545 Melanoma Reactive Oxygen Species 3.8117992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4419513568
MESH:D008607 Mental Retardation Toluene 3.619294310
MESH:D008654 Mesothelioma Asbestos, Crocidolite 9.9616966607 18303189 16166281
MESH:D008654 Mesothelioma Doxorubicin 9.9617638057
MESH:D008654 Mesothelioma Selenium 9.9615107826
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3815792986
MESH:D019957 Motor Skills Disorders Toluene 5.119294310
MESH:D052016 Mucositis Doxorubicin 4.6617415656
MESH:D009101 Multiple Myeloma Benzene 3.5717119195
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009203 Myocardial Infarction Doxorubicin 5.5315857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.5319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8416411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.673581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.6718259882
MESH:D009369 Neoplasms pirinixic acid 5.1217405874
MESH:D009369 Neoplasms Trichloroethylene 5.1211911487
MESH:D009401 Nephrosis Doxorubicin 4.6416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8916889571 15640375
MESH:D009410 Nerve Degeneration Rotenone 3.7817356569 18619942 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.176679447
MESH:D009436 Neural Tube Defects Benzene 7.1715643154
MESH:D009447 Neuroblastoma Doxorubicin 3.2015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7618514411
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.776482804 4026338
MESH:D009784 Occupational Diseases Benzene 8.7717119257 16737584 15612468 15913788 15727169 17178637 15935809 15576619 17479406
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.893988306
MESH:D012516 Osteosarcoma Doxorubicin 4.0115930896
MESH:D010051 Ovarian Neoplasms Benzene 2.9312562636
MESH:D010146 Pain Acetaminophen 2.2916870215
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 3.6515580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.357296757
MESH:D010300 Parkinson Disease Rotenone 2.9311535288 16140633 11445065 16412576 19114014 18191903 15451049 18619942 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 3.9615927086 15574749 15795934 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.346228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0317983394
MESH:D010954 Plasmacytoma Selenium 4.7615087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7610923243
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4515897917 15749863 16729912 16888761 16868541 18437689
MESH:D011471 Prostatic Neoplasms Vitamin E 3.4515084515
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9817322281 17975199 15814490 17365031
MESH:D051437 Renal Insufficiency Doxorubicin 4.0917922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.283692021
MESH:D012509 Sarcoma Doxorubicin 3.8717203757 15625365 17710206 16767912 18313854 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1116326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6617846226
MESH:D012640 Seizures Toluene 3.636431079 9294310
MESH:D012871 Skin Diseases Vitamin E 2.4118709164
MESH:D012878 Skin Neoplasms Doxorubicin 5.4815692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4816192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4415625365 17203757 16767912
MESH:D013274 Stomach Neoplasms Benzene 3.2112562636
MESH:D013274 Stomach Neoplasms Sodium Chloride 3.2116646055
MESH:D020521 Stroke Vitamin E 3.4116517955
MESH:D013733 Testicular Diseases Toluene 4.8310048760 10514026
MESH:D013953 Thymus Neoplasms Benzene 4.8210850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.936587162 6582329 3712494 1399818 7505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.9316010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.018074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.0117653716
MESH:D014581 Urticaria Acetaminophen 2.8510982225
MESH:D014594 Uterine Neoplasms Benzene 4.2012562636
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0917334414 17638931 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
Pathway ID Pathway Name
KEGG:04360 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04660 T cell receptor signaling pathway
KEGG:04370 VEGF signaling pathway
KEGG:04310 Wnt signaling pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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