AutismKB 2.0

Annotation Detail for TCFL5


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Basic Information Top
Gene Symbol:TCFL5 ( CHA,E2BP-1,Figlb,MGC46135,bHLHe82 )
Gene Full Name: transcription factor-like 5 (basic helix-loop-helix)
Band: 20q13.33
Quick LinksEntrez ID:10732; OMIM: 604745; Uniprot ID:TCFL5_HUMAN; ENSEMBL ID: ENSG00000101190; HGNC ID: 11646
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TCFL5 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of TCFL5 mRNAdecreases expression 20106945
D015946 Ethylene Dibromide Ethylene Dibromide results in increased expression of TCFL5 mRNAincreases expression 15612046
D004642 Emodin Emodin results in increased expression of TCFL5 mRNAincreases expression 15612046
D005047 Etoposide TCFL5 protein affects the susceptibility to Etoposideaffects response to substance 16217747
C004312 glycidol glycidol results in increased expression of TCFL5 mRNAincreases expression 15612046
D019800 Phenol Phenol results in increased expression of TCFL5 mRNAincreases expression 17547211
D015125 Oxyquinoline Oxyquinoline results in increased expression of TCFL5 mRNAincreases expression 15612046
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.5414601052
MESH:D001859 Bone Neoplasms Phenol 5.4710556009
MESH:D001913 Bowen's Disease Phenol 6.1319293009
MESH:D001932 Brain Neoplasms glycidol 5.6512562636 10528639
MESH:D001943 Breast Neoplasms Ethylene Dibromide 2.5511921183
MESH:D001943 Breast Neoplasms Etoposide 2.5516322251
MESH:D001943 Breast Neoplasms glycidol 2.5511921183
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D056486 Drug-Induced Liver Injury Ethylene Dibromide 4.092862719
MESH:D005234 Fatty Liver Cyclosporine 3.1019224547
MESH:D005355 Fibrosis Cyclosporine 10.2012639820 12168785
MESH:D005355 Fibrosis Emodin 10.2019474275
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006561 Herpes Simplex Etoposide 4.9010809021
MESH:D006689 Hodgkin Disease Etoposide 4.0816200630 17606976 18180244 15147373 16135485
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D055623 Keratosis, Actinic Phenol 6.8219293009
MESH:D007674 Kidney Diseases Cyclosporine 7.128314463 10903974 18776723
MESH:D007674 Kidney Diseases Ethylene Dibromide 7.1212628311
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 5.2617077332
MESH:D008106 Liver Cirrhosis, Experimental Emodin 3.1015288473
MESH:D008114 Liver Neoplasms, Experimental glycidol 4.7712562636 12692647
MESH:D008175 Lung Neoplasms glycidol 3.7612692647 12562636
MESH:D008223 Lymphoma Etoposide 4.0912854902 12556972
MESH:D015674 Mammary Neoplasms, Animal glycidol 6.128818859 12692647 12562636
MESH:D008325 Mammary Neoplasms, Experimental Ethylene Dibromide 7.9611921183
MESH:D008325 Mammary Neoplasms, Experimental glycidol 7.9611921183
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms glycidol 5.5712562636
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009669 Nose Neoplasms Ethylene Dibromide 5.859385384
MESH:D010146 Pain Phenol 4.3817610455
MESH:D010190 Pancreatic Neoplasms Etoposide 3.3419003803
MESH:D010392 Pemphigus Phenol 6.8217163923 16522979
MESH:D010864 Pilonidal Sinus Phenol 6.8215622588 19655223
MESH:D011041 Poisoning Phenol 4.978825745
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Etoposide 3.9817172428
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012512 Sarcoma, Ewing's Etoposide 4.9914601052
MESH:D012878 Skin Neoplasms glycidol 6.8512562636 12692647
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.858532709
MESH:D013088 Spermatocele Phenol 6.0218646496
MESH:D013274 Stomach Neoplasms Ethylene Dibromide 3.923768853
MESH:D013274 Stomach Neoplasms glycidol 3.9211397402 8818859 12692647 12562636
MESH:D013964 Thyroid Neoplasms glycidol 5.1612562636
MESH:D014277 Trigeminal Neuralgia Phenol 6.8210223447 16527771
MESH:D014594 Uterine Neoplasms glycidol 5.9512562636 12692647
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014860 Warts Phenol 6.4719122958
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36398
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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